Abstract.In this brief review, we have examined some clinical conditions that result to be associated to an altered hemorhe-6 ological profile and at times accompanied by skin ulcers. This skin condition may be observed in patients with the following 7 condtions, such as primary polycythemic hyperviscosity (polycythemia, thrombocytemia) treated with hydroxyurea, primary 8 plasma hyperviscosity (multiple myeloma, cryoglobulinemia, cryofibrinogenemia, dysfibrinogenemia, and connective tissue 9 diseases), primary sclerocythemic hyperviscosity (hereditary spherocytosis, thalassemia, and sickle cell disease). In addition,
10it may be present in patients with secondary hyperviscosity conditions such as diabetes mellitus, arterial hypertension, critical 11 limb ischemia and chronic venous insufficiency.