Obtaining of Morphine-Bsa Conjugate for Using in Elisa as an Antigen for Sorbsion

O’G’Li, Eshboev Farkhod Bakir; Gaynatovna, Yusupova Elvira; Aliksandrovna, Piyakina Galina; Сасмаков, С. А.; Sadikovna, Azimova Shakhnoz

doi:10.29013/esr-19-9.10-16-20

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2021

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“…The basis for the development of this type of ELISA test kits are hapten-protein conjugate absorbed immunosorbents. Because hapten-protein conjugates provide the specificity and sensitivity of the ELISA test kits [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The Use of Different Proteins as a Carrier Protein to Obtaining Morphine-Protein Conjugates for ELISA Diagnosis of Drug Addicts

Eshboev

Yusupova

Piyakina

et al. 2021

JPRI

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Drug addiction is one of the biggest problems of medicine because diagnosis and treatment of drug addiction are difficult compared with some other socially significant diseases. In this study, synthesis and evaluation of four carrier protein-morphine conjugates were experimented. These conjugates were evaluated based on ELISA; soybean protein-based conjugate was selected for further analysis. The total soybean protein was isolated from the local soybean variety and; it was fractioned by the gel-filtration method and their amino acids compositions were studied. After that, the ELISA drug addicts were conducted based on soybean protein-morphine conjugates synthesized with soybean protein fractions. The high molecular weight soybean protein- morphine conjugate showed the highest quality.

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Section: Introductionmentioning

confidence: 99%