Occult Hepatitis B Virus Infection

doi:10.4328/jcam.1229

Cited by 2 publications

(1 citation statement)

References 53 publications

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“…The incidence of OBI is different in every country, for example it has been reported between 0%-36.4% in blood donors in our country (12). According to other studies, OBI was reported actullay between 3.4% and 19% in hemodialysis patients (13).…”

Section: Discussionmentioning

confidence: 63%

Which is more important and insidious in dialysis patients? Occult Hepatitis B or Occult Hepatitis C?

Gazel¹,

Şener²

2020

vhd

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Bu çalışmanın amacı hemodiyaliz hastalarında Okült hepatit B enfeksiyonu (OBE) ve Okült hepatit C enfeksiyonu (OCE) varlığını araştırmak ve izlemde aktivasyon olup olmadığını tespit etmektir. Gereç ve Yöntemler: Çalışmaya dahil edilen normal alanin aminotransferaz (ALT) düzeylerine sahip 100 HD hastasının demografik verileri, böbrek yetmezliği nedenleri, hemodiyalize erişim, hemodiyaliz süresi, ALT düzeyi, hepatit göstergeleri kaydedildi. Serum antiHBc IgG, ELISA (Architecht, Abbott) ile test edildi. Serum HBV DNA, HCV RNA (periferik kan mononükleer hücrelerinde-PKMNH) "gerçek zamanlı" polimeraz zincir reaksiyonu yöntemi ile araştırıldı. Bulgular: AntiHBc IgG pozitifliği hastaların% 27'sinde saptandı. ancak izole antiHBc IgG pozitifliği yoktu. Hastaların% 4'ünde HBV DNA pozitifliği ve OBE tespit edildi. Hiçbir hastada serum ve PBMNH'de HCV RNA pozitifliği yoktu, bu nedenle OCE saptanmadı. Beş yıllık takipte hiçbir hastada OBE veya OCE aktivasyonu gelişmedi. OBE hastalarından birinde böbrek nakli yapıldı ve oral antiviral ile yaşam boyu profilaksi planlandı. Sonuç: Hemodiyaliz hastalarında OCE varlığı OBE'den düşüktür. Anahtar Kelimeler: Okült hepatit B, Okült hepatit C, hemodiyaliz Objectives: The aim of this study was to investigate the presence of Occult hepatitis B infection (OBI) and Occult hepatitis C infection (OCI) in hemodialysis patients and to determine whether there is activation in follow-up or not. Materials and Methods: Demographic data of 100 HD patients with normal alanine aminotransferase (ALT) levels included in the study, causes of renal failure, access to hemodialysis, duration of hemodialysis, ALT levels, hepatitis indicators were recorded. Serum antiHBc IgG was tested by ELISA (Architecht, Abbott). Serum HBV DNA, HCV RNA (in peripheral blood mononuclear cells-PBMNH) were investigated by 'real-time' polymerase chain reaction method. Results: AntiHBc IgG positivity was detected in 27% of patients, but there's no antiHBc IgG positivity alone. In 4% of the patients, HBV DNA positivity and OBI infection were detected. None of the patients showed HCV RNA positivity in serum and in PBMNH, therefore OCI was not detected. None of the patients developed OBI or OCI activation in a five-years follow-up. Renal transplantation was performed in one of the OBI patients and lifelong prophylaxis was planned with oral antiviral drugs. Conclusion: Presence of OCI is lower than OBI in hemodialysis patients.

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Section: Discussionmentioning

confidence: 63%

Which is more important and insidious in dialysis patients? Occult Hepatitis B or Occult Hepatitis C?

Gazel¹,

Şener²

2020

vhd

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Kriptojenik sirozlu hastalarda okült hepatit B sıklığı

Yalakı

Yalçın

2019

Cukurova Medical Journal

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The frequency of occult hepatitis B is variable in patients with cryptogenic cirrhosis and is unknown in our region. The presence of HBV DNA in serum of cirrhotic patients can be determined by molecular techniques despite the lack HBV serological markers. We aimed to determine the frequency of occult hepatitis B virus in patients with cryptogenic cirrhosis in this study. Materials and Methods: This cross-sectional study was designed to assess the prevalence of occult HBV infection in a group of patients with cryptogenic liver cirrhosis. Forty-four patients with cryptogenic cirrhosis who were examined in our hospital were enrolled in this study. Their serum were studied for HBV DNA levels using a real-time PCR method. Results: There were 44 patients in the study group; Positive for anti-hepatitis B surface antibody was detected in 22 patients, and positive for hepatitis B core antibody was detected in 24 patients. In 2 patients, HBV DNA was found to be positive. In our study, occult HBV infection was found in 4.5% (2/44) of patients with cryptogenic cirrhosis. Conclusion: The prevalence of occult HBV infection was relatively high in patients with cryptogenic cirrhosis; Occult hepatitis B infection may thus play a role in the development of decompensated cirrhosis and complications in cases of cryptogenic liver disease.

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Occult Hepatitis B Virus Infection

Abstract: ÖzetPencere dönemi dışında Hepatit B yüzey antijeni negatif iken kan veya do-

Cited by 2 publications

References 53 publications

Which is more important and insidious in dialysis patients? Occult Hepatitis B or Occult Hepatitis C?

Which is more important and insidious in dialysis patients? Occult Hepatitis B or Occult Hepatitis C?

Kriptojenik sirozlu hastalarda okült hepatit B sıklığı

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