Occlusion-amblyopia following high dose oral levodopa combined with part time patching

Kothari, Mihir

doi:10.4103/0301-4738.109516

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…[ 65 ] The drug is bitter in taste and therefore advised to use it with a protein drink. [ 66 67 ] Overall, levodopa has been shown to be well tolerated in children. [ 47 ] Leguire et al .…”

Section: Pharmacological Therapymentioning

confidence: 99%

Pharmacological therapy for amblyopia

Singh

Nagpal

Mittal

et al. 2017

Taiwan J Ophthalmol

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Amblyopia is the most common cause of preventable blindness in children and young adults. Most of the amblyopic visual loss is reversible if detected and treated at appropriate time. It affects 1.0 to 5.0% of the general population. Various treatment modalities have been tried like refractive correction, patching (both full time and part time), penalization and pharmacological therapy. Refractive correction alone improves visual acuity in one third of patients with anisometropic amblyopia. Various drugs have also been tried of which carbidopa & levodopa have been popular. Most of these agents are still in experimental stage, though levodopa-carbidopa combination therapy has been widely studied in human amblyopes with good outcomes. Levodopa therapy may be considered in cases with residual amblyopia, although occlusion therapy remains the initial treatment choice. Regression of effect after stoppage of therapy remains a concern. Further studies are therefore needed to evaluate the full efficacy and side effect profile of these agents.

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Section: Pharmacological Therapymentioning

confidence: 99%

Pharmacological therapy for amblyopia

Singh

Nagpal

Mittal

et al. 2017

Taiwan J Ophthalmol

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“…34 Bazı çalışmalarda ise kapama tedavisine ilaveten uygulandığında daha hızlı ve daha iyi sonuçlar elde edildiği görülmüştür. 35 En önemli avantajı olarak ambliyopide geri dönüşüm meydana getirmediği belirtilmiştir. 33 Son zamanlarda özellikle 9 yaş üzerinde çok çalışılan ve uygulanılan bir tedavi yöntemi ise algısal öğrenme ya da daha diğer bir ismiyle nörovizyon tedavisidir.…”

Section: Güncel Tedaviunclassified

Amblyopia and Current Treatment Approaches

Çelik¹

2017

jcp

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Ambliyopi, çocukluğun erken dönemlerinde sağlıklı görme gelişiminin sağlanamaması sonucu ortaya çıkan görme keskinliğinde azalma durumudur. Refraksiyon kusuru, şaşılık, anatomik ya da konjenital engeller gibi ambliyopiye neden olan risk faktörlerinin ortadan kaldırılması görme gelişiminin arttırılmasını sağlar. Günümüzde erişkinlerde de tedavinin mümkün olduğunu savunan çalışmalar olsa da genel kabul gören görüş ambliyopinin erken tedavi edilmediği takdirde, geri döndürülemez ve yaşam boyu etkisini gösteren bir görme azlığına sebep olmasıdır . Bu derlemede, aileler ve klinisyenler açısından son derece önemli bir durum olan ambliyopinin nedenleri ve günümüzdeki tanı ve tedavi yaklaşımları ele alınmaya çalışılmıştır.

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“…Several reports indicate that Levodopa either alone or in combination with occlusion, can be useful to improve vision in the amblyopic eye [1,[7][8][9][10][11] 0.5 to 2mg/kg/dose thrice a day is considered a safe and effective dose. When combined with 25% Carbidopa, conversion of Levodopa to dopamine is prevented in the peripheral circulation, which reduces the systemic side effects of levodopa.…”

mentioning

confidence: 99%

Levodopa as Treatment for Adults with Amblyopia

Bogdănici¹,

Bogdanici²,

Moraru³

et al. 2017

Rev. Chim.

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Levodopa is a medication used in treatment for Parkinson�s disease, which is associated with low levels of a chemical called dopamine in the brain. Levodopa is turned into dopamine in the body and therefore increases levels of this chemical. Levodopa was used as a treatment of amblyopia alone or in combination with classical treatment of occlusion. Visual acuity is improved after treatment with oral Levodopa. When is used as an adjunct to the occlusion therapy, Levodopa can be associated with long-term improvement in the vision, and may have also better compliance for patching. Levodopa stimulates the brain plasticity in adult age and can be used in treatment for amblyopia. Patients have also an increase of the visual acuity after orthoptic treatment for amblyopia and when Levodopa is administered, the vision increases much more. Contrary to the classical conception, according to which amblyopia cannot be treated after 10-12 years of age and it is untreatable in adults, studies about treatment with Levodopa in amblyopic eyes, may allow the improvement of the visual acuity in adults, as well.

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Occlusion-amblyopia following high dose oral levodopa combined with part time patching

Cited by 4 publications

References 11 publications

Pharmacological therapy for amblyopia

Pharmacological therapy for amblyopia

Amblyopia and Current Treatment Approaches

Levodopa as Treatment for Adults with Amblyopia

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