Obstructive Jaundice as the Initial Manifestation of Gastric Adenocarcinoma

Ansari, Shehbaz M; Patel, D.; Aswani, Yashant; Bairy, Abhishek; Narvel, Hiba

doi:10.7759/cureus.32478

Cited by 1 publication

(1 citation statement)

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“…11,12 At all stages of this process, there are several environmental and biological factors that influence progression of the gastric lesions. 13 Diagnosis of these mucosal lesions requires histological examination of invasively obtained gastric biopsies. Despite histological diagnosis being regarded as the gold standard, the approach is limited by the patchy nature of these lesions.…”

Section: Introductionmentioning

confidence: 99%

Nationwide survey ofHelicobacter pyloriseropositivity and gastric atrophy in Zambia

Kayamba,

Munshi,

Hankolwe

et al. 2024

Helicobacter

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BackgroundHelicobacter pylori (H. pylori) is a common bacterial infection which predominately drives upper gastrointestinal pathology. We carried out a nationwide serological survey in response to the deficiency of robust African data on H. pylori prevalence, age of acquisition, socio‐geographic determinants, and impact on gastric physiology.Materials and MethodsThis was a cross‐sectional study of archival plasma samples collected during the Zambia Population‐based HIV impact Assessment (ZAMPHIA) 2016 survey. ZAMPHIA used a two‐stage door‐to‐door stratified cluster sample approach to collect samples from adults and children from age 0 to 59 years (n = 24,266). We randomly retrieved one fifth of these samples from each of Zambia's 10 provinces and used ELISA to test for H. pylori IgG antibodies, pepsinogen 1 and 2 and gastrin‐17. A pepsinogen 1:2 ratio of <3 was used to define gastric atrophy.ResultsThe analysis of 4050 plasma samples (30% <16 years, 53% females) revealed an overall H. pylori seroprevalence of 79%. By the age of 10 years, more than 75% of the children had H. pylori. Urban residence was associated with increased odds (OR 1.8, 95% CI 1.5–2.2, p < 0.001) and HIV infection was associated with reduced odds (OR 0.7, 95% CI 0.5–0.9, p = 0.02) of H. pylori seropositivity. Gastric atrophy was detected in 6% of H. pylori seropositive adults below 45 years of age and 9% in those between 45 and 59 years.ConclusionsWe have confirmed a high prevalence of H. pylori seropositivity in Zambia, predominantly in urban settings. The prevalence of gastric atrophy is broadly consistent with other populations around the globe, but our sample did not include adults over 60 years.

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Section: Introductionmentioning

confidence: 99%