Occult hepatitis B virus infection in dialysis patients: a multicentre survey

Fabrizi, F.; Messa, Piergiorgio; Lunghi, G.; Aucella, Filippo; Bisegna, Sergio; Mangano, Stefano; Villa, M.; Barbisoni, F.; Rusconi, Elena; Martin, Paul

doi:10.1111/j.1365-2036.2005.02501.x

Cited by 77 publications

(96 citation statements)

References 48 publications

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“…The data recorded from hemodialysed patients in our study were similar to those encountered in another study made in Italy [12], in which no occult infection was found in 213 patients from five different centers.…”

Section: Discussionsupporting

confidence: 76%

“…In maintenance hemodialysis patients, the risk of acquiring HBV and HCV infection is high, due to the dialysis process [12,13]; consequently, the probability of patients becoming chronic carriers is higher than for the general population. In HIV-positive patients, co-infection with HBV and HCV is common due to the common route of transmission of these diseases.…”

mentioning

confidence: 99%

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Occult hepatitis B virus infection in immunocompromised patients

Jardim¹,

Gonçales²,

Pereira³

et al. 2008

Braz J Infect Dis

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Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAgnegative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV positive patients was not a determining factor for occult HBV infection. In addition, no significant relationship between HBV-DNA and HCV co-infection in the HIV-positive patient group was found. A lack of significant associations was also observed between positivity for HBV-DNA and CD4 count, viral load and previous lamivudine treatment in these HIV-positive patients.

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Section: Discussionsupporting

confidence: 76%

mentioning

confidence: 99%

Occult hepatitis B virus infection in immunocompromised patients

Jardim¹,

Gonçales²,

Pereira³

et al. 2008

Braz J Infect Dis

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“…The prevalence of occult HBV infection in HBsAg negative patients on hemodialysis ranges between 0% and 58% in published reports. [7][8][9][10][11][12] There has been limited data about the prevalence of occult HBV infection among CRF patients in South Korea. The aim of this study was to investigate the prevalence of occult HBV infection in patients receiving hemodialysis at a single center in South Korea.…”

Section: 유정환 등 투석환자의 B형간염 바이러스 잠재감염률mentioning

confidence: 99%

Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients

Yoo

Hwang

Yang

et al. 2013

Korean J Gastroenterol

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Background/Aims: The prevalence of occult HBV infection depends on the prevalence of HBV infection in the general population. Hemodialysis patients are at increased risk for HBV infection. The aim of this study was to determine the prevalence of occult HBV infection in hemodialysis patients. Methods: Total of 98 patients undergoing hemodialysis in CHA Bundang Medical Center (Seongnam, Korea) were included. Liver function tests and analysis of HBsAg, anti-HBs, anti-HBc and anti-HCV were performed. HBV DNA testing was conducted by using two specific quantitative methods. Results: HBsAg was detected in 4 of 98 patients (4.1%), and they were excluded. Among 94 patients with HBsAg negative and anti-HCV negative, one (1.1%) patient with the TaqMan PCR test and 3 (3.2%) patients with the COBAS Amplicor HBV test were positive for HBV DNA. One patient was positive in both methods. Two patients were positive for both anti-HBs and anti-HBc and one patient was negative for both anti-HBs and anti-HBc. Conclusions: The present study showed the prevalence of occult HBV infection in HBsAg negative and anti-HCV negative patients on hemodialysis at our center was 3.2%. Because there is possibility of HBV transmission in HBsAg negative patients on hemodialysis, more attention should be given to prevent HBV transmission. (Korean J Gastroenterol 2013;61:209-214)

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“…Parenteral exposure also favors contamination by HCV (Dai et al, 2001). The studies performed up to now on hemodialysis patients provide widely divergent results, reporting a prevalence of occult HBV that ranges from 0% to 36% (Besisik et al, 2003;Fabrizi et al, 2005;Goral et al, 2006;Kanbay et al, 2006;Minuk et al, 2004;Motta et al, 2010;Siagris et al, 2006). These apparent discrepancies may be explained by significant differences in the prevalence of HBV infection in different geographic regions and/or by the detection limits of different HBV-DNA assays.…”

Section: Occult Hbv Infection In Hemodialysis Patientsmentioning

confidence: 99%