Obstructive pulmonary disease in old age among individuals born preterm

Broström, Eva Berggren; Akre, Olof; Katz‐Salamon, Miriam; Jaraj, David; Kaijser, Magnus

doi:10.1007/s10654-013-9761-7

Cited by 62 publications

(60 citation statements)

References 21 publications

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“…Lower birth weights in infants born preterm may be a factor; in a population-based case-control study an increased risk of hospitalisation for respiratory disease in adults with low birth weight compared to those with normal birth weight was reported [27]. In a recently reported population-based cohort study, low birth weight and preterm birth were identified as risk factors for the presence of obstructive airway disease in old age [28].…”

Section: Discussionmentioning

confidence: 97%

Impaired lung function and health status in adult survivors of bronchopulmonary dysplasia

et al. 2013

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More infants with bronchopulmonary dysplasia (BPD) now survive to adulthood, but little is known regarding persisting respiratory impairment. We report respiratory symptoms, lung function and health-related quality of life (HRQoL) in adult BPD survivors compared with preterm (non-BPD) and fullterm controls.Respiratory symptoms (European Community Respiratory Health Survey) and HRQoL (EuroQol (EQ)-5D) were measured in 72 adult BPD survivors (mean¡SD study age 24.1¡4.0 years; mean¡SD gestational age 27.1¡2.1 weeks; and mean¡SD birth weight 955¡256 g) cared for in the regional neonatal intensive care unit, Royal Maternity Hospital, Belfast, UK (between 1978 and 1993). These were compared with 57 non-BPD controls (mean¡SD study age 25.3¡4.0 years; mean¡SD gestational age 31.0¡2.5 weeks; and mean¡SD birth weight 1238¡222 g) and 78 full-term controls (mean¡SD study age 25.7¡3.8 years; mean¡SD gestational age 39.7¡1.4 weeks; and mean¡SD birth weight 3514¡456 g) cared for at the same hospital. Spirometry was performed on 56 BPD, 40 non-BPD and 55 full-term participants.BPD subjects were twice as likely to report wheeze and three times more likely to use asthma medication than controls. BPD adults had significantly lower forced expiratory volume in 1 s and forced expiratory flow at 25-75% of forced vital capacity than both the preterm non-BPD and full-term controls (all p,0.01). Mean EQ-5D was 6 points lower in BPD adults compared to full-term controls (p,0.05).BPD survivors have significant respiratory and quality of life impairment persisting into adulthood.@ERSpublications Adult BPD survivors are more likely to have more respiratory symptoms, impaired health status and airflow obstruction than controls

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Section: Discussionmentioning

confidence: 97%

Impaired lung function and health status in adult survivors of bronchopulmonary dysplasia

et al. 2013

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“…Children with a history of prematurity have been shown to be at increased risk for obstructive lung disease 21 and cognitive deficits 22 , among other medical conditions. 23 This population has also been shown to be at risk for disorders affecting sleep, including increased rates of OSAS 3, 24 and differences in circadian rhythm.…”

Section: Discussionmentioning

confidence: 99%

Periodic limb movements and restless legs syndrome in children with a history of prematurity

et al. 2017

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Introduction Little is known about which children are at increased risk for restless legs syndrome (RLS) and periodic limb movement disorder (PLMD). Polysomnographic data from the Caffeine for Apnea of Prematurity-Sleep (CAPS) study showed a high prevalence of elevated periodic limb movement index in a cohort of ex-preterm children, but the clinical importance of this finding, such as association with RLS, is unknown. We hypothesized that ex-preterm children would have a high prevalence of RLS and PLMD. Methods Ex-preterm children enrolled in CAPS, now aged 5-12 years, completed home polysomnography and standardized questionnaires. A diagnosis of RLS or PLMD was established by participants meeting the International Classification of Sleep Disorders, 3rd edition criteria based on questionnaires and polysomnograms. Clinically available serum ferritin levels were assessed. Results 167 participants underwent polysomnography and completed all questionnaires. The overall prevalence of RLS was 14/167 (8.4%). An additional 13 subjects (7.8%) were found to have PLMD. Of the 26 participants who had >5 periodic limb movements/hour, 7 (26.9%) had RLS and 13 (50%) had PLMD. Serum ferritin levels were <50 mcg/L (range 11 to 38.4) for all 8 participants referred for testing. Conclusions Children with a history of prematurity have a high prevalence of RLS, particularly those with elevated periodic limb movements. Iron deficiency likely contributes to RLS and PLMD symptoms in this population. Clinicians evaluating ex-preterm children with sleep disturbances should evaluate for RLS and PLMD. Further studies including serum ferritin evaluation are needed to confirm these findings.

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“…The long-term clinical relevance of small to moderate lung function deficits in childhood related to preterm birth and perinatal events is not known. However, concern has been raised as to whether individuals born preterm, especially those born extremely preterm, may be at risk of developing COPD-like phenotypes later in life 30 . In addition, it is still unclear whether preterm birth is associated with a more rapid age-related decline in lung function in adulthood.…”

Section: Factors Affecting Lung Function Growthmentioning

confidence: 99%

Recent advances in understanding lung function development

Melén

Guerra

2017

F1000Res

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Recent years have witnessed critical contributions to our understanding of the determinants and long-term implications of lung function development. In this article, we review studies that have contributed to advances in understanding lung function development and its critical importance for lung health into adult life. In particular, we have focused on early life determinants that include genetic factors, perinatal events, environmental exposures, lifestyle, infancy lower respiratory tract infections, and persistent asthma phenotypes. Longitudinal studies have conclusively demonstrated that lung function deficits that are established by school age may track into adult life and increase the risk of adult lung obstructive diseases, such as chronic obstructive pulmonary disease. Furthermore, these contributions have provided initial evidence in support of a direct influence by early life events on an accelerated decline of lung function and an increased susceptibility to its environmental determinants well into adult life. As such, we argue that future health-care programs based on precision medicine approaches that integrate deep phenotyping with tailored medication and advice to patients should also foster optimal lung function growth to be fully effective.

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Obstructive pulmonary disease in old age among individuals born preterm

Cited by 62 publications

References 21 publications

Impaired lung function and health status in adult survivors of bronchopulmonary dysplasia

Impaired lung function and health status in adult survivors of bronchopulmonary dysplasia

Periodic limb movements and restless legs syndrome in children with a history of prematurity

Recent advances in understanding lung function development

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