Obstructive Sleep Apnea and Hypertension

Konečný, Tomáš; Kára, Tomáš; Somers, Virend K.

doi:10.1161/hypertensionaha.113.00613

Cited by 186 publications

(157 citation statements)

References 72 publications

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“…These 2 conditions frequently coexist (an estimated 50% of patients with hypertension have concomitant obstructive sleep apnea), and recent evidence supports the notion that obstructive sleep apnea represents the most prevalent secondary contributor to elevated blood pressure in patients with resistant hypertension. 16 …”

Section: Extractmentioning

confidence: 99%

Hypertension Editors’ Picks

2016

Hypertension

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Considering that we spend about one third of our lives asleep, it is no surprise that the patterns of sleep and circadian rhythms significantly influence our biology and health. Nighttime blood pressure (BP) has consistently been shown to predict target organ damage and outcomes as well or better than any other BP variable. The lack of a fall in BP during sleep, nondipping, is associated with secondary forms of BP, steroids, and worse outcomes than with the normal diurnal variation in BP.Sleep apnea is of particular interest in hypertension research. It is common in people with hypertension, reported in 40% to 50%. The question is whether this is causal or whether common factors predispose to both hypertension and sleep apnea. One way of addressing this is to treat sleep apnea and observe the changes in BP and in cardiovascular outcomes. Positive airways pressure, the best available therapy, has been shown to reduce BP by only a few mm Hg, and we await the well-powered outcome studies to be reported in 2016. In the meantime, Hypertension has been fortunate to publish a fascinating collection of papers on the cardiovascular aspects of sleep from basic mechanisms to a clinical review.

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Section: Extractmentioning

confidence: 99%

Hypertension Editors’ Picks

2016

Hypertension

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“…16 Well-conducted prospective non-HCM studies link increasing BP and incident hypertension with the presence and severity of SDB, independent of confounding variables (especially age, sex, and obesity). 17 Th e physiologic nocturnal decrease in BP is attenuated in patients with SDB, resulting in the so called nondipping BP pattern. Treatment of SDB leads to a relatively modest, but signifi cant reduction in BP, 18 and this conclusion is supported by several meta-analyses on the topic.…”

Section: Hypertensionmentioning

confidence: 99%

Sleep-Disordered Breathing in Hypertrophic Cardiomyopathy

Konečný

Somers

2014

Chest

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Sleep-disordered breathing (SDB) may be a treatable risk factor in patients with hypertrophic cardiomyopathy (HCM), the most common inherited cardiomyopathy. Evidence suggests a high prevalence of SDB in HCM. We summarize the pathophysiology of SDB as it relates to hypertension, coronary artery disease, atrial fi brillation, and sudden cardiac death in patients with HCM. The implications regarding the care of patients with HCM and SDB are discussed as well as the knowledge defi cits needing further exploration.CHEST 2014; 146 ( 1 )

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“…First of all, OSAS is commonly associated with the development of arterial hypertension, often occurring as resistant hypertension [19]. During the apneic event, the hypoxia may cause an imbalance between the myocardial oxygen demand and supply, which may induce myocardial ischemia or arrhythmias [12].…”

Section: Introductionmentioning

confidence: 99%

Lipid peroxidation and nitric oxide metabolites in a group of subjects with obstructive sleep apnea syndrome

Caimi

Presti

Montana

et al. 2016

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Abstract. It is known that in OSAS the plasma lipid peroxidation has an opposite behavior in comparison with nitric oxide metabolites. In the re-examination of our survey of OSAS subjects we calculated the ratio between thiobarbituric acid reactive substances (TBARS) and nitric oxide metabolites (NOx) in relation to OSAS severity. The study has regarded 48 OSAS subjects subdivided in two subgroups according to the apnea/hypopnea index -AHI-(Low = 21 subjects with AHI <30 and High = 27 subjects with AHI >30). From the obtained data it is evident that the TBARS/NOx ratio is significantly higher in the H subgroup compared to L subgroup as well as this ratio is reduced in L subgroup in comparison with the whole group of OSAS subjects. In the entire group of OSAS subjects the TBARS/NOx ratio results positively correlated with AHI and ODI and inversely correlated with mSO 2 .

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Obstructive Sleep Apnea and Hypertension

Cited by 186 publications

References 72 publications

Hypertension Editors’ Picks

Hypertension Editors’ Picks

Sleep-Disordered Breathing in Hypertrophic Cardiomyopathy

Lipid peroxidation and nitric oxide metabolites in a group of subjects with obstructive sleep apnea syndrome

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