2023
DOI: 10.1161/jaha.123.032028
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Obstructive Hypertrophic Cardiomyopathy and Takotsubo Syndrome: How to Deal With Left Ventricular Ballooning?

Rodolfo Citro,
Michele Bellino,
Elisa Merli
et al.

Abstract: Currently, there are 2 proposed causes of acute left ventricular ballooning. The first is the most cited hypothesis that ballooning is caused by direct catecholamine toxicity on cardiomyocytes or by microvascular ischemia. We refer to this pathogenesis as Takotsubo syndrome. More recently, a second cause has emerged: that in some patients with underlying hypertrophic cardiomyopathy, left ventricular ballooning is caused by the sudden onset of latent left ventricular outflow tract obstruction. When it becomes s… Show more

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Cited by 9 publications
(1 citation statement)
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“…More recently, another possibility has emerged: in individuals with underling hypertrophic cardiomyopathy, left ventricular ballooning might be triggered by a sudden onset of latent left ventricular outflow tract obstruction. When it becomes severe and unrelenting, severe afterload mismatch and acute supply demand ischemia result in ballooning 30 . The clinical features of patients with ballooning due to these two distinct causes can overlap, potentially leading to underdiagnosis and misclassification.…”
Section: Discussionmentioning
confidence: 99%
“…More recently, another possibility has emerged: in individuals with underling hypertrophic cardiomyopathy, left ventricular ballooning might be triggered by a sudden onset of latent left ventricular outflow tract obstruction. When it becomes severe and unrelenting, severe afterload mismatch and acute supply demand ischemia result in ballooning 30 . The clinical features of patients with ballooning due to these two distinct causes can overlap, potentially leading to underdiagnosis and misclassification.…”
Section: Discussionmentioning
confidence: 99%