Occult Hepatitis B Virus Infection in Patients With Chronic Hepatitis C Treated With Antiviral Therapy

Caviglia, Gian Paolo; Abate, Maria Lorena; Manzini, Paola; Danielle, Franca; Ciancio, Alessia; Rosso, Chiara; Olivero, Antonella; Pellicano, Rinaldo; Touscoz, Giovanni Antonio; Smedile, Antonina; Rizzetto, M.

doi:10.5812/hepatmon.7292

Cited by 10 publications

(30 citation statements)

References 28 publications

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“…Therefore, our results indicated that presence of HBV-DNA could cause an inhibitory influence on elevation of liver enzymes, and provides additional support for the opinion that HBV-DNA has inhibitory interference on HCV activity. Also, the result of normal liver enzymes in our patients with OBI were comparable to many studies that failed to demonstrate the association between OBI and elevation of liver enzymes in patients with HCV (17, 24, 27, 28). However, other studies reported a direct correlation between the presence of OBI and flare liver enzymes (29, 30).…”

Section: Discussionsupporting

confidence: 88%

Prevalence of Occult Hepatitis B Virus in Plasma and Peripheral Blood Mononuclear Cell Compartments of Patients WithChronic Hepatitis C Infection in Tehran-Iran

et al. 2013

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BackgroundOccult hepatitis B virus (HBV) infection (OBI) is frequently reported in patients with chronic hepatitis C virus (HCV) infection. An association between OBI and more liver damage, cirrhosis, hepatocellular carcinoma, and reduced response to interferon therapy in patients with HCV infection is suggested.ObjectivesThe aim of this study was to determine the prevalence of occult HBV, and evaluate its clinical influence on patients with chronic HCV.Patients and MethodsA cohort study including50 patients with positive results for HCV, and negative results for HBsAg tests was performed. The patients were divided into two groups: one group had positive results for both HCV and occult HBV tests (n = 18), and the other had positive results for HCV, but negative findings for occult HBV (n = 32). All were treated with PEG-IFN alpha-2a and Ribavirin. Presence of HCV RNA was followed in these patients.ResultsHBV-DNA was detected using nested-PCR in 20% of plasma and 32.6% of peripheral blood mononuclear cell (PBMC) compartments. No significant differences were observed between patients with and without occult HBV for sex, age, duration of HCV infection, histological markers, presence of anti-HBc, HCV viral load, and HCV genotype. The response rate was significantly higher in patients with positive results for HBV-DNA test compared to those with negative findings (100% vs. 71.9 %, P < 0.05).ConclusionsIn conclusion, occult HBV was found in 36% of patients with negative results for HBsAg, but positive results for HCV. Detection of HBV-DNA in both PBMCs and plasma together in comparison with plasma alone provided more true identification of OBI.The SVR rate was significantly higher in coinfected patients than mono-infected ones.

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Section: Discussionsupporting

confidence: 88%

Prevalence of Occult Hepatitis B Virus in Plasma and Peripheral Blood Mononuclear Cell Compartments of Patients WithChronic Hepatitis C Infection in Tehran-Iran

et al. 2013

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“…The main characteristics of the 34 studies included in the meta-analysis are summarized in Tables 1 and 2; 6 26,29,42,45,51,53 evaluated the prevalence of OBI in subjects without chronic liver disease, 30 5,7,[22][23][24][25][26][27][28][30][31][32][33][34][35][36][37][38][39][40][41][43][44][45][46][47][48][49][50]52 in those with chronic liver disease and 2 26,45 in both. All were cross-sectional studies, but 3 7,46,50 were cohort studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Overall, the studies included a total of 2729 HBsAg-negative subjects. Of the 34 studies included, sixteen were conducted in Italy, 5,7,[33][34][35]37,39,[41][42][43]45,48,49,[51][52][53] seven in the United States, 22,26,30,32,36,44,47 four in France, 23,24,27,46 two in Spain, 25,28 one each in Austria, 31 United Kingdom, 29 Germany 40 and Portugal, 50 and one was a multinational European study. 28 Considering the six studies enrolling subjects without chronic liver disease, 3 45 4 studies involved only patients with HCC.…”

Section: Study Characteristicsmentioning

confidence: 99%

An estimation of the prevalence of occult HBV infection in Western Europe and in Northern America: A meta‐analysis

Pisaturo

Onorato

Russo

et al. 2019

Journal of Viral Hepatitis

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Data on the prevalence of occult HBV infection (OBI) in Western Europe and in Northern America are few; hence, we conducted a systematic review and meta‐analysis. All studies included had to fulfil the following inclusion criteria: (a) they investigated the prevalence of OBI (HBV DNA in liver tissue in HBsAg‐negative subjects), (b) were carried out in Western Europe and in Northern America; (c) were available as a full‐text manuscript, (d) written in English and (e) published up to December 2018. The exclusion criteria were as follows: (a) meta‐analyses, letters, reviews, meeting abstracts or editorial comments; (b) studies investigating HBsAg‐positive patients; (c) those investigating OBI outside Western Europe and in Northern America; and (d) to avoid small sample bias in the random‐effects model, those enrolling less than five subjects. Thirty‐four studies met the inclusion criteria, allowing a meta‐analysis on 2729 patients. The overall prevalence of OBI was 34% (95% CI = 26%‐42%), 28% (CI 95%: 12%‐48%) in 329 subjects without chronic liver disease and 35% (95% CI 26%‐44%) in 2400 patients with chronic liver disease. The prevalence of OBI was 51% (95% CI 40%‐62%) in the 823 anti‐HBc‐positive subjects and 19% (95% CI 10%‐30%) in the 1,041 anti‐HBc‐negative subjects. Evaluating the data from 17 studies comparing anti‐HBc‐positive and negative subjects, the prevalence of OBI was higher in the 641 anti‐HBc‐positive subjects than in the 1041 anti‐HBc‐negative (prevalence ratio = 2.29; 95% CI = 1.61‐3.26, P < .001). This meta‐analysis showed that in HBsAg‐negative subjects the prevalence of OBI was high and was associated with anti‐HBc positivity.

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“…OBI was investigated as previously described [18]. Briefly, extracted liver DNAs were analyzed for the presence of HBV genomes by four parallel nested-PCRs to detect HBV S, Core, Pol and X sequences (sensitivity threshold at 5 IU/mL).…”

Section: Detection Of Intrahepatic Hbv-dna and Obi Definitionmentioning

confidence: 99%

Prediction of occult hepatitis B virus infection in liver transplant donors through hepatitis B virus blood markers

Tandoi

Caviglia

Pittaluga

et al. 2014

Digestive and Liver Disease

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Occult Hepatitis B Virus Infection in Patients With Chronic Hepatitis C Treated With Antiviral Therapy

Cited by 10 publications

References 28 publications

Prevalence of Occult Hepatitis B Virus in Plasma and Peripheral Blood Mononuclear Cell Compartments of Patients WithChronic Hepatitis C Infection in Tehran-Iran

Prevalence of Occult Hepatitis B Virus in Plasma and Peripheral Blood Mononuclear Cell Compartments of Patients WithChronic Hepatitis C Infection in Tehran-Iran

An estimation of the prevalence of occult HBV infection in Western Europe and in Northern America: A meta‐analysis

Prediction of occult hepatitis B virus infection in liver transplant donors through hepatitis B virus blood markers

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