Obstructive sleep apnea is common in patients with interstitial lung disease

Pıhtılı, Aylin; Bingöl, Züleyha; Kıyan, Esen; Çuhadaroğlu, Çağlar; İşsever, Halim; Gulbaran, Ziya

doi:10.1007/s11325-013-0834-3

Cited by 113 publications

(130 citation statements)

References 27 publications

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“…15 (44%) subjects had mild and five (15%) had moderate-to-severe OSA, while 14 (41%) subjects were normal. The last study showing again that OSA is a common comorbidity in IPF was a study from Turkey by PIHTILI et al [25]. Based on these studies, the incidence of OSA is high in IPF patients, even though it should be mentioned that IPF is known to occur mostly in those over the age of 60 years, an age where OSA increases even among normal people.…”

Section: Sleep In Ipfmentioning

confidence: 99%

“…As stated in the previous sections, there is a wide variability in the reported prevalence of OSA in ILD patients, from 17% to 88%, probably depending on a range of differences in the populations studied, including different referral patterns, prevalence of obesity, ethnicity and corticosteroid treatment [18,23,25,54,55]. However, a significant proportion of patients with IPF have overnight oxygen desaturation independently of the presence of OSA.…”

Section: Nocturnal Hypoxia and Supplemental Oxygen In Ipfmentioning

confidence: 99%

“…The main complaint in IPF patients with OSA is daytime fatigue, a complaint with a multifactorial profile that is difficult to assess [11,24]. In addition, based on the recent PSG studies in this population, the majority of the respiratory events are hypopnoeas and the accurate recognition of these needs special equipment and follows new terminology [13,[23][24][25].…”

Section: Sleep In Ipfmentioning

confidence: 99%

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Idiopathic pulmonary fibrosis and sleep disorders: no longer strangers in the night

et al. 2015

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The prevalence of obstructive sleep apnoea (OSA) is continuously increasing in patients with idiopathic pulmonary fibrosis (IPF) and, for the first time, the recent IPF guidelines recognise OSA as an important associated comorbidity that can affect patient's survival. Thus, it becomes conceivable that clinicians should refer patients with newly diagnosed IPF to sleep centres for the diagnosis and treatment of OSA as well as for addressing issues regarding the reduced compliance of patients with continuous positive airway pressure therapy. The discovery of biomarkers common to both disorders may help early diagnosis, institution of the most appropriate treatment and follow-up of patients. Better understanding of epigenetic changes may provide useful information about pathogenesis and, possibly, development of new drugs for a dismal disease like IPF. @ERSpublications It is now believed that IPF and sleep disorders can coexist in the same patient

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Section: Sleep In Ipfmentioning

confidence: 99%

Section: Nocturnal Hypoxia and Supplemental Oxygen In Ipfmentioning

confidence: 99%

Section: Sleep In Ipfmentioning

confidence: 99%

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Idiopathic pulmonary fibrosis and sleep disorders: no longer strangers in the night

et al. 2015

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“…İAH ve OUAS birlikteliğinde OUAS ile ilişkili tekrarlayan oksijen desatürasyonaları nedeniyle altta yatan akciğer hastalığının progresyonu hızlanır (6). Genellikle idiyopatik pulmoner fibrozis (İPF) hastalarının değerlendirildiği İAH ve uyku bozuklukları çalışmalarında OUAS sıklığı, %17-88 arasında değişen oranlarda saptanmıştır (7)(8)(9)(10)(11). Bu birliktelik aydınlatılması gereken ve daha ayrıntılı çalışmalara ihtiyaç duyulan bir konudur.…”

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Evaluation of Sleep Related Breathing Disorders and Obstructive Sleep Apne Syndrome in Interstitial Lung Patients

Hanci¹,

Alpaydın²,

İtil³

et al. 2016

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Objective:Interstitial lung disease (ILD) may create sleep disturbances due to chronic disease-related stress, respiratory abnormalities and adverse effects of treatment. We aimed to determine the quality of sleep in ILD patients, and the incidence of Obstructive sleep apnea syndrome (OSAS) in these patients. Materials and Methods: Taken to this study were 52 patients who were followed up in our center due to ILD. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were applied to the patients. Spirometry and diffusion test were performed. Polysomnography (PSG) was performed to 27 patients whose ESS were more than or equal to 10. Results: Demographic characteristics, body mass index, spirometry and diffusion measurements, PSQI global score and the sub-components of it didn't show difference according to ESS daytime sleepiness.

