Obstructive Sleep Apnea in Women: Specific Issues and Interventions

Wimms, Alison; Woehrle, Holger; Ketheeswaran, Sahisha; Ramanan, Dinesh; Armitstead, Jeff

doi:10.1155/2016/1764837

Cited by 131 publications

(109 citation statements)

References 93 publications

(117 reference statements)

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“…40 Differences in fat distribution, upper airway size and collapsibility, and ventilatory control between men and women have also been implicated in sex difference in OSA prevalence. 41,42 However, our studies in South Asians with T2DM do not show any sex difference in OSA prevalence. In our study, South Asian women were more obese (based on BMI and waist circumference) than South Asian men and this, together with differences in adiposity distribution, might have contributed to the lack of sex difference.…”

Section: Discussioncontrasting

confidence: 67%

Prevalence and Associations of Obstructive Sleep Apnea in South Asians and White Europeans with Type 2 Diabetes: A Cross-Sectional Study

Amin

Ali

Altaf

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives:To assess and compare obstructive sleep apnea (OSA) prevalence in South Asians and White Europeans with type 2 diabetes mellitus (T2DM). Secondary aims included exploring possible causes for observed ethnic differences. Methods: A cross-sectional study of patients with T2DM recruited from secondary care diabetes clinics. OSA was defined as an apnea-hypopnea index (AHI) ≥ 5 events/h using home-based, multi-channel respiratory monitoring. Results: Two hundred thirty-four patients (105 South Asian and 129 White Europeans) were studied. The prevalence of mild, moderate, and severe OSA in South Asians was 36.2% (n = 38/105), 9.5% (n = 10/105), and 5.7% (n = 6/105) respectively. After adjustment, OSA was associated with a higher body mass index in South Asians. OSA was significantly less common in South Asians compared to White Europeans Conclusions: South Asians with T2DM are at considerable risk of OSA. OSA in South Asians was associated with obesity. However, OSA prevalence was lower in South Asians than in White Europeans. Obesity measures accounted for the observed ethnic differences. Examining factors contributing to ethnic differences will be important to inform screening and treatment strategies. Keywords: ethnicity, obesity, sleep apnea, type 2 diabetes Citation: Amin A, Ali A, Altaf QA, Piya MK, Barnett AH, Raymond NT, Tahrani AA. Prevalence and associations of obstructive sleep apnea in South Asians and White Europeans with type 2 diabetes: a cross-sectional study.

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Section: Discussioncontrasting

confidence: 67%

Prevalence and Associations of Obstructive Sleep Apnea in South Asians and White Europeans with Type 2 Diabetes: A Cross-Sectional Study

Amin

Ali

Altaf

et al. 2017

Journal of Clinical Sleep Medicine

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“…Analyses adjusted for obesity, a major SDB risk factor, identified loci and genes implicated in pulmonary, inflammatory, and craniofacial pathways. Some associations were population-specific, while others were sex-specific, consistent with population differences and strong sex differences for SDB [ 24,[68][69][70] ]. Notably, across multiple ancestral groups, we identified a set-based rare-variant association (p = 3.48 × 10 -8 ) on chromosome X with ARMCX3.…”

Section: Discussionmentioning

confidence: 65%

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

Cade

Lee

Sofer

et al. 2019

Preprint

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Sleep-disordered breathing (SDB) is a common disorder associated with significant morbidity. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program we report the first whole-genome sequence analysis of SDB. We identified 4 rare gene-based associations with SDB traits in 7,988 individuals of diverse ancestry and 4 replicated common variant associations with inclusion of additional samples (n=13,257). We identified a multi-ethnic set-based rare-variant association (p = 3.48 × 10 -8 ) on chromosome X with ARMCX3.Transcription factor binding site enrichment identified associations with genes implicated with respiratory and craniofacial traits. Results highlighted associations in genes that modulate lung development, inflammation, respiratory rhythmogenesis and HIF1A-mediated hypoxic response.

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“…Sex differences have also been noted in the prevalence and severity of OSA, with women presenting with less severe and less prevalent disease. These differences are decreased after menopause [31]. Differences in fat distribution, upper airway anatomy (in particular the Renal Function = renal function was estimated by lab data containing the most recently recorded eGFR.…”

Section: Discussionmentioning

confidence: 99%

Obstructive sleep apnea and the risk of gout: a population-based case-control study

et al. 2020

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Background: Patients with obstructive sleep apnea (OSA) might be at risk of gout because of pathophysiological mechanisms that can lead to hyperuricemia and eventually gout or because of shared risk factors between both diseases. The objective of the present study was to investigate the risk of gout in patients with OSA. Methods: A population-based case-control study using the UK Clinical Practice Research Datalink GOLD including all patients aged 40 years and older with a first diagnosis of gout between 1987 and 2014. Gout cases were matched by year of birth, sex, and practice to non-gout controls. Conditional logistic regression estimated the risk of gout with an earlier diagnosis of OSA. Analyses were adjusted for lifestyle factors, comorbidities, and recent drug use. Results: One hundred eleven thousand five hundred nine cases were matched with 210,241 controls. Patients with OSA were at increased risk of gout (OR 1.86; 95%CI (1.71-2.02). However, this association disappeared (OR 1.05; 95% CI 0.96-1.16) after adjustment for smoking status, body mass index (BMI), alcohol use, a history of heart failure, diabetes mellitus, renal function, and recent use of diuretics and other medications. Among females with OSA and patients with OSA associated with heart failure, renal impairment, or higher BMI, the risk of gout was however still increased when compared to the total control population. Conclusion: This study showed that the observed association between OSA and gout disappeared after adjustment.

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Obstructive Sleep Apnea in Women: Specific Issues and Interventions

Cited by 131 publications

References 93 publications

Prevalence and Associations of Obstructive Sleep Apnea in South Asians and White Europeans with Type 2 Diabetes: A Cross-Sectional Study

Prevalence and Associations of Obstructive Sleep Apnea in South Asians and White Europeans with Type 2 Diabetes: A Cross-Sectional Study

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

Obstructive sleep apnea and the risk of gout: a population-based case-control study

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