Occult hepatitis B in mexican patients with HIV, an analysis using nested polymerase chain reaction

Torres-Baranda, Rodrigo; Bastidas-Ramírez, Blanca Estela; Maldonado-González, Montserrat; Sánchez-Orozco, Laura V.; Vázquez-Vals, Eduardo; Rodríguez-Noriega, Eduardo; Panduro, Arturo

doi:10.1016/s1665-2681(19)32037-x

Cited by 30 publications

(25 citation statements)

References 33 publications

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“…A wide range of HBsAg (0.7–37.3%) and anti‐HBc prevalence (13.9–48.2%) was found, as well as differential rates of infection. Furthermore, HBV‐DNA testing revealed 6.8% (8/117) of occult B infection cases, which was consistent with data reported in blood donors, natives, and HIV‐infected Mexican patients . On the other hand, the fluctuations in HBV markers that apparently lead to a discordant profile may be related to an immunogenetic response to suppress the virus favoring a rapid decline of HBsAg .…”

Section: Discussionsupporting

confidence: 88%

“…Furthermore, HBV-DNA testing revealed 6.8% (8/117) of occult B infection cases, which was consistent with data reported in blood donors, natives, and HIV-infected Mexican patients. 21,22,29 On the other hand, the fluctuations in HBV markers that apparently lead to a discordant profile may be related to an immunogenetic response to suppress the virus favoring a rapid decline of HBsAg. 30 This feature has been considered as an adaptableness of the native population to the endemic HBV genotypes H or F. 20 Moreover, it has been suggested that the populations of Latin America exposed to these endemic genotypes may be less sensitive to testing with the standard HBV immunoassays originally designed for genotypes A and D. 28 Therefore, serial testing with HBsAg, anti-HBc, and HBV-DNA markers has been recommended to discard HBV infection.…”

Section: Hbv Risk Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…On the other hand, Mexican patients with asymptomatic chronic B infection and occult B hepatitis infection may frequently course with low viremia and fluctuations of HBV markers. 13,[21][22][23][24] Thus, a different diagnostic strategy than testing only with HBsAg is required to avoid omitting HBV infection in the health care setting. Given the social, virological, clinical-diagnostic features mentioned above, the magnitude of HBV infection in different risk groups may be underestimated.…”

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confidence: 99%

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High prevalence of HBV infection, detection of subgenotypes F1b, A2, and D4, and differential risk factors among Mexican risk populations with low socioeconomic status

José-Ábrego

Panduro

Fierro

et al. 2017

Journal of Medical Virology

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Hepatitis B virus (HBV) infection may be underestimated among high-risk individuals in regions of low HBs antigenemia. This study aimed to assess HBV serological markers, genotypes, and risk factors in Mexican patients with risk of HBV infection and low socioeconomic status. Demographics, clinical, and risk factor data were collected in patients with HIV (n = 289), HCV (n = 243), deferred blood donors (D-BD) (n = 83), and two native populations, Mixtecos (n = 57) and Purepechas (n = 44). HBV infection was assessed by HBsAg, anti-HBc, and HBV-DNA testing. Overall, patients had low education and very-low income. Totally, HBsAg prevalence was 16.5% (113/684) ranging from 0.7% (HCV) to 37.3% (D-BD), while anti-HBc was 30.2% (207/684). Among 52 sequences, genotypes H (n = 34, 65.4%), G (n = 4, 7.7%), subgenotypes F1b (n = 7, 13.5%), A2 (n = 6, 11.5%), and D4 (n = 1, 1.9%) were detected. Surgeries, sexual promiscuity, and blood transfusions had a differential pattern of distribution. In HCV patients, single (OR = 5.84, 95%Cl 1.91-17.80, P = 0.002), MSM (OR = 4.80, 95%Cl 0.75-30.56, P = 0.097), and IDU (OR = 2.93, 95%CI 1.058-8.09, P = 0.039) were predictors for HBV infection. While IDU (OR = 2.68, 95%CI 1.08-6.61, P = 0.033) and MSM (OR = 2.64, 95%CI 1.39-5.04, P = 0.003) were predictors in HIV patients. In this group, MSM was associated with HBsAg positivity (OR = 3.45, 95%CI 1.48-8.07, P = 0.004) and IDU with anti-HBc positivity (OR = 5.12, 95%CI 2.05-12.77, P < 0.001). In conclusion, testing with a combined approach of three different HBV markers, a high prevalence of HBV infection, a differential distribution of HBV genotypes, including subgenotypes F1b, A2, and D4, as well as risk factors in low-income Mexican risk groups were detected.

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Section: Discussionsupporting

confidence: 88%

Section: Hbv Risk Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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High prevalence of HBV infection, detection of subgenotypes F1b, A2, and D4, and differential risk factors among Mexican risk populations with low socioeconomic status

José-Ábrego

Panduro

Fierro

et al. 2017

Journal of Medical Virology

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show abstract

“…In fact, the published prevalence ranges from 0% to 89% [73,74], with a considerable number of other studies reporting results between those two extremes [75][76][77][78][79][80][81][82][83] ( Table 2). The great difference in sensitivity and specificity of the assays used in these various studies has already been denounced in a previous review [84].…”

Section: Prevalencementioning

confidence: 99%