Obstructive sleep apnea syndrome: effect of respiratory events and arousal on pulse wave amplitude measured by photoplethysmography in NREM sleep

Haba‐Rubio, José; Darbellay, Georges A.; Herrmann, Françoís; Frey, Jean G.; Fernandes, Alda; Vesin, J.-M.; Thiran, Jean-Philippe; Tschopp, Jean M.

doi:10.1007/s11325-005-0017-y

Cited by 64 publications

(47 citation statements)

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“…Moreover, these last authors recently showed better correlation between pulse wave amplitude changes and acoustical-induced arousals undetected by EEG than with other autonomic markers. In patients with SAS, we recently confirmed that RE and A induce more changes in PWA than changes in HR as measured by photoplethysmography [18]. We also found more changes in PWA than HR after RE without cortical arousal.…”

Section: Introductionsupporting

confidence: 67%

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Sleep apnea syndrome: improved detection of respiratory events and cortical arousals using oxymetry pulse wave amplitude during polysomnography

et al. 2007

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Respiratory events (RE) during sleep induce cortical arousals (A) and marked changes in autonomic markers in sleep apnea syndrome (SAS). The aims of the study were double. First, we assessed whether pulse wave amplitude (PWA) added to polysomnography (PSG) could improve RE and A detection; second, we wanted to know whether the quality of detection of these two parameters could be improved using PWA. Respiratory disturbance index (RDI) and A were randomly scored twice by the same observer in 12 male patients with SAS. The first scoring was done using conventional PSG signals, the second scoring adding PWA to PSG. We also measured interobserver agreement by randomly selecting and reading 100 PSG sequences of 5 min with and without PWA by two observers. Adding PWA to PSG parameters allowed to detect significantly more RDI (53.9 +/- 21.6 h(-1) versus 48.3 +/- 22.3 h(-1), p < 0.001) and more A (68.0 +/- 14.4 versus 59.4 +/- 16.5, p < 0.001). Moreover, after using PWA, there was no significant disagreement between two observers for detecting RE, showing better quality of RE detection. PWA is a simple and cheap parameter that improves the diagnostic value of conventional PSG in sleep apnea syndrome by better detecting respiratory events and A.

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Section: Introductionsupporting

confidence: 67%

“…Subtle subcortical or autonomic arousals seem also to play a role in SAS. RE not only induce arousals but also changes in autonomic markers such as heart rate (HR) [8,9], blood pressure [10], peripheral arterial tonometry (PAT) [11][12][13], pulse transit time (PTT) [14][15][16], and photoplethysmography [17,18].…”

Section: Introductionmentioning

confidence: 99%

Sleep apnea syndrome: improved detection of respiratory events and cortical arousals using oxymetry pulse wave amplitude during polysomnography

et al. 2007

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“…Since CAP probably reflects subcortical as well as cortical activation, finding this result suggests that the frequency of both cortical and subcortical arousals together might be better related to sleep quality than either alone. Although primary attention in doing this kind of analysis has focused mostly on EEG signal analysis, the difficulty in doing this may outweigh the simplicity of our approach which focuses on HR, rather than on harder to measure autonomic measures such as pulse wave transit time or pulse amplitude (Pitson and Stradling, 1998;Haba-Rubio et al, 2005). During REM sleep, bouts of tachycardia-bradycardia occur without any detectable change in the EEG power spectrum (Fig.…”

Section: Discussionmentioning

confidence: 99%

Electroencephalogram characteristics of autonomic arousals during sleep in healthy men

