Obstructive sleep apnea and vitamin D level: Has the dust settled?

Loh, Huai Heng; Sukor, Norlela

doi:10.1111/crj.13593

Cited by 3 publications

(4 citation statements)

References 118 publications

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“…This hypothesis is further supported by the fact that higher adherence to CPAP treatment is associated with higher levels of 25(OH)D [31], and by recently published data from our research group showing that serum 25(OH)D levels are negatively correlated with plasma high-sensitivity C-reactive protein in the same cohort [32]. In addition, vitamin D levels were inversely correlated with sleep stage transitions, indicating the role of sleep fragmentation in VDD [11].…”

Section: Discussionsupporting

confidence: 57%

“…Interestingly, VDD predicted OSA severity in the group of older participants (≥50 y), but not in younger adults. OSA and VDD appear to have overlapping risk factors, including obesity and advancing age, and it is noteworthy that older adults typically exhibit lower vitamin D levels, as aging itself constitutes an independent risk factor for VDD [11].…”

Section: Discussionmentioning

confidence: 99%

“…Skeletal muscle impairment is common in OSA, contributing to respiratory disturbances during sleep [37]. VDD may exacerbate muscle dysfunction, potentially impacting respiratory muscle strength and contributing to the severity of OSA [11]. It has been reported that a decline in the strength of the pharyngeal dilator muscles due to VDD may diminish pharyngeal patency, increasing susceptibility to apneic events during sleep [38].…”

Section: Discussionmentioning

confidence: 99%

“…However, the exact mechanism of VDD in adults with OSA and the correlation between vitamin D levels and OSA severity remain ambiguous, with contradictory results in clinical studies [11]. A common challenge is the variability in methodologies for assessing both vitamin D levels and OSA severity, hindering the generalizability of the findings.…”

Section: Introductionmentioning

confidence: 99%

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Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea

Kechribari,

Kontogianni,

Georgoulis

et al. 2024

Life

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Vitamin D deficiency (VDD) may be associated with obstructive sleep apnea (OSA) presence and is more pronounced with increasing OSA severity; however, the relationship between these two entities remains unclear. This was a cross-sectional study among 262 adults with in-hospital-attended polysomnography-diagnosed OSA and no additional major comorbidities, aiming to explore possible associations between serum 25-hydroxyvitamin D [25(OH)D] levels and polysomnographic parameters. Data on demographics, medical history, anthropometric indices, and lifestyle habits were collected at enrolment. Serum 25(OH)D was evaluated using chemiluminescence, with VDD defined as 25(OH)D < 20 ng/mL. VDD was observed in 63% of the participants. Serum 25(OH)D correlated negatively with apnea–hypopnea index and other polysomnographic indices (all p < 0.05). In logistic regression analysis, adjusting for age, sex, smoking, body mass index, physical activity, dietary vitamin D intake, and season of blood sampling, serum 25(OH)D was associated with lower odds of severe OSA [odds ratio (95% confidence interval): 0.94 (0.90–0.98)]. In the same multivariate model, VDD was associated with ~threefold higher odds of severe OSA [2.75 (1.38–5.48)]. In stratified analyses, VDD predicted OSA severity in the group of participants ≥50 y [3.54 (1.29–9.68)] and among those with body mass index ≥ 30 kg/m2 [3.38 (1.52–7.52)], but not in the younger and non-obese adults. This study provides further evidence of an inverse association between vitamin D levels and OSA severity and underscores the importance of considering vitamin D status as a potential modifiable factor in the comprehensive management of OSA.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea

Kechribari,

Kontogianni,

Georgoulis

et al. 2024

Life

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Obstructive sleep apnea and vitamin D: an updated systematic review and meta-analysis

Loh,

Lim,

Kang

et al. 2023

Hormones

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The Serum 25(OH) Vitamin D, Calcium, and Parathyroid Hormone Levels of The Patients With The Obstructive Sleep Apnea Syndrome

Yalim,

Matyar,

Yalım

2024

J Cukurova Anesth Surg

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Background: Although there is evidence linking vitamin D to many neurochemical processes involved in sleep, the association between the obstructive sleep apnea and vitamin D, calcium and parathyroid hormone is still unknown, as clinical research have shown inconsistent findings. In this study, we aimed to examine the hypothesis that if there is any relationship between obstructive sleep apnea and serum vitamin D, calcium and parathyroid hormone levels in order to manage treatment. Methods: 56 patients (32 male, 24 female) admitted to the University of Health Sciences Adana City Training and Research Hospital otorhinolaryngology clinic between January 1st, 2022 and January 1st 2023 without any acute and chronic disease were included in the study. The range of participants was 18-70. In this study we examined the serum vitamin D, calcium and parathyroid hormone levels of 32 obstructive sleep apnea patients and compared their serum vitamin D, calcium and parathyroid hormone levels with the serum vitamin D, calcium and parathyroid hormone levels of 24 normal patients in the control group. Results: When the serum vitamin D, calcium and parathyroid hormone levels of obstructive sleep apnea patients and serum vitamin D, calcium and parathyroid hormone levels of normal patients were compared we did not find a statistically significant difference which may be due to our patient density. Conclusion: Vitamin D, calcium and parathyroid hormone levels are not likely related to the presence or absence of obstructive sleep apnea. More intervention studies are needed to better clarify the relation between the obstructive sleep apnea and vitamin D, calcium and parathyroid hormone.

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Obstructive sleep apnea and vitamin D level: Has the dust settled?

Cited by 3 publications

References 118 publications

Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea

Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea

Obstructive sleep apnea and vitamin D: an updated systematic review and meta-analysis

The Serum 25(OH) Vitamin D, Calcium, and Parathyroid Hormone Levels of The Patients With The Obstructive Sleep Apnea Syndrome

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