Occult hepatitis B virus among chronic liver disease patients in Yemen

Thabit, AM; Ka, Al-Moyed; Al-Balushi,; Hasson, Sidgi S.; Sallam, TA

doi:10.1016/s2222-1808(12)60002-4

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…Occult HBV have been detected in 7.2% of adult patients in Ibadan, Nigeria but none in the control group of the study [24]. Thabit et al [21] reported 50% of occult HBV among HBcAb positive individuals in Yemen.…”

Section: E M Mbaawuaga Et Almentioning

confidence: 71%

“…The prevailing situation where blood donors in most hospitals and laboratories are only screened for HBsAg, HIV, HCV and other factors but not for HBcAb in HBsAg negative donors means overlooking potential sources of HBV infection, the occult HBV individuals. This puts those undergoing immunosuppressive therapy and the immuno-compromised at great risk of infection [21]. Occult HBV have been detected in 7.2% of adult patients in Ibadan, Nigeria but none in the control group of the study [24].…”

Section: E M Mbaawuaga Et Almentioning

confidence: 91%

“…Occult HBV is used to explain the presence of HBV viraemia without HBsAg in the presence or absence of antibodies and can be identified by a molecular assay [21]. All forms of occult HBV could be infectious in immune-compromised individuals; but detection of HBVDNA in individuals with only HBcAb was associated with infectivity in both immuno-compromised and immuno-competent individuals, especially in blood transfusion [22].…”

Section: E M Mbaawuaga Et Almentioning

confidence: 99%

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Hepatitis B Virus (HBV) Serological Patterns in Benue State, Nigeria

Mbaawuaga¹,

Iroegbu²,

Ike³

2014

OJMM

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A total of 1535 randomly collected blood specimens from different groups of consenting subjects in Benue State, were screened by ELISA for Hepatitis B surface antigen (HBsAg), hepatitis B surface antibodies (HBsAb), hepatitis B core antibodies (HBcAb), hepatitis Be antigen (HBeAg) and Hepatitis B core IgM antibodies (HBcIgM). The pattern of occurrence of these HBV markers in each blood sample was used to determine individuals with current, acute or chronic infection histories. Of the 1535 sampled individuals, 1319 (85.9%) showed a serological evidence of exposure to HBV infection, some through natural infection (22.7%) and others (13.0%) through vaccination; 12% of the exposed were inferred to be currently infected and 91.2% chronically infected. Hepatitis delta virus (HDV) antigen was also detected in 2.7% of the HBsAg positive individuals; and was encountered more (6.7%) in those with acute hepatitis than those with chronic disease. Thus, there are apparently healthy persons with acute and chronic HBV and HDV infection who may serve as source of infection to others. This calls for a government organized Hepatitis Programme to treat cases of acute and chronic hepatitis and roll out strategy for preventing the spread of HBV infections.

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Section: E M Mbaawuaga Et Almentioning

confidence: 71%

Section: E M Mbaawuaga Et Almentioning

confidence: 91%

Section: E M Mbaawuaga Et Almentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis B Virus (HBV) Serological Patterns in Benue State, Nigeria

Mbaawuaga¹,

Iroegbu²,

Ike³

2014

OJMM

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“…Viral hepatitis due to HBV/HCV is a major cause of morbidity and mortality from acute and chronic infections (Thabit et al, 2012;Murad et al, 2013;Al-Shamahy and Abdu, 2013). About half of the population in cities and main governates have serological evidence of previous HBV infection.…”

Section: Introductionmentioning

confidence: 99%

Sero-Molecular Epidemiology and Risk Factors of Viral Hepatitis in Urban Yemen

Nabehi¹,

Shamahy²,

Saeed³

et al. 2015

International J. of Virology

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Viral hepatitis is an acute or chronic neglected disease that affects predominantly the liver. This study aimed to determine the sero prevalence and risk factors for viral hepatitis and HCV genotypes in urban areas of Yemen. In a prospective, cross-sectional, analytical and community-based study and following informed consent, 501 volunteers were randomly recruited. Demographic and clinical data was collected. Screening for HBV, HDV and HCV was carried out using ELISA. HBV/HCV viral loads and HCV genotyping were carried out using COBAS ®

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“…lipids, and can induce lipid peroxidation in-vivo [16][17][18] . In our study, TAA treatment produced the elevation in the levels of LPO.…”

Section: Discussionmentioning

confidence: 99%