Obstetric Haemorrhage

MacLean, A. B.

doi:10.3109/01443615.2012.638554

Journal of Obstetrics and Gynaecology

2011

DOI: 10.3109/01443615.2012.638554

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Obstetric Haemorrhage

A. B. MacLean¹

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Modeling thrombin generation: plasma composition based approach

Brummel‐Ziedins

Everse

Mann

et al. 2013

J Thromb Thrombolysis

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Thrombin has multiple functions in blood coagulation and its regulation is central to maintaining the balance between hemorrhage and thrombosis. Empirical and computational methods that capture thrombin generation can provide advancements to current clinical screening of the hemostatic balance at the level of the individual. In any individual, procoagulant and anticoagulant factor levels together act to generate a unique coagulation phenotype (net balance) that is reflective of the sum of its developmental, environmental, genetic, nutritional and pharmacological influences. Defining such thrombin phenotypes may provide a means to track disease progression pre-crisis. In this review we briefly describe thrombin function, methods for assessing thrombin dynamics as a phenotypic marker, computationally derived thrombin phenotypes versus determined clinical phenotypes, the boundaries of normal range thrombin generation using plasma composition based approaches and the feasibility of these approaches for predicting risk.

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Modeling thrombin generation: plasma composition based approach

Brummel‐Ziedins

Everse

Mann

et al. 2013

J Thromb Thrombolysis

View full text Add to dashboard Cite

show abstract

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Obstetric Haemorrhage

Cited by 1 publication

References 9 publications

Modeling thrombin generation: plasma composition based approach

Modeling thrombin generation: plasma composition based approach

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