Obtaining Glycyrrhizic Acid and Its Practically Useful Salts from a Commercial Licorice Root Extract

Кондратенко, Р. М.; Балтина, Л. А.; Михайлова, Л. Р.; Danilov, V. T.; Gabbasov, T. M.; Murinov, Yu. I.; Толстиков, Г. А.

doi:10.1007/s11094-005-0089-9

Cited by 8 publications

(8 citation statements)

References 8 publications

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“…This compound has pharmacological properties such as HIV inhibition, in the food sector, mono-ammonium salt (glycyrram) is a form of sweetener with nutrient enhancement properties. Prednisolone's activity in the treatment of bronchial asthma in children has been restored (Kondratenko et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Glycyrrhizic acid (GA) from Taverniera cuneifolia (Roth) Arn.: In vitro germination and somatic embryogenesis via tissue culture studies

Ghasemi¹,

Namdeo²

2020

ijrps

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Glycyrrhizic acid (GA) is commercially extracted from plant Glycyrrhiza glabra L., while Taverniera cuneifolia (Roth) Arn, licorice of India comprise similar phytochemical constituents but has been least studies on commercial applications. In 21st century, scientist and pharmacognocist explored new biomolecules in several plants which proved to comprise medicinal properties for examination against bacteria and fungi, to circumvent loss of native plants, for better and quantitative extraction using plants of similar properties. GA from the root extracts of plants exhibits promising anti-inflammatory, anti-tumour and anti-germ tube formation protection and other cytotoxic activities. This compound has pharmacological properties such as HIV inhibition, in the food sector, mono-ammonium salt (glycyrram) is a form of sweetener with nutrient enhancement properties. The present study experiments on methods for Development of somatic embryos from root culture and to regenerate plant using root cultures. The observations revealed that, shoot initiation and rate of root growth ranged from 65.4% to 89.3% while plant regeneration from somatic embryos was 82.6% when cultures in 1/4th strength Murashige and Skoog (MS) medium by sucrose 2% used as a supplement. The study illustrates that proliferative germination of seeds in respective media and also suggested that T. cuneifolia could be used as substitute of G. Glabra used as an systematic methodology and plants are mass-produced from a single mother plant.

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Section: Introductionmentioning

confidence: 99%

Glycyrrhizic acid (GA) from Taverniera cuneifolia (Roth) Arn.: In vitro germination and somatic embryogenesis via tissue culture studies

Ghasemi¹,

Namdeo²

2020

ijrps

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“…(urals licorice) and Abrus precatorius L. (precatory bean;Windholz 1983;Zapesochnaya et al 1994;Zore et al 2007;Karwasara et al 2010). As an active principal in these plants, GA exhibits anti-inflammatory, anti-ulcerous, antidotal, antiallergic, anticancer and immuno-modulating activities (Kondratenko et al 2005). GA, being capable of inhibiting HIV, is regularly involved in the treatment of HIV patients.…”

Section: Introductionmentioning

confidence: 99%

“…Its mono-ammonium salt (glycyrram) is used as a sweetener (300 times sweeter than sugar) and is a taste-improving nutrient additive in the food industry. It is an antiviral agent, valuable anti-inflammatory and anti-allergic drug, capable of replacing prednisolone in the treatment of bronchial asthma, especially in children (Kondratenko et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Somatic embryogenesis, regeneration and in vitro production of glycyrrhizic acid from root cultures of Taverniera cuneifolia (Roth) Arn.

Awad

Shirke

Mukherjee

et al. 2011

In Vitro Cell.Dev.Biol.-Plant

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Taverniera cuneifolia (Roth) Arn. or Indian licorice is considered to be a substitute for Glycyrrhiza glabra L. owing to an equivalent content of glycyrrhizic acid (GA). GA recognized as the main active ingredient of T. cuneifolia, GA imparts several medicinal properties to these plants. However, research on this plant is scanty with no published record on tissue culture studies. Present study demonstrates a method for (1) induction and successful development of somatic embryos from the root culture, (2) regeneration of plants, and (3) GA production by root cultures of T. cuneifolia. Shoot initiation frequency of cultured roots ranged from 52.57% to 97.71%. Plant regeneration frequency (germination) from somatic embryos was 88.66% in 1/4-strength Murashige and Skoog (MS) medium supplemented with 2% sucrose, as against 68% in half 1/2-strength MS containing 2% sucrose. Glycyrrhizic acid of 1.32 mg/gm of dry weight was obtained in fullstrength MS medium supplemented with 3% sucrose, through high-performance thin layer chromatography analysis with standard GA in root cultures. The present study provides an efficient method for the mass production of plants from a single mother plant as well as the potential root culture system to study the GA production pathways in T. cuneifolia.

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“…The herb grows wild over wide areas. The major bioactive ingredients in licorice include glycyrrhizic acid (GA) and liquiritin (LQ) that have several important pharmacological activities including anti-viral, anti-inflammatory, anti-oxidant, anti-ulcer, anti-cancer and anti-HIV [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Concentration of licorice aqueous solutions using nanofiltration and reverse osmosis membranes

Sohrabi

Madaeni

Khosravi

et al. 2010

Separation and Purification Technology

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Obtaining Glycyrrhizic Acid and Its Practically Useful Salts from a Commercial Licorice Root Extract

Cited by 8 publications

References 8 publications

Glycyrrhizic acid (GA) from Taverniera cuneifolia (Roth) Arn.: In vitro germination and somatic embryogenesis via tissue culture studies

Glycyrrhizic acid (GA) from Taverniera cuneifolia (Roth) Arn.: In vitro germination and somatic embryogenesis via tissue culture studies

Somatic embryogenesis, regeneration and in vitro production of glycyrrhizic acid from root cultures of Taverniera cuneifolia (Roth) Arn.

Concentration of licorice aqueous solutions using nanofiltration and reverse osmosis membranes

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