2015
DOI: 10.1111/liv.12802
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Occult cirrhosis diagnosed by transient elastography is a frequent and under‐monitored clinical entity

Abstract: Occult cirrhosis is a frequent and under-monitored clinical entity associated with short-term risk of outcomes. TE may help early diagnosis, prompt initiation of surveillance and specific therapy for an otherwise unrecognized condition.

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Cited by 12 publications
(7 citation statements)
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“…In our large combined cohort of 1092 HIV-infected patients, OcC was found in 2.7% of cases, a prevalence similar to that reported in other populations [7,9]. Although seemingly comprising only a small proportion of patients at baseline TE, the prevalence of OcC increased to 3.9% during the follow-up period, with an annual incidence rate of 10 per 1000 PY.…”
Section: Discussionsupporting
confidence: 85%
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“…In our large combined cohort of 1092 HIV-infected patients, OcC was found in 2.7% of cases, a prevalence similar to that reported in other populations [7,9]. Although seemingly comprising only a small proportion of patients at baseline TE, the prevalence of OcC increased to 3.9% during the follow-up period, with an annual incidence rate of 10 per 1000 PY.…”
Section: Discussionsupporting
confidence: 85%
“…Given the lack of any clinical sign, patients at the preclinical stage of compensated cirrhosis represent a diagnostic challenge for clinicians, and often remain undiagnosed. The diagnosis of OcC based on LSM and the absence of clinical signs has previously been shown, in different patient populations, to be an indicator of poor prognosis [7,9]. Individuals living with HIV are known to be at increased risk of liver cirrhosis and ESLD [1].…”
Section: Discussionmentioning
confidence: 99%
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“…To us, liver biopsy is not a feasible screening tool and may pose a barrier to identification of patients with advanced liver fibrosis in urgent need of treatment. In our centre, a screening strategy using transient elastography revealed occult cirrhosis without any clinical sign in 12% of all patients with chronic liver disease and in 37% of all cirrhotic patients (7). Importantly, only 36% of patients with occult cirrhosis receive the recommended surveillance for hepatocellular carcinoma and esophageal varices.…”
mentioning
confidence: 88%
“…35 Transient elastography has been shown to help diagnose clinically occult cirrhosis, thus leading to early therapy and surveillance. 36 In particular, TE has been shown to be able to identify subclinical cirrhosis in patients with chronic hepatitis B who are at risk for hepatocellular carcinoma and would thus benefit from screening. 37 Elastography has been shown to be a reliable tool for assessing the degree of fibrosis.…”
Section: Elastography For Assessing Fibrosis and Cirrhosismentioning
confidence: 99%