Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction

Su, Jia-Zeng; Yang, Ning; Liu, Xiaojing; Cai, Zhi‐Gang; Lv, Lei; Zhang, Lei; Wu, Li‐Ling; Liu, Deng-gao; Ren, Wen-Ge; Gao, Yan; Yu, Guang‐Yan

doi:10.1136/bjophthalmol-2014-305117

Cited by 13 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our series, duct obstruction occurred in 16 transplanted glands, and five glands finally failed to achieve duct patency after duct reconstruction with venous graft or recontouring of the duct orifice. Follow-up results of our study showed that viscous secretions resulted from chronic obstructive sialadenitis of transplanted SMGs, which was a primary cause of patient dissatisfaction 23 . Therefore, duct obstruction owing to low secretion of transplanted SMGs is another main factor influencing outcomes of this technique, and thus, promoting gland secretion during the 'latent period' to prevent duct obstruction is critical.…”

Section: Discussionmentioning

confidence: 64%

Factors influencing the long-term results of autologous microvascular submandibular gland transplantation for severe dry eye disease

Zhang

Cai

et al. 2019

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 64%

Factors influencing the long-term results of autologous microvascular submandibular gland transplantation for severe dry eye disease

Zhang

Cai

et al. 2019

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

“…The latent period lasted for about 3 months, with little or no lubrication in the eyes. The Wharton's duct of the transplanted SMG may be obstructed without saliva flow over a long period, leading to surgical failure [18,42]. Beyond the "stable period", a large percentage of patients complained of too much secretion from the graft, aggravated by warmth or physical activity [28,37].…”

Section: Salivary Flow After Smg Transplantationmentioning

confidence: 99%

Salivary Gland Transplantation as a Promising Approach for Tear Film Restoration in Severe Dry Eye Disease

Chen,

Bai,

et al. 2024

JCM

Self Cite

View full text Add to dashboard Cite

With increased awareness of dry eye disease (DED), a multitude of therapeutic options have become available. Nevertheless, the treatment of severe DED remains difficult. In a patient whose DED is related to the loss of lacrimal function without severe destruction of the salivary glands, autologous transplantation of the latter as functioning exocrine tissue to rebuild a stable tear film is an attractive idea. All three major and minor salivary glands have been used for such transplantation. Due to the complications associated with and unfavorable prognosis of parotid duct and sublingual gland transplantation, surgeons now prefer to use the submandibular gland (SMG) for such procedures. The transplantation of the SMG not only has a high survival rate, but also improves dry eye symptoms and signs for more than 20 years post-surgery. The regulation of the secretion of the transplanted SMG is critical because the denervated SMG changes its mechanism of secretion. Innovative procedures have been developed to stimulate secretion in order to prevent the obstruction of the Wharton’s duct and to decrease secretion when postoperative “epiphora” occurs. Among the minor salivary glands, the transplantation of the labial salivary glands is the most successful in the long-term. The measurement of the flow rates of minor salivary glands and donor-site selection are critical steps before surgery.

show abstract

“…As such, the surgery has not gained widespread use at this point in time. The transplants can also cause chronic inflammation exacerbating dry eye symptoms, microcystic epithelial edema, and epiphora in approximately 40% of patients within 3–6 months of surgery [ 112 , 113 ]. While transplantation of these glands has shown great effect on dry eye and produce more natural tears than artificial instilled ones, the complicated surgery and risk of graft failure are staggering complications to overcome making them less than ideal.…”

Section: Emerging Therapies For Dry Eyementioning

confidence: 99%

Review: The Lacrimal Gland and Its Role in Dry Eye

Conrady

Joos

Patel

2016

Journal of Ophthalmology

127

108

View full text Add to dashboard Cite

The human tear film is a 3-layered coating of the surface of the eye and a loss, or reduction, in any layer of this film may result in a syndrome of blurry vision and burning pain of the eyes known as dry eye. The lacrimal gland and accessory glands provide multiple components to the tear film, most notably the aqueous. Dysfunction of these glands results in the loss of aqueous and other products required in ocular surface maintenance and health resulting in dry eye and the potential for significant surface pathology. In this paper, we have reviewed products of the lacrimal gland, diseases known to affect the gland, and historical and emerging dry eye therapies targeting lacrimal gland dysfunction.

show abstract

Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction

Abstract: Obstructive sialadenitis of transplanted SMGs is a chronic inflammation secondary to ductal obstruction, which leads to insufficient ocular lubrication and potential treatment failure.

Cited by 13 publications

References 21 publications

Factors influencing the long-term results of autologous microvascular submandibular gland transplantation for severe dry eye disease

Factors influencing the long-term results of autologous microvascular submandibular gland transplantation for severe dry eye disease

Salivary Gland Transplantation as a Promising Approach for Tear Film Restoration in Severe Dry Eye Disease

Review: The Lacrimal Gland and Its Role in Dry Eye

Contact Info

Product

Resources

About