Obstetric and perinatal outcomes in pregnant women with COVID-19: an interim analysis

Khoiwal, Kavita; Agarwal, Arjit; Gaurav, Amrita; Kumari, Ranjeeta; Mittal, Anmol; Sabnani, Smrati; Mundhra, Rajlaxmi; Chawla, Latika; Bahadur, Anupama; Chaturvedi, Jaya

doi:10.1080/03630242.2021.2007199

Cited by 12 publications

(16 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This retrospective study emphasizes the severity of COVID-19 caused by the Delta variant of SARS-CoV2 in pregnancy, particularly in non-vaccinated populations. We experienced high rates of severe maternal outcomes and maternal mortality [8,9].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Severity Among Non-Vaccinated Pregnant Women During the Delta Wave in Tunisia: A Retrospective Monocentric Study

Kammoun¹,

Jarraya²,

Mejdoub³

2022

J Inter Med Res & Rep

View full text Add to dashboard Cite

Introduction: Pregnant women are vulnerable to SARS-CoV2 infection, particularly with the Delta variant. The aim of our study is to describe the COVID-19 syndrome among non-vaccinated pregnant women during the delta wave and to investigate risk factors for severe forms. Methods: In this study, we included all non-vaccinated pregnant women who tested positive for COVID-19 and who required hospital admission at any stage of gestation during the Delta wave in the maternity of Sfax, Tunisia. Patients were divided into 2 groups according to the mode of delivery in case of completed pregnancies and according to the severity of the disease. Severe COVID-19 is considered when the pregnant woman requires advanced oxygen support or intensive care unit referral. We performed univariate and multivariate logistic regression models to investigate the predictors of severe maternal outcomes among infected pregnant women. The significance level was set top ≤ 0.05. Results: one hundred patients were included. Severe adverse outcomes were observed in 23 patients (group1). The mortality rate during the Delta wave was 6%. The mode of delivery had not influenced the maternal and perinatal outcomes. Age >35 years old [OR 3.16, 95% CI 1.13- 8.84], BMI>30 kg/m2 [OR 2.63, 95% CI 1.0 -6.95], preeclampsia [OR 4.0, CI 95% 1.04- 15.32], dyspnea [OR 7.55, 95% CI 2.62- 21.7], cytolysis [ OR 4.6, 95% CI 1.48- 14.2], and lung injury in CT Scan > 50% [OR9.6, 95%CI 1.48-62.1] were significantly associated with an increased risk of severe maternal outcomes. Conclusions: During the delta wave in Tunisia, non-vaccinated pregnant women seem to be at higher risk of severe maternal outcomes and maternal deaths. The main risk factors for severe outcomes were age 35, obesity, preeclampsia, cytolysis, and severe lung damage in the CT scan.

show abstract

Section: Discussionmentioning

confidence: 99%

COVID-19 Severity Among Non-Vaccinated Pregnant Women During the Delta Wave in Tunisia: A Retrospective Monocentric Study

Kammoun¹,

Jarraya²,

Mejdoub³

2022

J Inter Med Res & Rep

View full text Add to dashboard Cite

show abstract

“…The main outcome of our study is that it allowed us to show the benefits of vaccination even during pregnancy. Even if the majority of pregnant women tested positive recovered within one week, the incidence of complications remains high and may lead to maternal morbidity and mortality [19,20] and poor fetal outcomes in form of early pregnancy loss, prematurity, oligohydramnios, intrapartum fetal distress, and sometimes fetal demise [21]. To improve maternal and fetal outcomes, COVID-19 vaccination in pregnancy has been endorsed by multiple professional societies, including the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine and the World Health Organization.…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Impact of COVID-19 vaccination among pregnant women requiring hospital admission: prospective observational research