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In their article published in this issue of Sleep and Breathing, Pihtili et al [1] present polysomnographic data in patients with interstitial lung diseases (ILDs) including 17 patients with idiopathic pulmonary fibrosis (IPF), 15 patients with stage II-III sarcoidosis, and 18 patients with pulmonary fibrosis due to scleroderma. The study revealed a high prevalence, namely 68 %, of obstructive sleep apnea (OSA) in this population.

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confidence: 99%

Obstructive sleep apnea in patients with interstitial lung diseases: past and future

2013

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In their article published in this issue of Sleep and Breathing, Pihtili et al. [1] present polysomnographic data in patients with interstitial lung diseases (ILDs) including 17 patients with idiopathic pulmonary fibrosis (IPF), 15 patients with stage II-III sarcoidosis, and 18 patients with pulmonary fibrosis due to scleroderma. The study revealed a high prevalence, namely 68 %, of obstructive sleep apnea (OSA) in this population. The prevalence of OSA was 82.3 % in the IPF patients, 66.6 % in the sarcoidosis patients, and 55.5 % in the scleroderma patients. The OSA severity was mostly mild, while the scored respiratory events were predominantly hypopneas. An interesting feature of this study is that this increased incidence of OSA was observed after the exclusion of patients with well-known predisposing factors for OSA such as obesity and/or significant upper airway pathologies causing obstruction. The authors used a disease severity index consisting of body mass index, carbon monoxide diffusion capacity, the Modified Medical Research Council dyspnea scale, and the 6-min walking distance, with scores ranging between 0 and 10. The OSA diagnosis rate was higher in the patients who had severity index ≥3.The frequency and consequences of OSA in patients with interstitial lung diseases is a field of growing research over the last years, although the medical literature on this area still remains quite limited with significant contraries between the results of older and more recent studies [2]. Prior polysomnographic studies in the mid-1980s demonstrated alterations in sleep architecture and oxygen desaturation, especially during REM sleep, but not OSA, even in morbidly obese patients with ILDs [3,4]. The results of the study by Pihtili et al. related to IPF patients are similar to recent studies that report increased incidence of OSA and pointed the need for high clinical suspicion for possible underlying OSA in this population [5][6][7][8]. Prior studies dating back 10-20 years probably underestimated hypopneas by using only thermal sensors and not nasal pressure transducers which are recognized as the sensitive devices for hypopnea detection that represents the majority of the observed respiratory events in IPF patients based on the newer studies. Related to sarcoidosis, Pihtili et al. report significantly higher percentages of OSA compared to previous studies [9] while the only one published study in scleroderma [10] found no OSA contrary to the high percentages observed by Pihtili et al.The available data of the above-mentioned studies show that OSA is common in patients with ILDs, especially those with IPF. Restrictive pulmonary diseases are characterized by decreased lung volumes that can reduce the upper airway stability and increase resistance due to a decreased traction on the upper airway. These changes can facilitate the upper airway collapse, especially during REM sleep when functional residual capacity is further reduced due to the inactivity of the intercostal muscles.The morbidity and mortality of OSA...

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Obstructive sleep apnea is common in patients with interstitial lung disease

Abstract: OSA is common in ILD. PSG or at minimum nocturnal oximetry should be performed, particularly in patients with functionally and radiologically severe disease.

Cited by 113 publications

References 27 publications

Idiopathic pulmonary fibrosis and sleep disorders: no longer strangers in the night

Idiopathic pulmonary fibrosis and sleep disorders: no longer strangers in the night

Evaluation of Sleep Related Breathing Disorders and Obstructive Sleep Apne Syndrome in Interstitial Lung Patients

Obstructive sleep apnea in patients with interstitial lung diseases: past and future

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