Obstetric outcome of in vitro fertilization pregnancies compared with normally conceived pregnancies

Tan, Seang‐Lin; Doyle, Patricia; Campbell, Stuart; Beral, Valerie; Rizk, Botros; Brinsden, Peter; Mason, Bridgett; Edwards, Robert G.

doi:10.1016/s0002-9378(11)91589-0

Cited by 237 publications

(112 citation statements)

References 11 publications

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“…The incidence of major congenital malformations in both has been reported to be similar to that in population based estimates 911 12 Data from the register of IVF and GIFT pregnancies in Australia and New Zealand suggest, however, a higher incidence of transposition of the great vessels and spina bifida in newborn infants conceived by IVF than in the general population 13. Moreover, a survey of all children born after assisted conception, including IVF, has shown an increased incidence of congenital malformations 14…”

mentioning

confidence: 58%

“…A possible disadvantage of doing this would be a lowering of pregnancy rate in couples who are not typical of all parents as they tend to be older than average and their infertility may have resulted from medical or genetic disorders 12. Recent research into conditions which influence pregnancy rate including embryo “quality” and maternal age has shown that it is possible to transfer two embryos without lowering the chances of a successful pregnancy after IVF treatment 38.…”

Section: Discussionmentioning

confidence: 99%

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Children conceived by in vitro fertilisation after fresh embryo transfer

D'Souza

Rivlin

Cadman

et al. 1997

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Aims-To compare the outcome in in vitro fertilisation (IVF) children (after fresh embryo transfer) from multiple and singleton births with one another, and with normally conceived control children. Methods-A cohort of 278 children (150 singletons, 100 twins, 24 triplets and four quadruplets), conceived by IVF after three fresh embryos had been transferred, born between October 1984 and December 1991, and 278 normally conceived control children (all singletons), were followed up for four years after birth. They were assessed for neonatal conditions, minor congenital anomalies, major congenital malformations, cerebral palsy and other disabilities. Control children, all born at term, were matched for age, sex and social class. Results-The ratio of male:female births was 1.03. Forty six per cent of IVF children were from multiple births; 34.9% were from preterm deliveries; and 43.2% weighed less than 2500 g at birth. The IVF singletons were on average born one week earlier than the controls, weighed 400 g less, and had a threefold greater chance of being born by caesarean section. The higher percentage of preterm deliveries was largely due to multiple births and they contributed to neonatal conditions in 45.0% of all IVF children. The types of congenital abnormalities varied: 3.6% of IVF children and 2.5% of controls had minor congenital anomalies, and 2.5% of IVF children and none of the controls had major congenital malformations. The numbers of each specific type of congenital abnormality were small and were not significantly related to multiple births. IVF children (2.1%) and 0.4% of the controls had mild/moderate disabilities. They were all from multiple births, including two children with cerebral palsy who were triplets. Conclusions-The outcome of IVF treatment leading to multiple births is less satisfactory than that in singletons because of neonatal conditions associated with preterm delivery and disabilities in later childhood. A reduction of multiple pregnancies by limiting the transfer of embryos to two instead of three remains a high priority. (Arch Dis Child 1997;76:F70-F74)

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mentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Children conceived by in vitro fertilisation after fresh embryo transfer

D'Souza

Rivlin

Cadman

et al. 1997

Archives of Disease in Childhood - Fetal and Neonatal Edition

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“…Although it may seem that the only difference between IVF and natural conception is the conception itself, there are a number of reasons why having a child by IVF may result in a rather different experience for parents. One very important difference is the higher incidence of multiple births, preterm births and low birth weight infants following IVF (e.g., Beral, Doyle, Tan, Mason, & Campbell, 1990;Olivennes et al, 2002;Rufat, Olivennes, de Mouzon, Dehan, & Frydman, 1994;SART Registry, 1999;Tan et al, 1992;Tanbo, Dale, Lunde, Moe, & Abyholm, 1995;Vayena & Rowe, 2002;Wang et al, 1994;Westergard, Johansen, Erb, & Andersen, 1999). Whereas only 1% of natural births involve twins, triplets or more, this is true of more than one-quarter of births resulting from IVF.…”

Section: Ivf Familiesmentioning

confidence: 99%

Practitioner Review: Outcomes for parents and children following non‐traditional conception: what do clinicians need to know?

Golombok¹,

MacCallum²

2003

Child Psychology Psychiatry

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Few studies have included children at adolescence or beyond, and little is known about the consequences of conception by assisted reproduction from the perspective of the individuals concerned. In addition, there are some types of assisted reproduction family, such as families created through a surrogacy arrangement or through embryo donation, about whom little is known at all. Although existing knowledge about the impact of assisted reproduction for parenting and child development does not give undue cause for concern, there remain a number of unanswered questions in relation to children born in this way.

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“…Risk of complications after IVF and OI are many folds higher than in normal conception. [1][2][3][4][5] Since the Saudi population characteristics are changing and there is a high percentage of younger population, pregnancies due to IVF and OI are bound to increase in near future. It is paramount that an assessment is made on the obstetric and neonatal outcomes of pregnancies due to such procedures.…”

Section: Introductionmentioning

confidence: 99%