Obstetrical complications of thin endometrium in assisted reproductive technologies: a systematic review

Mouhayar, Youssef; Franasiak, Jason M.; Sharara, Fady I.

doi:10.1007/s10815-019-01407-y

Cited by 67 publications

(34 citation statements)

References 21 publications

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“…uteroplacental circulation that adversely affect the growing fetus (26). While our results did not demonstrate an association between endometrial thickness and prevalence of preterm and small-for-gestational-age neonates, those of other studies have shown such association (32,33). Similarly, our results did not show an association between endometrial thickness and obstetric complication rate, while prior studies have shown significant correlations between endometrial thickness and a variety of individual obstetric complications.…”

Section: Endometrial Thickness and Birthweightcontrasting

confidence: 86%

The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer

2021

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Objective: To determine the impact of endometrial thickness on live birth outcomes and obstetric complication rate after hormonereplaced frozen embryo transfer. Design: Retrospective cohort study. Setting: Large, urban, academic fertility center. Patient(s): All patients with a singleton live birth after single euploid embryo transfer (by array comparative genomic hybridization or next-generation sequencing) in a hormone-replaced frozen embryo transfer cycle between January 2017 and December 2018 were reviewed. Intervention(s): None. Main Outcome measure(s): The primary outcomes were birth weight and obstetric complication rate. Result(s): A total of 492 patients were included. The median endometrial thickness was 8.60 mm (range, 6.0-20.0). The median gestational age at live birth was 39.4 weeks with a median birth weight of 3,345.2 g. Endometrial thickness was significantly correlated with birth weight. When patients were dichotomized into groups (those with an endometrial thickness of <7 mm and those with an endometrial thickness of >7 mm), neonates born from endometria with a thickness of <7 mm were born earlier (37.3 vs. 39.4 weeks and born with lower birth weights (2,749.9 vs. 3,345.2 g). It should be noted that only seven patients had an endometrium measuring <7 mm. Moreover, 7.1% (n ¼ 35) of patients had an obstetric complication. Endometrial thickness was not significantly associated with obstetric complications, even with adjustments for age and medical history. Conclusion(s): Endometrial thickness may be a valuable predictor of placental health and birth weight. Further study is required to examine the relationship with individual obstetric complications, as our study may not have been powered to observe differences in obstetric complication rate, as well as the relationship between endometrial thickness and outcomes in natural frozen embryo transfer cycles.

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Section: Endometrial Thickness and Birthweightcontrasting

confidence: 86%

The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer

2021

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“…Despite the vast diversity of treatment, most of these treatment options result in a minor change in the endometrium thickness and pregnancy rate [ 22 ]. Currently, there is no one acceptable approach to treat thin endometrium [ 23 ], thus the need for an alternative and complementary therapy for patients with thin endometrium.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of electroacupuncture for thin endometrium in infertile women: study protocol for a single-blind, randomized controlled trial

Wang

et al. 2021

Trials

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Background Thin endometrium negatively impacts the reproductive function. Current treatments for thin endometrium do not always improve endometrial receptivity. Preliminary evidence suggests that electroacupuncture could have potential therapy for thin endometrium in infertile women. Thus, this randomized controlled trial was designed to test whether electroacupuncture can improve endometrial receptivity in infertile women with thin endometrium. Methods This study is a randomized, single-blinded, controlled, clinical trial. A total of 142 eligible patients will be recruited and randomly assigned to the electroacupuncture (EA) group or the sham electroacupuncture (SEA) group in a 1:1 ratio. Participants will receive 36 sessions over three menstrual cycles (12 weeks in total), with the same acupoint prescription. The primary outcome of this trial is endometrial thickness in the midluteal phase. The secondary outcomes include endometrial pattern, resistance index (RI) and pulsatility index (PI) of bilateral uterine artery and endometrium blood flow, serum estradiol (E2) and progesterone (P), and pregnancy rate. The pregnancy rate will be evaluated during a 6-month follow-up after completion of the trial. All other outcomes will be evaluated before treatment, during the treatment of 1st, 2nd, and 3rd menstrual cycle, and 6 months after treatment. Discussion If the outcome confirms the effectiveness of electroacupuncture for thin endometrium in infertile women, this treatment will be proposed for application in clinical practice. Trial registration Chinese Clinical Trials Registry ChiCTR2000029983. Registered on 18 February 2020

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“…However, an increasing number of studies have shown that the process of ART, including exposure to superphysiological doses of hormones and embryo manipulation in the laboratory, may have an adverse effect on the perinatal outcome [7][8][9][10] . Furthermore, defective placentation, particularly in patients with thin endometrium thickness (EMT), may be an important cause of these poor perinatal outcomes 11,12 . However, there is no exact definition of "thin EMT", and most studies have reported cutoff values of 7 mm, 7.5 mm or 8 mm [13][14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

Thin endometrial thickness is a risk factor for singleton low birth weight from single blastocyst transfer: A retrospective cohort study

Du¹,

Zhang²,

Liu³

et al. 2021

Preprint

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Objective To explore whether thin endometrial thickness (EMT) is associated with singleton low birth weight (LBW) from single fresh blastocyst transfer. Design Retrospective cohort study. Setting Reproductive center. Population All women were ≤40 years old and underwent single fresh blastocyst transfer and singleton live birth. Interventions None. Methods Multivariable logistic regression was used to evaluate the association between thin EMT and singleton LBW. Main outcome measures LBW was the primary concern of this study. Results In total, 2847 women met the study inclusion criteria. The neonatal birthweight in the EMT ≤7.5 mm group was significantly lower than that in the EMT 7.6~12.0 mm and EMT >12.0 mm group (P<0.001). The rate of LBW in the EMT ≤7.5 mm group was 24.9%, which was significantly higher than the 4.0% in the EMT 7.6~12.0 mm group and the 5.3% in the EMT >12.0 mm group (P<0.001). The total neonatal malformation rate was similar between the groups (1.1%, 0.8% and 1.5%, P=0.21). After multiple logistic regression analysis, EMT≤7.5 mm was an independent risk factor for LBW (adjusted odds ratio [AOR]: 4.39, 95% CI: 1.85～10.46, P<0.001). Conclusions Thin EMT (≤7.5 mm) on the hCG trigger day is an independent risk factor for singleton LBW from single fresh blastocyst transfer. The neonatal birthweight in the EMT ≤7.5 mm group was significantly lower than that in the EMT 7.6~12.0 mm and EMT >12.0 mm groups. The total neonatal malformation rate was comparable between the groups.

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Obstetrical complications of thin endometrium in assisted reproductive technologies: a systematic review

Cited by 67 publications

References 21 publications

The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer

The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer

Effectiveness of electroacupuncture for thin endometrium in infertile women: study protocol for a single-blind, randomized controlled trial

Thin endometrial thickness is a risk factor for singleton low birth weight from single blastocyst transfer: A retrospective cohort study

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