Occlusion of Choriocapillaris in Primary Nonfamilial Amyloidosis

Tso, Mark O.M.; Bettman, Jerome W.

doi:10.1001/archopht.1971.01000010283008

Cited by 38 publications

(14 citation statements)

References 3 publications

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“…Amyloid deposits in the choroid, especially in the choriocapillaris, were reported in a histopathological study by Ts’o and Bettman 7. They documented the occlusion of the choriocapillaris by amyloid deposits in a patient with primary systemic amyloidosis.…”

Section: Discussionmentioning

confidence: 92%

Retinal and choroidal circulation determined by optical coherence tomography angiography in patient with amyloidosis

et al. 2019

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A 43-year-old woman who was diagnosed with the cryopyrine-associated periodic syndrome (CAPS) with severe renal failure and heart failure due to amyloid accumulation was examined by swept source optical cohernce tomography (OCT) (SS-OCT; DRI-OCT, Topcon, Tokyo, Japan) and optical coherence tomography angiography (OCTA) (RTVue XR Avanti, Optovue, Fremont, CA). Her best-corrected visual acuity was 20/40 OD and 20/25 OS. A hyporeflective band of about 100 µm thickness was seen just inferior to the retinal pigment epithelium in the cross-sectional SS-OCT images, but the deeper choroidal structures were clearly visible. In the OCTA images, the density of the retinal capillaries in the superficial and deep capillary plexus slabs were reduced, and no signals of the choroidal capillary slab was detected after removing the projection artefacts. The accumulation of amyloid can cause a reduction of both the retinal and choroidal capillary circulations although the circulation in the larger vessels are preserved.

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Section: Discussionmentioning

confidence: 92%

Retinal and choroidal circulation determined by optical coherence tomography angiography in patient with amyloidosis

et al. 2019

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“…Choroidal involvement in patients with nonfamilial amyloidosis (NFA) has been rarely described [5, 6]. …”

Section: Introductionmentioning

confidence: 99%

Indocyanine green angiography findings in patients with nonfamilial amyloidosis

Attia

Kahloun

Mbarek

et al. 2012

J Ophthal Inflamm Infect

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PurposeThe purpose of this study is to assess indocyanine green angiographic findings in patients with nonfamilial amyloidosis.MethodsThe method used was a prospective study including seven patients (14 eyes) with nonfamilial amyloidosis. All patients underwent detailed ophthalmic clinical examination, fundus photography, and indocyanine green angiography (ICGA). Fluorescein angiography (FA) was performed in four patients.ResultsOf the seven patients, four (57.1 %) were male. Mean age was 49.5 years. Six patients had renal amyloidosis and one patient had systemic amyloidosis. Mean best-corrected visual acuity was 20/25. Fundus and FA findings included cotton-wool spots (28.5 %), retinal hemorrhages (14.3 %), retinal pigment epithelial changes (21.4 %), serous retinal detachment (7.1 %), optic disk edema or staining (7.1 %), area of peripheral retinal capillary non-perfusion (7.1 %), disseminated peripheral punctiform hyperfluorescence (21.4 %), and subretinal pooling (7.1 %). Fundus examination results were unremarkable in eight eyes (57.1 %). ICGA showed abnormal findings in all eyes. These included diffuse or focal/multifocal choroidal vascular staining appearing at the late phase and prevailing in peripheral fundus (100 %), hyperfluorescent fleecy lesions appearing at the late phase and also prevailing in peripheral fundus (28.5 %), hypofluoresent areas of variable sizes (85.7 %), and pinpoints (71.4 %).ConclusionsOur results show that a subclinical, fairly typical choroidal involvement, detectable only by ICGA, is common in patients with nonfamilial amyloidosis. ICGA may be useful in better understanding the pathogenesis of amyloidosis choroidopathy and in establishing a diagnosis of amyloidosis in atypical or incomplete clinical presentations.

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“…The retinal vascular changes of familial primary amyloidosis were described by a few investigators, and the pathogenesis of vitre ous opacities, the most characteristic feature in this disease, was attributed to the disor der of retinal vessels by histological ex amination [Paton and Duke, 1966;Wong and McFarlin, 1967;Tso and Bettman, 1971;Inomata et al, 1976].…”

Section: Introductionmentioning

confidence: 99%