Occlusion of the internal jugular vein in differentiated thyroid carcinoma: Causes and diagnosis

Hartl, Dana M.; Zafereo, Mark; Kowalski, Luiz Paulo; Randolph, Gregory W.; Olsen, Kerry D.; Fernández-Álvarez, Verónica; Nixon, Iain J.; Shaha, Ashok R.; Angelos, Peter; Shah, Jatin P.; Ferlito, Alfio

doi:10.1016/j.ejso.2021.02.021

Cited by 4 publications

(8 citation statements)

References 56 publications

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“…Total thyroidectomy, neck dissection and resection of any involved organ accompanied by adjuvant therapy is considered the treatment of choice in locally advanced well-differentiated tumors. Intraluminal extension is not a contraindication for aggressive surgical treatment in differentiated thyroid cancers due to the relatively good prognosis of PTC [ 8 , 9 ]. In our case the tumor was not attached to the vascular wall and was surrounded by a fibrous capsule which made its removal and vascular repair feasible.…”

Section: Discussionmentioning

confidence: 99%

Intraluminal extension of papillary thyroid carcinoma into the Internal Jugular Vein; a case report

Jafari,

Akerdi,

Fard

et al. 2024

BMC Endocr Disord

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Background Papillary thyroid carcinoma (PTC), being the most common thyroid malignancy, is a slow-growing tumor and is usually limited to the thyroid. Extra thyroid extension is uncommon; besides, invasion to the vasculature seems to be extremely rare and usually indicates aggressive nature of the disease. Case presentation We present a case of a 40-year-old lady who referred with a palpable neck mass a month after total thyroidectomy which its histopathologic examination revealed follicular variant of PTC; the same variant as prior thyroidectomy. Preoperative ultrasonography failed to comment on the intravascular component of the mass. Surgical procedure confirmed a mass attaching and infiltrating to the internal jugular vein, which turned out to be persistent disease. Conclusions Awareness of this entity is important for surgeons, oncologists and radiologist as it can influence patient management.

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Section: Discussionmentioning

confidence: 99%

Intraluminal extension of papillary thyroid carcinoma into the Internal Jugular Vein; a case report

Jafari,

Akerdi,

Fard

et al. 2024

BMC Endocr Disord

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“…11 Papillary thyroid carcinoma has demonstrated intravascular extension and tumor thrombus formation within the IJV, without direct vein invasion. [11][12][13] Similarly, tumor thrombus of the IVC via intravascular extension of the primary tumor is a well-described occurrence in RCC; however, direct tumor thrombus of the IJV from metastatic RCC is extremely rare. 8,[14][15][16] Given the propensity for RCC to demonstrate intravascular spread, preoperative imaging is imperative for evaluation of vascular extension prior to surgery.…”

Section: Discussionmentioning

confidence: 99%

“…This report describes a unique occurrence of intravascular tumor thrombosis of the IJV in a patient with metastatic RCC to the thyroid gland. Direct vascular invasion by both primary and metastatic tumors of the thyroid gland has been described in the literature 11 . Papillary thyroid carcinoma has demonstrated intravascular extension and tumor thrombus formation within the IJV, without direct vein invasion 11–13 .…”

Section: Discussionmentioning

confidence: 99%

“…Direct vascular invasion by both primary and metastatic tumors of the thyroid gland has been described in the literature 11 . Papillary thyroid carcinoma has demonstrated intravascular extension and tumor thrombus formation within the IJV, without direct vein invasion 11–13 . Similarly, tumor thrombus of the IVC via intravascular extension of the primary tumor is a well‐described occurrence in RCC; however, direct tumor thrombus of the IJV from metastatic RCC is extremely rare 8,14–16 …”

Section: Discussionmentioning

confidence: 99%

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Metastatic renal cell carcinoma to the thyroid with cervicothoracic venous tumor thrombosis

et al. 2023

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Introduction Metastatic renal cell carcinoma (RCC) represents 25%–42% of metastatic thyroid malignancies. Propensity for RCC to demonstrate intravascular extension to the inferior vena cava is well documented. We present an analogous phenomenon of intravascular extension to the internal jugular vein (IJV) from thyroid gland metastasis. Methods A 69‐year‐old male presented with metastatic RCC of the right thyroid lobe. Imaging demonstrated tumor thrombosis of the ipsilateral IJV, extending inferiorly to the junction of the brachiocephalic, subclavian, and internal jugular veins within the mediastinum. Results Surgical excision required control of both the IJV in the neck and mediastinal venous great vessels via sternotomy, prior to subtotal thyroidectomy and venotomy for en bloc resection. Conclusion This case report describes metastatic RCC to the thyroid gland with cervicothoracic venous tumor thrombosis successfully treated with subtotal thyroidectomy, sternotomy for venotomy and tumor thrombectomy, and preservation of IJV conduit.

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“…Thyroid cancer is a well-known cause of jugular vein thrombosis and despite aggressive multimodal treatment, patients with thyroid cancer that caused IJV thrombosis typically have a poor prognosis, with early lung metastases and high mortality. 2 The occurrence of IJV thrombosis in head and neck Squamous Cell Carcinoma (SCC) that has directly invaded the IJV is extremely rare. 3 …”

Section: Introductionmentioning

confidence: 99%

Internal jugular vein thrombosis caused by invasive pharyngeal cancer: a case report and literature review

Tudor,

Košec,

Pegan

2024

Brazilian Journal of Otorhinolaryngology

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Occlusion of the internal jugular vein in differentiated thyroid carcinoma: Causes and diagnosis

Cited by 4 publications

References 56 publications

Intraluminal extension of papillary thyroid carcinoma into the Internal Jugular Vein; a case report

Intraluminal extension of papillary thyroid carcinoma into the Internal Jugular Vein; a case report

Metastatic renal cell carcinoma to the thyroid with cervicothoracic venous tumor thrombosis

Internal jugular vein thrombosis caused by invasive pharyngeal cancer: a case report and literature review

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