Obstetric Outcomes and Congenital Abnormalities After In Vitro Maturation, In Vitro Fertilization, and Intracytoplasmic Sperm Injection

Abstract

All ART pregnancies are associated with an increased risk of multiple pregnancy, cesarean delivery, and congenital abnormality. Compared with IVF and ICSI, IVM is not associated with any additional risk.

Complications in pregnancies after in vitro fertilization and embryo transfer

“…It has been shown that ART babies have increased neonatal morbidity. 15 Many other studies have suggested an increase in neonatal morbidity and mortality but do not sufficiently address the effect of confounders such as birth weight and gestational age. …”

Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment

“…Some studies have also found a greater risk of birth defects among singletons and multiples conceived using ART compared with those conceived without treatment (15)(16)(17)(18); however, the evidence is inconsistent and suggests that risk may be related to underlying infertility (19)(20)(21). Concern about long-term sequelae of ART use, such as neurodevelopmental problems, has been identified as an area needing further research (22)(23)(24)(25).…”

Oncofertility in Canada: cryopreservation and alternative options for future parenthood

“…The 4 live births after ivm and oocyte vitrification demonstrated no congenital anomalies or perinatal morbidity 46 . In pco patients, ivm outcomes have also been studied sparingly, but offspring have thus far shown no increased rates of congenital anomalies 50 or early developmental abnormalities at 2 years of age 51,52 . Buckett et al 50 studied 344 art pregnancies, of which 55 were achieved through ivm.…”

“…In pco patients, ivm outcomes have also been studied sparingly, but offspring have thus far shown no increased rates of congenital anomalies 50 or early developmental abnormalities at 2 years of age 51,52 . Buckett et al 50 studied 344 art pregnancies, of which 55 were achieved through ivm. No significant differences in major or minor abnormalities were noted between ivm infants and spontaneously conceived controls (or: 1.21; 95% confidence interval: 0.63 to 2.32) 50 .…”

“…Buckett et al 50 studied 344 art pregnancies, of which 55 were achieved through ivm. No significant differences in major or minor abnormalities were noted between ivm infants and spontaneously conceived controls (or: 1.21; 95% confidence interval: 0.63 to 2.32) 50 .…”