OC-005 Preoperative vs. postoperative radiotherapy in treatment of oral cavity cancer - The ARTSCAN 2 study

Carlwig, Kristin; Zackrisson, Björn; Nilsson, Peter; Kjellén, Elisabeth; Brun, Eva; Söderkvist, Karin; Reizenstein, Johan; Kristiansson, Stefan; Gebre‐Medhin, Maria; Sjövall, Johanna; Wennerberg, Johan

doi:10.1016/s0167-8140(19)30171-9

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“…The ARTSCAN II is a Swedish multicenter randomized controlled study aimed to compare the efficiency of preoperative accelerated radiotherapy followed by surgery with surgery followed by postoperative radiotherapy, including chemotherapy for high risk resectable tumors in the oral cavity. Preliminary data with respect to loco‐regional control and survival have been presented 14 . Patients with T1‐T4 and/or N0‐3 tumors were included.…”

Section: Methodsmentioning

confidence: 99%

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A longitudinal study of the Swedish MD Anderson Dysphagia Inventory in patients with oral cancer

Tuomi

Fransson

Wennerberg

et al. 2020

Laryngoscope Investig Oto

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Objective: The aim of this study was to investigate whether the Swedish MD. Anderson Dysphagia Inventory (MDADI) is able to detect changes in dysphagia symptoms over time for patients with head and neck cancer (HNC). Methods: One hundred and forty-two patients with resectable tumors of the oral cavity were included prior to treatment. The patients filled out the MDADI, European Organization for Research and Treatment of Cancer Quality of Life questionnaire Core 30 (EORTC QLQ-C30) and the HNC module (H&N35) at baseline and at least one follow-up at 6 and/or 12 months after oncologic treatment. A control group without dysphagia (n = 115) was included. Results: Self-perceived swallowing function decreased in all domains at 6 months, and improved between 6 and 12 months. The changes were similar to the changes of the EORTC domains, indicating a sensitivity to change. However, even if improvements were seen at 12 months, the values were still inferior compared to baseline values, and the values of a control group without dysphagia. Convergent validity was found with values of the MDADI and EORTC domains producing similar results, and moderate correlations as hypothesized. Patients with moderate-severe dysphagia according to the MDADI (<60 points) demonstrated inferior values of the EORTC domains compared to patients with scores above 60 points. Conclusion: The Swedish MDADI was found to be sensitive to change, and showed convergent results when compared to other established instruments. The threshold value for the MDADI (<60 points) indicating moderate-severe dysphagia may be a valuable addition in the clinical use.

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Section: Methodsmentioning

confidence: 99%

“…Preliminary data with respect to loco-regional control and survival have been presented. 14 Patients with T1-T4 and/or N0-3 tumors were included. In total, 250 patients were included in the study of which six (n = 6) patients withdrew their consent leaving 244 patients eligible for the ARTSCAN II-study.…”

Section: Participantsmentioning

confidence: 99%