OC-018 Obesity and type 2 diabetes are predominant risk factors underlying previously undetected cirrhosis in the general population

Harman, D. J.; Wilkes, EA; James, MW; Ryder, SD; Card, Timothy; Aithal, GP; Guha, IN

doi:10.1136/gutjnl-2015-309861.18

Cited by 2 publications

(2 citation statements)

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“…(21,29) Therefore, studies reporting high incidence rates of liver disease progression in NAFLD/NASH had probably unmeasured confounding liver-related risk factors, including alcohol use. (23)(24)(25)(26)(27) For example, alcohol use disorders interacted with all components of the metabolic syndrome in this cohort, including obesity; therefore unreported alcohol use may have contributed to liver disease progression in patients without any risk factor diagnosed. Smoking was a good example of unmeasured confounding.…”

Section: Discussionmentioning

confidence: 88%

Burden of liver disease progression in hospitalized patients with type 2 diabetes mellitus

Parlati

Martinino

Pereira

et al. 2022

Journal of Hepatology

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Section: Discussionmentioning

confidence: 88%

Burden of liver disease progression in hospitalized patients with type 2 diabetes mellitus

Parlati

Martinino

Pereira

et al. 2022

Journal of Hepatology

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“…In Nottingham, the Scarred Liver Project (SLP) established a commissioned pathway in which the General Practitioner (GP) identifies patients for screening for CLD based on risk factors. Initial pilot studies in 2013 focused on risk factors for CLD and the pathway is applicable to both metabolic and alcohol related disease etiologies (11,16). GPs having direct access to FibroScan R is an integral feature.…”

Section: Early Detection Of Liver Disease In the Ukmentioning

confidence: 99%

Health Technology Adoption in Liver Disease: Innovative Use of Data Science Solutions for Early Disease Detection

Bennett

Purssell

Street

et al. 2022

Front. Digit. Health

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Chronic liver disease (CLD) is an ignored epidemic. Premature mortality is considerable and in the United Kingdom (UK) liver disease is in the top three for inequitable healthcare alongside heart and respiratory disease. Fifty percentage of patients with CLD are first diagnosed with cirrhosis after an emergency presentation translating to poorer patient outcomes. Traditional models of care have been based in secondary care when the need is at community level. Investigating patients for disease based on their risk factors at a population level in the community will identify its presence early when there is potential reversibility. Innovation is needed in three broad areas to improve clinical care in this area: better access to diagnostics within the community, integrating diagnostics across primary and secondary care and utilizing digital healthcare to enhance patient care. In this article, we describe how the Integrated Diagnostics for Early Detection of Liver Disease (ID-LIVER) project, funded by UK Research and Innovation, is developing solutions in Greater Manchester to approach the issue of diagnosis of liver disease at a population level. The ambition is to build on innovative pathways previously established in Nottingham by bringing together NHS organizations, academic partners and commercial organizations. The motivation is to co-create and implement a commercial solution that integrates multimodal diagnostics via cutting edge data science to drive growth and disrupt the currently inadequate model. The ambitious vision is for this to be widely adopted for early diagnosis and stratification of liver disease at a population level within the NHS.

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OC-018 Obesity and type 2 diabetes are predominant risk factors underlying previously undetected cirrhosis in the general population

Cited by 2 publications

References 0 publications

Burden of liver disease progression in hospitalized patients with type 2 diabetes mellitus

Burden of liver disease progression in hospitalized patients with type 2 diabetes mellitus

Health Technology Adoption in Liver Disease: Innovative Use of Data Science Solutions for Early Disease Detection

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