Objective: The aim of this study was to evaluate the comprehension of dental practitioners regarding the complexities encountered by patients undergoing prosthetic rehabilitation following oral cancer surgery. Methods: This research employed a descriptive-quantitative approach. The study population comprised 37 dentists representing various specialized fields located in Montes Claros, Minas Gerais, Brazil. Data were gathered through an online semi-structured questionnaire designed to elicit insights into the knowledge and perceptions of these professionals pertaining to prosthetic rehabilitation in post-oral cancer surgery patients. Results: The results indicated that 75.7% of the participants reported a high level of patient satisfaction with prosthetic treatment. Notable improvements were observed in mastication (94.6%), respiration (35.1%), oral muscle function (48.6%), phonation (56.8%), overall health (59.5%), self-esteem (100.0%), and occlusion (62.2%). Furthermore, the presence of a multidisciplinary healthcare team for managing these patients was noted. Conclusion: In conclusion, it can be inferred that dentists possess a comprehensive understanding of the diverse challenges confronted by patients in the context of prosthetic rehabilitation following oral oncologic surgery. Additionally, the study underscores the pivotal role of prosthetic rehabilitation in enhancing patients’ functional abilities, aesthetics, and overall comfort.