Understanding the Problem The United States is in the midst of a fatal drug crisis among pregnant and postpartum women-over the past 2 decades, the rates of opioid use disorder (OUD) have quadrupled. 1 Among reproductive-age women, drug-related death-death from poisoning caused by legal, illegal, or medically prescribed drugs-has emerged as a leading cause of death; however, less is understood about the circumstances and preventability of these deaths in pregnant and postpartum women. 2 Maternal mortality review committees (MMRCs) are 1 of 3 national surveillance mechanisms for maternal death in the United States. 3 Because the National Vital Statistics System and the Pregnancy Mortality Surveillance System rely primarily on birth and death certificates to capture maternal deaths, MMRCs are uniquely positioned to analyze the root causes of maternal drug-related deaths. As of February 2020, there were 48 MMRCs nationwide (46 states and 2 cities) that provide multidisciplinary reviews of pregnancy-associated and pregnancy-related deaths (Table 1) including identification of contributing factors and recommended solution at the patient, provider, community, facility, and system levels. Multiple MMRCs have recently reported that mental health conditions now account for a significant proportion of pregnancy-associated and pregnancy-related deaths. 1,3,6e8 Although most drug-related deaths have been