Obstructive sleep apnea, depression and cognitive impairment

Vaněk, Jakub; Praško, Ján; Genzor, Samuel; Ocisková, Marie; Kantor, Kryštof; Holubová, Michaela; Šlepecký, Miloš; Nesnídal, Vlastimil; Kolek, Antonín; Sova, Milan

doi:10.1016/j.sleep.2020.03.017

Cited by 165 publications

(117 citation statements)

References 110 publications

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“…Finally, to which extent sleep apnea and chronic intermittent hypoxia, which are known to result in cognitive impairment [26] and also to be associated with the metabolic syndrome and NAFLD/NASH [27], contributes to the cognitive impairment found in NAFLD still remains to be elucidated.…”

Section: Cognitive Impairmentmentioning

confidence: 99%

Depression and Cognitive Impairment—Extrahepatic Manifestations of NAFLD and NASH

2020

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Non-alcoholic fatty liver disease (NAFLD) and its complication non-alcoholic steatohepatitis (NASH) are important causes of liver disease worldwide. Recently, a significant association between these hepatic diseases and different central nervous system (CNS) disorders has been observed in an increasing number of patients. NAFLD-related CNS dysfunctions include cognitive impairment, hippocampal-dependent memory impairment, and mood imbalances (in particular, depression and anxiety). This review aims at summarizing the main correlations observed between NAFLD development and these CNS dysfunctions, focusing on the studies investigating the mechanism(s) involved in this association. Growing evidences point at cerebrovascular alteration, neuroinflammation, and brain insulin resistance as NAFLD/NASH-related CNS manifestations. Since the pharmacological options available for the management of these conditions are still limited, further studies are needed to unravel the mechanism(s) of NAFLD/NASH and their central manifestations and identify effective pharmacological targets.

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Section: Cognitive Impairmentmentioning

confidence: 99%

Depression and Cognitive Impairment—Extrahepatic Manifestations of NAFLD and NASH

2020

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“…However, we have to consider the bidirectional relationship between these variables and PSED. Indeed primary sleep disorders such as obstructive sleep apnea syndrome or vascular cognitive impairment are independent sources of impaired mood (Douven et al, 2018;Vanek et al, 2020). These strong associations still reinforce the need of a standardized evaluation of each potential source of PSED in order to optimize their pharmacological and nonpharmacological management.…”

Section: Discussionmentioning

confidence: 99%

Association between neurological outcome and poststroke comorbid mood and anxiety disorders: A real‐life experience

et al. 2021

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“…Depressive symptoms and cognitive impairments are frequently observed in OSA patients [19]. Sleep quality was associated with depression, anxiety, and stress [20].…”

Section: Discussionmentioning

confidence: 99%