Obstetric and perinatal aspects of multiple pregnancy

Syusyuka, V.G.; Kyryliuk, A.D.; Babinchuk, О.V.; Boguslavska, N.Y.; Bachurina, O.I.; Yershova, O.A.

doi:10.30841/2708-8731.6.2021.244357

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…Враховуючи напруженість механізмів адаптації організму матері під час вагітності та наявність факторів, здатних негативно вплинути на перебіг вагітності (екстраґенітальні захворювання, стреси та ін. ), формуються ускладнення гестації та пологів, які супроводжуються дезадаптацією в системі "мати-плацента-плід" і, як наслідок, порушенням функціонального стану і розвитку плода [15,16,17].…”

Section: Study Of the Course Of Pregnancy In Women With Covid-19unclassified

Вивчення Перебігу Вагітності У Жінок При Covid -19

Школьник¹,

Malanchuk²,

Меленчук³

et al. 2023

Перспективи та інновації науки

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Section: Study Of the Course Of Pregnancy In Women With Covid-19unclassified

Вивчення Перебігу Вагітності У Жінок При Covid -19

Школьник¹,

Malanchuk²,

Меленчук³

et al. 2023

Перспективи та інновації науки

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“…Disorders of formation of the placenta, uterine-placental circulation can cause premature termination of pregnancy, placental dysfunction, fetal growth retardation, etc. [28]. As it is known, in prolonged pregnancy two main pathogenetic links of distress development are potentiated, namely, the maturity of fetal brain structures and morphofunctional involutionary changes in the placenta [17].…”

Section: н а д о п о м о г у л і к а р ю -п р а к т и к уmentioning

confidence: 99%

Obstetrical and perinatal consequences of birth in women depending on the term of gestation

Siusiuka,

Boguslavska,

Kyrylyuk

et al. 2023

RHW

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The objecticve: to analyze peculiarities of pregnancy course, childbirth and the condition of newborns in women, depending on the gestation period on the basis of clinical and statistical analysis.Materials and methods. An analysis of pregnancy course, childbirth and perinatal outcomes has been carried out in 137 pregnant women. Patients were divided into 2 groups depending on the gestational age: 41 patients (I group) delivered in 37–40 weeks of gestation and 96 patients (II group) – in 41-42 weeks of pregnancy. Functional assessment of the fetal condition was performed using a cardiotocographic examination with cardiomonitors «Oxford Team 8000» and Hewlett Packard according to the generally accepted method, ultrasound examination – by ultrasound machine «Biomedica Au-530» with a linear sensor of 3.5 MHz frequency. Variational and statistical processing of the results has been carried out using licensed standard packages of multivariate statistical analysis application programs «STATISTICA 13».Results. An evaluation of anamnestic data allowed to establish that the majority of patients in the II group (53.13 %) had extragenital pathology that was in 2 times more than in the I group (24.39 %). The frequency of chronic salpingo-oophoritis was also significantly higher in the II group compared to the I one (12.50 % and 2.44 %, respectively), and such pathology as uterine leiomyoma (7.29 %) and cervical dysplasia (4.17 %) were diagnosed only among the women in the II group.A higher rate of pregnancy loss, anemia during pregnancy and disorders of uteroplacental bloodflow in patients in the II group was determined. The frequency of obstetric complications in the II group was in 4 times higher compared to the I group. This had a direct impact on the increase in the rate of cesarean section and vacuum extraction of fetus. Thus, fetal distress during childbirth was diagnosed in 13.54 % of women in the II group and in 7.32 % in the I group, and the weakness of labor activity (8,3 %) and clinically contracted pelvis (5.21 %) were determined only in the II group. Trauma of the birth canal was found in 37.5 % of women in the II group, which was almost 4 times higher than in the group I (9.76 %). The frequency of postpartum bleeding was also higher in the group II (15.6 %) and exceeded the indicator in the I group (4.88 %) in 3 times.The signs of prolonged pregnancy were found in 7.32 % newborns in the I group and 13.54 % – in the II group. It should be noted that the clinical features of early adaptation, which are characterized by a low Apgar score at birth, as well as higher morbidity, including high frequency of damage to the nervous system were determined in the newborns in the II group.Conclusions. Results of the study indicate the importance of constitutional and age characteristics, as well as concomitant somatic pathology and genital inflammatory diseases in women with a delivery date of 41–42 weeks of pregnancy, which can increase the probability of postterm pregnancy in these women. According to the results of the comparative analysis in the research groups, depending on the date of delivery, the predominance of obstetric and perinatal complications was established in women who delivered at 41–42 weeks of pregnancy compared to women who had labor at 37–40 weeks. A high rate of obstetric complications (anomalies of uterine activity in labor, fetal distress, clinically contracted pelvis) had a direct impact on the increase in a percentage of operative delivery (vacuum extraction of a fetus and caesarean sections). Babies born at 41–42 weeks had clinical features of early adaptation, characterized by a low Apgar score, higher morbidity and frequent damage of the nervous system compared to newborns with gestation period of 37–40 weeks.

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Modern approaches to the diagnosis and treatment of polycystic ovary syndrome in adolescence

Serhiienko

Syusyuka

Makurina

et al. 2022

RHW

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Тhe diagnosis of polycystic ovary syndrome (PCOS) in adolescence still raises many questions. The problem is that the characteristics of normal puberty often coincide with the symptoms of PCOS. The article presents the criteria of a normal menstrual cycle, clinical and laboratory hyperandrogenism. In the diagnosis of the latter, the most informative indicators are the determination of the index of free testosterone and androstenedione, and the assessment of free and total testosterone are relatively low sensitivity. Clinical hyperandrogenism in adolescents includes only severe acne and hirsutism. The level of antimullerian hormone has no independent significance. Irregular menstrual cycles during the first year after menarche represent a normal period of puberty. At the second and third year after menarche , menstrual cycles of less than 21 days and more than 45 days are considered irregular, and from the fourth year – less than 21 days and more than 35 days. From the second year after menarche, menstrual irregularities are considered to be more than 90 days for any cycle. Primary amenorrhea is indicated by the absence of menarche at 15 years, or 3 years after telarche. Ultrasound is not used as a criterion for PCOS in the first 8 years after menarche due to the high frequency of ovarian multifollicularity in adolescence. Therefore, adolescent girls in the presence of menstrual disorders and hyperandrogenism may be diagnosed with «PCOS. Phenotype B» (ultrasound signs are not taken into account). Adolescents who have signs of PCOS but do not meet the diagnostic criteria are at risk for PCOS. The most important stage of PCOS therapy is lifestyle modification, normalization of body weight and metabolic processes. Combined oral contraceptives in adolescents are more often prescribed not for direct purposes (contraception), but as off-label therapy not only at diagnosis, but also in the «risk group», which involves the treatment of irregular menstrual cycles and / or clinical hyperandrogenism. In the absence of the effect of lifestyle changes, proper nutrition to correct metabolic disorders in addition to combined oral contraceptives may be prescribed metformin, inositol and etc.

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Obstetric and perinatal aspects of multiple pregnancy

Cited by 3 publications

References 78 publications

Вивчення Перебігу Вагітності У Жінок При Covid -19

Вивчення Перебігу Вагітності У Жінок При Covid -19

Obstetrical and perinatal consequences of birth in women depending on the term of gestation

Modern approaches to the diagnosis and treatment of polycystic ovary syndrome in adolescence

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