Jarraya¹,

Kammoun²,

Amouri³

et al. 2023

It Journ Gyn Obs

View full text Add to dashboard Cite

The aim of this study was to assess the impact and effectiveness of vaccination among the pregnant population on maternal, obstetrical, and fetal outcomes. Material and Methods:In this study we included all parturients tested positive for COVID 19 during pregnancy and who needed hospitalization at any stage of gestation. Then, patients were divided into 2 groups according to their vaccination status: M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o nThe Vaccinated Group: included pregnant women with completed vaccination by receiving 3 doses of mRNA Vaccine or 2 doses on condition that the second dose received within the last 6 months.The non-vaccinated group: included pregnant women who had no vaccination against COVID 19.We collected data about obstetrical and fetal outcomes with 3 months of follow-up.Results: 145 parturients were admitted for COVID 19 in the maternity of Sfax in Tunisia. The vaccinated group included 45 patients and the non-vaccinated group included 100 patients. Demographic parameters were comparable in both groups. The vaccination reduced the rate of hospitalization in Intensive care units from 23% to 4.3%; p<0.001. Cesarean section delivery was seen in 56 cases from 76 patients who delivered while infected (73%) versus 11 cases from 33 who delivered in the vaccinated group (33.3%) with p<0.001. The vaccination reduced the risk of prematurity from 35% to 6.6% with p<0.001. No cases of vertical transmission were noted in either group. Conclusions:Pregnant women seem to be protected from severe forms and severe complications of COVID 19. Obstetrical and neonatal outcomes appear to be improved with vaccination.

show abstract

“…At the beginning of this pandemic, there were few data regarding the virus effects on pregnancy and thus the increased Life 2022, 12, 6 2 of 10 fear in starting any infertility treatment. Over the course of 2020 and 2021, more data on pregnant women with and without the infection became available [5,6]. It seems that the COVID-19 pandemic did not compromise ART early pregnancy outcomes in comparison to a pre-COVID time frame [6], even though obstetric and perinatal complications were higher in COVID-positive pregnant women, in particular if they were symptomatic [5].…”

Section: Introductionmentioning

confidence: 99%

“…Over the course of 2020 and 2021, more data on pregnant women with and without the infection became available [5,6]. It seems that the COVID-19 pandemic did not compromise ART early pregnancy outcomes in comparison to a pre-COVID time frame [6], even though obstetric and perinatal complications were higher in COVID-positive pregnant women, in particular if they were symptomatic [5]. However, apart from a physical threat, this pandemic has also exerted a great impact on the population's psychological health.…”

Section: Introductionmentioning

confidence: 99%

Impact of COVID-19 on Infertility Treatments: Not Even a Global Pandemic Was Strong Enough to Hamper Successful Pregnancies

Rodríguez-Varela

Mariani²,

Dolz

et al. 2021

Life

View full text Add to dashboard Cite

The COVID-19 global pandemic has meant a sanitary and social threat at every level and it was not any different for the assisted reproduction industry. This retrospective two-arm study aims to describe its impact on infertility treatments performed in our clinics (IVI Spain, Rome, and Lisbon) regarding: (1) assessment of COVID-19 impact in the amount, type, and success of infertility treatments performed during 2020 compared to 2019; and (2) description of the psychological status of women who got pregnant during the first months of the pandemic and its correlation with their final pregnancy outcome. On the one hand, this pandemic has led to a significant reduction in the total number of treatments performed, even though the proportion of the different types was almost unaltered. Additionally, its impact on pregnancy rates was not clinically relevant. On the other hand, the psychological status of pregnant women did not seem to affect their final pregnancy outcome. These results suggest that, even in the event of a negatively affected psychological status in our study population, it was not translated into an impaired pregnancy outcome. Hence, the COVID-19 global pandemic, although devastating, might not have exerted a clinically relevant negative impact on the overall pregnancy outcome in our clinics.

show abstract

Obstetric and perinatal outcomes in pregnant women with COVID-19: an interim analysis

Cited by 12 publications

References 18 publications

COVID-19 Severity Among Non-Vaccinated Pregnant Women During the Delta Wave in Tunisia: A Retrospective Monocentric Study

COVID-19 Severity Among Non-Vaccinated Pregnant Women During the Delta Wave in Tunisia: A Retrospective Monocentric Study

Impact of COVID-19 vaccination among pregnant women requiring hospital admission: prospective observational research

Impact of COVID-19 on Infertility Treatments: Not Even a Global Pandemic Was Strong Enough to Hamper Successful Pregnancies

Contact Info

Product

Resources

About