Kyphoscoliosis is a spine deformity with posterior convex angulations greater than 40 degrees of a segment of vertebral column, combined with lateral and rotational deformities. Pregnancy of a patient with kyphoscoliosis is a very dangerous phenomenon. The majority of patients with spinal cord injuries involved like in this case are highly likely to have complications during pregnancy. The patient in this case suffered a spinal cord injury and kyphoscoliosis 20 years ago due to slip down. There has not been any report that a pregnant woman accompanied with kyphoscoliosis, spinal cord injury and placenta previa low-lying gave birth to a baby after 37 gestational weeks. The patient was transferred to our hospital due to cerebral hemorrhage during the confinement period, however, she gained a complete recovery under treatment and thus left our hospital. There is no exact guideline to keep pregnancy when high risk patients desire to maintain pregnancy. We report the case of a woman giving birth with kyphoscoliosis, spinal cord injury and placenta previa low-lying with a brief review of literature.