Obstructive Sleep Apnoea Syndrome as a Systemic Low-Grade Inflammatory Disorder

Zamarrón, Carlos; Morete, Emilio; Campo, Félix del

doi:10.5772/32376

Cited by 3 publications

(5 citation statements)

References 177 publications

(141 reference statements)

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“…Recently, the concept of OSAS as a simple respiratory abnormality during sleep has been diverted to a systemic response due to multiple pathogenetic mechanisms of oxidative stress [26][27][28][29][30], increased sympathetic overactivity [31], coagulation fibrinolysis imbalance, and platelets activation [32]. All these factors lead to a state of systemic inflammation [4,[33][34][35], endothelial dysfunction [3], metabolic dysregulation [36], and hypercoagulability [32].…”

Section: Discussionmentioning

confidence: 99%

“…The exact mechanism of platelet activation in patients with OSAS is unclear and may be complex, Three main pathways may be implicated; sympathetic overactivity [59], hypoxia [60], and inflammation [61,62], all being well-known features of OSAS [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…This results in a reduction or complete cessation of the airflow that leads to arousals, sleep fragmentation, and oxyhemoglobin desaturation. Patients with OSAS undergo repetitive episodes of hypoxia and reoxygenation that may have systemic effects [1][2][3], so that, OSAS is considered a systemic inflammatory disease, not a local abnormality [4,5].…”

Section: Introductionmentioning

confidence: 99%

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The Severity of Obstructive Sleep Apnea Syndrome is related to Red Cell Distribution Width and Hematocrit Values

Alkhiary¹

2015

J Sleep Disord Ther

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Background: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by recurrent upper airway collapse during sleep. Recently, some hematological parameters as red cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) have been emerged as inflammatory biomarkers. Limited, controversial data is available on the association between these hematological parameters and the severity of OSAS. Therefore, we aimed to investigate the levels of these parameters in patients with OSAS and its correlation with the severity of OSAS. Methods: The clinical data, polysomnography and laboratory results of complete blood pictures of 116 patients with OSAS were retrospectively collected and statistically analyzed. Results: Obstructive sleep apnea syndrome was associated with increased levels of hematocrit, RDW, MPV, PDW, and platelets count. RDW is positively correlated with Apnea-hypopnea index, oxygen desaturation index, Epworth sleepiness scale, and negatively correlated with minimum oxygen saturation and rapid eye movement sleep. Conclusion: RDW may be a marker for the severity of OSAS. As RDW is included in a complete blood count, it could provide an easy, inexpensive tool for triaging OSAS patients for polysomnography evaluation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Severity of Obstructive Sleep Apnea Syndrome is related to Red Cell Distribution Width and Hematocrit Values

Alkhiary¹

2015

J Sleep Disord Ther

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“…In light of these shared deleterious effects, a number of interesting hypotheses can be posed; we introduce several such hypotheses below. OSA has been linked to local and systemic inflammation, and treatment of sleep apnea with CPAP therapy improves levels of inflammatory markers, including C-reactive peptide (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) (Baessler et al, 2013; Nadeem et al, 2013; Zamarrn et al, 2012). Could inflammation associated with OSA establish a permissive environment for prostatitis or cystitis (inflammatory conditions) that give rise to LUTS?…”

Section: Causes Of Lutsmentioning

confidence: 99%

Links between lower urinary tract symptoms, intermittent hypoxia and diabetes: Causes or cures?

Abler

Vezina

2018

Respiratory Physiology & Neurobiology

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Bothersome lower urinary tract symptoms (LUTS) manifest as urinary frequency, urgency, incontinence and incomplete bladder emptying. Existing treatments ameliorate but do not eliminate most symptoms, leading to financial and personal burdens attributable to sustained medical therapies that may last a lifetime. The purpose of this review is to highlight evidence of causal associations between LUTS and several common comorbidities, including intermittent hypoxia (IH) concomitant with obstructive sleep apnea (OSA), obesity, metabolic syndrome and type 2 diabetes. Links between these conditions, including therapies targeted to co-occurring complications that have demonstrated benefits for LUTS, suggest compelling avenues of research and also underscore critical gaps in understanding the mechanisms underlying urinary dysfunction. These gaps are prominent in the IH field, where an acknowledged link between OSA and LUTS has gone largely uninvestigated. New tools, models, or reappropriation of existing ones, especially rodent models, is required to parse the associations between IH/OSA, LUTS and obesity/diabetes and to elucidate their underlying, and potentially shared, etiologies.

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“…Indeed, breathing disorders during sleep are associated with sleep fragmentation (38) and intermittent hypoxia (10), leading to sympathetic overactivity (5,11) and overproduction of radical oxygen species (42,43). Independently, oxidative stress and sympathetic activity promote an inflammatory state (68,78).…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of a lifestyle intervention program on C-reactive protein: impact of cardiorespiratory fitness in obese adolescents with sleep disturbances

Roche

Isacco

Perret

et al. 2019

American Journal of Physiology-Regulatory, Integrative and Comp

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The objectives of this study were to assess the relationship between inflammation and obstructive sleep apnea (OSA) and determine whether the lifestyle program’s effects on inflammatory markers are associated with changes in anthropometric parameters, cardiorespiratory fitness, sleep duration, and OSA severity in severely obese adolescents. Participants were aged 14.6 (SD 1.2) yr, with a body mass index (BMI) of 40.2 (SD 6.5) kg/m2. Sleep, anthropometric parameters, glucose metabolism, inflammatory profile, and cardiorespiratory fitness [V̇o2peakrelative to body weight (V̇o2peakBW) and fat-free mass (V̇o2peakFFM)] were assessed at admission and at the end of a 9-mo lifestyle intervention program (LIP). Associations between C-reactive protein (CRP) concentrations and BMI, sex, oxygen desaturation index (ODI), sleep fragmentation, total sleep time (TST), and V̇o2peakwere assessed via ANCOVA. Twenty-three subjects completed the study. OSA subjects ( n = 13) exhibited higher CRP concentrations and a trend for higher BMI than non-OSA subjects ( P = 0.09) at admission. After intervention, OSA was normalized in six subjects, and CRP significantly decreased in the OSA group and in the whole population. In both groups, leptin levels significantly decreased, whereas adiponectin concentrations increased. At admission, BMI adjusted for sex, arousal index, ODI, TST, and V̇o2peakBWwas associated with CRP levels (adjusted r2 = 0.32, P < 0.05). The decrease in CRP concentrations postintervention was associated with enhanced V̇o2peakFFMadjusted for sex, weight loss, and changed sleep parameters (adjusted r2 = 0.75, P < 0.05). Despite higher amounts of CRP in OSA subjects, obesity severity outweighs the proinflammatory effects of OSA, short sleep duration, and low cardiorespiratory fitness. However, enhanced cardiorespiratory fitness is associated with the decrease of inflammation after controlling for the same parameters.

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Obstructive Sleep Apnoea Syndrome as a Systemic Low-Grade Inflammatory Disorder

Cited by 3 publications

References 177 publications

The Severity of Obstructive Sleep Apnea Syndrome is related to Red Cell Distribution Width and Hematocrit Values

The Severity of Obstructive Sleep Apnea Syndrome is related to Red Cell Distribution Width and Hematocrit Values

Links between lower urinary tract symptoms, intermittent hypoxia and diabetes: Causes or cures?

Beneficial effects of a lifestyle intervention program on C-reactive protein: impact of cardiorespiratory fitness in obese adolescents with sleep disturbances

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