Obstructive sleep apnea and hormones – a novel insight

Ruchała, Marek; Bromińska, Barbara; Cyrańska-Chyrek, Ewa; Kuźnar-Kamińska, Barbara; Kostrzewska, Magdalena; Batura‐Gabryel, Halina

doi:10.5114/aoms.2016.61499

Cited by 20 publications

(14 citation statements)

References 83 publications

(81 reference statements)

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“…There is evidence that weight loss can reduce SDB in obese patients [38]. Children with obesity are more vulnerable to sleep fragmentation and arousal induced by respiratory events leading to short sleep durations and chronic sleep deprivation [39,40]. Some evidence showed a strong association between poor sleep and obesogenic eating behavior; however, the underlying mechanism is not well understood [41].…”

Section: Discussionmentioning

confidence: 99%

Brain-derived neurotrophic factor in relation to central obesity in children with sleep disordered breathing

et al. 2021

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Introduction: Sleep disordered breathing (SDB) represents common comorbidities of childhood obesity leading to interrupted sleep and sleep deprivation. Sleep deprivation alters secretion of brain-derived neurotrophic factor (BDNF), which is an appetite regulator. However, little is known about the relation between BDNF and central obesity in children with SDB. The aim of the study was to evaluate BDNF level and anthropometric indices in relation to SDB in children with obesity Material and methods: A prospective case-control study was conducted on 30 children with obesity (BMI > 95 th percentile) and 30 healthy lean children (BMI 5 th-85 th percentile). Polysomnographic, anthropometric data and BDNF serum level were obtained from all included children. Serum level of BDNF and anthropometric indices of obesity were assessed in relation to SDB in children with obesity. Regression analysis was done to determine predictors for SDB in children with obesity. Results: In comparison to healthy controls, anthropometric indices of central obesity were significantly higher while BDNF was significantly lower in obese children, especially those with SDB. Respiratory disturbance index has a significant positive correlation with anthropometric indices of central obesity and a significant negative correlation with BDNF level. Central obesity and decreased BDNF were associated with 2-fold increased risk for SDB. Waist circumference/height ratio and neck circumference/height ratio have 89.5%, 75% sensitivity and 81.23%, 84.62% specificity at a cutoff point > 0.62, > 0.24 respectively for prediction of SDB in children with obesity. Conclusions: Central obesity and decreased BDNF represent independent predictors for SDB in children with obesity. Anthropometric indices adjusted to height are a simple screening tool for SDB in obese children.

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Section: Discussionmentioning

confidence: 99%

Brain-derived neurotrophic factor in relation to central obesity in children with sleep disordered breathing

et al. 2021

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“…This steroid not only plays a vital role in bone formation, but is also believed to have anticancer and anti--inflammatory properties. 16 YKL -40 has been implicated in inflammation, endothelial dysfunction, and tissue remodeling. It was also shown to be associated with the presence and severity of OSA.…”

Section: Discussionmentioning

confidence: 99%

Connection between bone remodeling and inflammatory markers in obstructive sleep apnea in relation to disease severity: a preliminary study

Bromińska¹,

Cyrańska-Chyrek²,

Kuźnar-Kamińska³

et al. 2017

Polish Archives of Internal Medicine

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INTRODUCTION There is growing evidence that obstructive sleep apnea (OSA) influences both bone metabolism and structure. Chitinase‑3‑like protein 1 (YKL‑40) is a novel inflammatory and remodeling marker, the levels of which were shown to increase in OSA. YKL‑40 can probably alter the bone turnover. OBJECTIVES The aim of the study was to assess a possible interplay between YKL‑40 and bone turnover markers in patients with different stages of OSA, and to evaluate the relation between bone mass, severity of OSA, and YKL‑40 levels. PATIENTS AND METHODS The study involved 72 male patients with OSA. They were divided into 3 groups according to disease severity, using the apnea-hypopnea index (AHI): group 1 (n = 18; 5≤ AHI <15), group 2 (n = 25; 15≤ AHI <30), and group 3 (n = 29; AHI ≥30). All patients underwent polysomnography and densitometry. Fasting blood samples were collected for YKL‑40, C‑terminal telopeptide of typeI collagen (CTX), procollagen type 1 N‑terminal propeptide (P1NP), and other markers. RESULTS P1NP differed between groups 1 and 2, as well as groups 1 and 3 (P = 0.02). Group 2 had higher CTX levels than group 1 (borderline significance, P = 0.05). A simple linear regression analysis showed that serum YKL‑40 levels were associated with the levels of CTX (P <0.0001, β = 0.9871) and P1NP (P <0.0001, β = 0.9780). CONCLUSIONS Our study might suggest that YKL‑40 is associated with bone turnover in OSA. We may assume that this marker influences both bone formation and destruction; thus, OSA could be characterized by preserved bone mineral density.

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“…It is possible that OSA disturbs this rhythm via the decreased quality and quantity of sleep. A negative correlation has been noticed between OSA severity and testosterone levels 4 . Also, obesity is very common in OSA patients.…”

Section: Introductionmentioning

confidence: 94%

“…OSA, obesity and hypogonadism are involved in a sequence of reciprocal cause and effect. Additionally, it is possible that OSA and obesity lead to inflammation and decreases in testosterone levels 4,5 . Following the reported relationships, our study aimed to investigate the potential role of anti-inflammatory protein nesfatin-1 as a mediator of HPG axis disturbances in OSA.…”

Section: Introductionmentioning

confidence: 99%

Does nesfatin-1 influence the hypothalamic–pituitary–gonadal axis in adult males with obstructive sleep apnoea?

Batura‐Gabryel

Bromińska

Sawicka‐Gutaj

et al. 2019

Sci Rep

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There is growing evidence that obstructive sleep apnoea (OSA) influences the hypothalamic–pituitary–gonadal axis (HPG axis) in men. The aim of the study was to assess the association of nesfatin-1 with HPG axis disturbances in OSA. This is a prospective study with consecutive enrolment. It comprises 72 newly diagnosed OSA patients ((AHI: apnoea-hypopnea index) 18 subjects: 5 ≤ AHI < 15; 24: 15 ≤ AHI < 30; 30: AHI ≥ 30) and a control group composed of 19 patients (AHI < 5). All patients underwent polysomnography and fasting blood collection for nesfatin-1, testosterone, luteinising hormone (LH), high-sensitivity C-reactive protein (hsCRP), aspartate transaminase (AST), alanine aminotransferase (ALT), creatinine and glucose. Groups had similar levels of LH, nesfatin-1 and testosterone (p = 0.87; p = 0.24; p = 0.08). Nesfatin-1 was not correlated to LH (p = 0.71), testosterone (p = 0.38), AHI (p = 0.34) or the oxygen desaturation index (ODI) (p = 0.69) either in the whole group, or in sub-groups. The study did not reveal any association between the HPG axis and nesfatin-1 in OSA adult males. It is possible that nesfatin-1 is not a mediator of HPG axis disturbances in adult patients with OSA.

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Obstructive sleep apnea and hormones – a novel insight

Cited by 20 publications

References 83 publications

Brain-derived neurotrophic factor in relation to central obesity in children with sleep disordered breathing

Brain-derived neurotrophic factor in relation to central obesity in children with sleep disordered breathing

Connection between bone remodeling and inflammatory markers in obstructive sleep apnea in relation to disease severity: a preliminary study

Does nesfatin-1 influence the hypothalamic–pituitary–gonadal axis in adult males with obstructive sleep apnoea?

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