Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection

Jun-Hyeon, Cho; Lee, Sang Soo; Choi, Yun Suk; Jeon, Yejoo; Chung, Jung Wha; Baeg, Joo Yeong; Keun, Won; Jang, Eun Sun; Kim, Jin‐Wook; Jeong, Sook Hyang

doi:10.3748/wjg.v22.i42.9427

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…We previously reported on occult HBV infection in HCV patients 25 . According to one report, occult HBV infection is not associated with disease progression in patients with chronic HCV infection 26 . HBV co-infection reportedly can also cause HCC.…”

Section: Discussionmentioning

confidence: 99%

Persistent Hepatic Inflammation Plays a Role in Hepatocellular Carcinoma After Sustained Virological Response in Patients with HCV Infection

Nirei¹,

Nakamura²,

Matsuoka³

et al. 2018

Int. J. Med. Sci.

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Objective: Hepatitis C virus (HCV) infection has long been treated with interferon therapy (IFN). Currently, more than 90% of IFN-treated patients show a sustained virological response (SVR) when also treated with ribavirin and/or a protease inhibitor. Histological inflammation and fibrosis improve in IFN-treated patients, which indicates HCV clearance. IFN also reduces the incidence of hepatocellular carcinoma (HCC). However, a small proportion of patients with SVR develop HCC. To investigate the causes of hepatic carcinogenesis after SVR, we compared the liver histological findings before IFN to those after the development of HCC.Patients and methods: In total, 602 patients infected with type C chronic hepatitis or with liver cirrhosis who received IFN therapy during the period from 1992 through 2015 were included in this study. We assessed 14 of the 287 patients who achieved an SVR.Results: HCC was diagnosed by computed tomography, angiography or liver biopsy. The longest time from the SVR until HCC detection was 16.5 years, and the mean was 7.2±4.6 years. Nine of the 14 patients underwent surgery and one radiofrequency ablation. The histological findings of 10 patients were available for comparison. The comparison of the histological findings before treatment with those after the HCC diagnosis revealed an amelioration of liver fibrosis and other inflammatory changes. All ten patients showed improvements in fibrosis and steatosis. However, we observed that mild inflammatory change persisted from 1.8 years to 16.5 years after the confirmation of SVR in all cases.Conclusion: We suspect that persistent histological inflammation is one of the factors contributing to hepatocarcinogenesis (i.e., HCC development) even after successful treatment.

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Section: Discussionmentioning

confidence: 99%

Persistent Hepatic Inflammation Plays a Role in Hepatocellular Carcinoma After Sustained Virological Response in Patients with HCV Infection

Nirei¹,

Nakamura²,

Matsuoka³

et al. 2018

Int. J. Med. Sci.

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“…High prevalence rates of OBI are observed among patients with hepatitis C (HCV, 1%-20%) (Almeida et al, 2019;Cho et al, 2016;Mandour et al, 2015;Yamaji et al, 2018), patients with HIV (10%-40%) and patients with HCC (>40%) (Ndjoyi-Mbiguino et al, 2018;Dinesha et al, 2018;Saha et al, 2017). The relatively high prevalence reported in HCV or HIV-infected populations and HCC patients might be due to the fact that clinic triggered more frequent investigations in these populations.…”

Section: Prevalence Of Obi In the Worldmentioning

confidence: 99%

Occult Hepatitis B virus (HBV) infection and challenges for hepatitis elimination: A literature review

Almeida

Paula

2022

Journal of Applied Microbiology

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Occult hepatitis B infection (OBI) is characterized by the detection of hepatitis B virus (HBV) DNA in serum or liver but negativity for hepatitis B surface antigen. OBI, which is thought to be maintained by host, immunological, viral and/or epigenetic factors, is one of the most challenging clinical features in the study of viral hepatitis. Currently, there is no validated detection test for OBI. It is believed that OBI is widely distributed throughout the world, with a higher prevalence in populations at high-risk HBV, but the detailed worldwide prevalence patterns are unknown. We conducted a survey of recently published studies on OBI rates across all continents.High prevalence rates of OBI are observed in some specific groups, including patients with hepatitis C virus, human immunodeficiency virus co-infection or hepatocellular carcinoma. In 2016, the World Health Organization adopted strategies to eliminate viral hepatitis by 2030, but the difficulties in detecting and treating OBI currently challenge this goal. Subjects with OBI can transmit HBV, and episodes of reactivation can occur. Further studies to understanding the mechanisms that drive the development of OBI are needed and can contribute to efforts at eliminating viral hepatitis.

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“…In some studies, the absence of an interaction between OBI and chronic hepatitis C was observed, 45,46 while others have identified that some mutations in HBV may favor its occult phenotype in chronic HCV carriers. 47 OBI has been suggested to be associated with hepatocarcinogen-…”

Section: Discussionmentioning

confidence: 99%

Occult hepatitis B virus infection in patients with chronic liver disease of different etiology in a Brazilian referral center: comparison of two different hepatitis B virus deoxyribonucleic acid amplification protocols: a cross-sectional study

et al. 2023

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BACKGROUND: Occult hepatitis B virus infection (OBI) is defined as the presence of hepatitis B virus (HBV) deoxyribonucleic acid (DNA) in the liver of individuals with undetectable hepatitis B virus surface antigen (HBsAg) in the serum. The actual prevalence of OBI and its clinical relevance are not yet fully understood. OBJECTIVE: To evaluate the prevalence of HBV DNA in liver biopsies of HBsAg-negative patients with chronic liver disease of different etiologies in a referral center in Brazil and compare two different HBV DNA amplification protocols to detect HBV.

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Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection

Cited by 7 publications

References 36 publications

Persistent Hepatic Inflammation Plays a Role in Hepatocellular Carcinoma After Sustained Virological Response in Patients with HCV Infection

Persistent Hepatic Inflammation Plays a Role in Hepatocellular Carcinoma After Sustained Virological Response in Patients with HCV Infection

Occult Hepatitis B virus (HBV) infection and challenges for hepatitis elimination: A literature review

Occult hepatitis B virus infection in patients with chronic liver disease of different etiology in a Brazilian referral center: comparison of two different hepatitis B virus deoxyribonucleic acid amplification protocols: a cross-sectional study

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