Togo

Cherniack

Natelson

2006

Clinical Neurophysiology

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Objective-Many sleep disorders involve frequent, brief arousals, not appreciated during conventional sleep stage scoring due to lack of electroencephalogram (EEG) desynchronization. We evaluated the temporal relation between heart rate (HR) changes, an index of autonomic activation, and EEG in seven healthy subjects during sleep.Methods-We identified bouts of tachycardia-bradycardia and performed spectral analysis of EEG during these. We also identified cortical arousals by the appearance of EEG alpha activity. This allowed us to dichotomize bouts of tachycardia-bradycardia by presence or absence of cortical arousal.Results-During non-rapid eye movement (REM) sleep, bouts with or without cortical arousal occurred with approximately equal frequency. Those with cortical arousals usually preceded onset of EEG changes. Those without cortical arousals were followed by increases in delta but not alpha power. EEG did not change during bouts in REM sleep.Conclusions-Capturing bouts of tachycardia-bradycardia is relatively easy via computerized algorithm. Bouts occur with cortical arousal or with slow wave synchronization suggestive of subcortical arousal. Thus, changes in HR may be useful index of arousal.Significance-These brief bursts of tachycardia-bradycardia are consistent with autonomic arousal. Such a measure may be among the first in a continuum of arousal ending with frank awakening.

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“…[18], and the PLMS index (PLMSI) was calculated. As autonomic arousals were considered, the pulse-wave amplitude (PWA) drops (of at least 30% of baseline PWA) obtained from finger photoplethysmography, reflecting peripheral vasoconstriction [19,20]. The number and index per hour of sleep of autonomic arousals were calculated.…”

Section: Polysomnographymentioning

confidence: 99%

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population

Haba‐Rubio

Frauscher

Marques‐Vidal

et al. 2017

Sleep

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Study Objectives: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography.Methods: Full polysomnographic data from 1,997 participants (age = 59 ± 11.1 years, 53.6% women) participating in a population-based study (HypnoLaus, Lausanne, Switzerland) were collected. Sleep-related complaints and habits were investigated using various sleep measures including the Munich Parasomnia Screening (MUPS) questionnaire, which includes two questions evaluating complex motor behaviors suggestive of RBD. Full polysomnography was performed at home. For participants screening positive for RBD, muscle activity during REM sleep was quantified to diagnose RBD.Results: Three hundred sixty-eight participants endorsed dream-enactment behavior on either of the two MUPS questions, and 21 fulfilled polysomnographic criteria for RBD, resulting in an estimated prevalence of 1.06% (95% CI = 0.61-1.50), with no difference between men and women. Compared with RBD− participants, RBD+ took more frequently antidepressants and antipsychotics (23.8% vs. 5.4%, p = .005; 14.3% vs. 1.5%, p = .004, respectively) and were more frequently smokers or exsmokers (85% vs. 56.6%, p = .011). On polysomnography, RBD+ had more stage N2 sleep (52 ± 11.5% vs. 46.3 ± 10.2%, p = .024) and less REM sleep (18 ± 6.4% vs. 21.9 ± 6.2%, p = .007), lower apnea-hypopnea index in REM sleep (3.8 ± 5.2 vs. 8.9 ± 13/hour, p = .035), and lower autonomic arousal index (31 ± 14.9 vs. 42.6 ± 19.5/hour, p = .002). Conclusions:In our middle-to-older age population-based sample, the prevalence of RBD was 1.06%, with no difference between men and women. RBD was associated with antidepressant and antipsychotic use and with minor differences in sleep structure.Key words: polysomnography; synucleinopathies; parasomnia; sleep; REM sleep without atonia Statement of SignificanceRapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia frequently associated or preceding neurodegenerative diseases such as synucleinopathies. Its occurrence in the general population is largely unknown. Analyzing data from 1,997 participants to the population-based HypnoLaus study who completed the Munich Parasomnia Screening questionnaire and had a complete polysomnography at home, we estimate the prevalence of RBD at 1.06%, with no significant difference between men and women. RBD was associated with antidepressant and antipsychotic use, and with minor differences in sleep structure. Knowing the prevalence and characteristics of RBD has important implications, as people with RBD can be ideal candidates for neuroprotective approaches, and can help us to better understand the progression of neurodegenerative disorders.

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Obstructive sleep apnea syndrome: effect of respiratory events and arousal on pulse wave amplitude measured by photoplethysmography in NREM sleep

Cited by 64 publications

References 28 publications

Sleep apnea syndrome: improved detection of respiratory events and cortical arousals using oxymetry pulse wave amplitude during polysomnography

Sleep apnea syndrome: improved detection of respiratory events and cortical arousals using oxymetry pulse wave amplitude during polysomnography

Electroencephalogram characteristics of autonomic arousals during sleep in healthy men

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population

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