Obstructive sleep apnea during acute coronary syndrome is related to myocardial necrosis and wall stress

Cheong, Crystal Sj.; Aung, Aye-Thandar; Wong, Raymond; Yeo, Tee Joo; Chan, Siew‐Pang; Lee, Chi‐Hang

doi:10.1016/j.sleep.2021.01.006

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…Second, the increased intrathoracic pressure changes during apneas and hypopneas may lead to subclinical myocardial injury (Javaheri et al, 2017). Cardiac TnI is strongly associated with CVD risk and has previously been independently associated with higher AHI, both in the general population and in patients with OSA presenting with acute myocardial infarction (Cheong et al, 2021;Einvik et al, 2014). Increased AHI has previously been associated with detectable high-sensitivity cTnT in the ASAP, but this association was attenuated when adjusted for hypertension (Randby et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project

Sigurdardottir

Øverby

Nikkonen

et al. 2022

Journal of Sleep Research

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Novel diagnostic markers for obstructive sleep apnea beyond the apnea-hypopnea index (AHI) have been introduced. There are no studies on their association with markers of subclinical myocardial injury. We assessed the association between novel desaturation parameters and elevated cardiac troponin I and T. Participants with polysomnography (498) from the Akershus Sleep Apnea study were divided into normal and elevated biomarker groups based on sex-specific concentration thresholds (cardiac troponin I: ≥4 ng/L for women, ≥6 ng/L for men; and cardiac troponin T: ≥7 ng/L for women, ≥8 ng/L for men). Severity of obstructive sleep apnea was evaluated with the AHI, oxygen desaturation index, total sleep time with oxygen saturation below 90% (T90), lowest oxygen saturation (Min SpO 2 %), and novel oxygen desaturation parameters: desaturation duration and desaturation severity. How the AHI and novel desaturation parameters predicted elevated cardiac troponin I and cardiac troponin T levels was assessed by the area

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Section: Discussionmentioning

confidence: 99%

Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project

Sigurdardottir

Øverby

Nikkonen

et al. 2022

Journal of Sleep Research

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Sleep apnea prevalence and severity after coronary revascularization versus no intervention: a systematic review & meta-analysis

Marjo,

Satu,

Tero

et al. 2024

Sleep Breath

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Purpose Obstructive sleep apnea (OSA) is a common disease in patients with coronary artery disease (CAD). Approximately 40–80% of cardiovascular disease patients have obstructive sleep apnea. The manifestation of it can vary significantly in different types of CAD patients. This systematic review and meta-analysis investigate the prevalence and severity of OSA in patients with acute coronary syndrome (ACS). Methods This systematic review was conducted according to PRISMA guidelines. The first inclusion criteria were that a reliable sleep study had to be done after treating the patients’ acute coronary incident. All patients in the studies included were adults suffering from an ACS who underwent either coronary artery bypass grafting surgery (CABG), a percutaneous coronary intervention (PCI) or had no invasive coronary intervention done. A search was conducted within four valid databases 27.1.2023 and all suitable articles published after 1.1.2010 were included. Results Eight studies fulfilled the full inclusion criteria. In five of them, a sleep study had been performed after PCI, in two after no coronary intervention, and in one study after CABG. Mean AHI in no-OSA group after PCI was 9.5 /h (95% CI 5.3–13.7) and in the no intervention group 6.4 /h (95% CI 3.5–9.4). In OSA patients, mean AHI after PCI was 34.9 /h (95% CI 25.9–43.8) vs. 24.1 /h without intervention (95% CI 15.6–32.6). Conclusions Sleep apnea is very common among ACS patients and should be screened for and addressed after the acute coronary intervention. Moreover, we found that OSA is more severe in patients in whom PCI for ACS was indicated as opposed to patients who underwent no coronary intervention.

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Obstructive sleep apnea and cardiac biomarkers in patients with acute coronary syndrome

Kawada

2021

Sleep Medicine

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Obstructive sleep apnea during acute coronary syndrome is related to myocardial necrosis and wall stress

Cited by 4 publications

References 13 publications

Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project

Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project

Sleep apnea prevalence and severity after coronary revascularization versus no intervention: a systematic review & meta-analysis

Obstructive sleep apnea and cardiac biomarkers in patients with acute coronary syndrome

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