Occult hepatitis B virus infection in Greek patients with chronic hepatitis C and in patients with diverse nonviral hepatic diseases*

Georgiadou, Sarah P.; Zachou, Kalliopi; Rigopoulou, Eirini I.; Liaskos, Christos; Mina, Paraskevi; Gerovasilis, F.; Makri, E.; Dalekos, George Ν.

doi:10.1111/j.1365-2893.2004.00513.x

Cited by 46 publications

(45 citation statements)

References 52 publications

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“…The obtained results were confirmed by other studies as well (1,9,11,(20)(21)(22)(23)(24). The number of studies that have established an association between the presence of occult HBV infection and the genotype of HCV virus is small (25,26), serum level of HCV RNA (9,13,15) or transaminase activity (25,27).…”

Section: Discussionsupporting

confidence: 77%

Positive HBV DNA in liver samples in patients with chronic HCV infection

Simonova¹,

Hadzhiolova²,

Pavlova³

et al. 2016

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PURPOSE:To determine prevalence of positive HBV DNA in liver tissue samples in patients with chronic HCV infection (CHCV) and to investigate whether there is an association between it and underlying clinical condition. METHODE: For the period 2004 -2010 in the Gastroenterology Clinic at the Military Medical Academy -Sofia, 96 patients CHCV (77% males, 23% females, mean age 50, 5 ± 10, 02 years) -chronic hepatitis (n-42), cirrhosis (n-35) and НСС (n-19) were included in the study. All of them were HBs Ag -negative. Liver samples were tested for the presence on of tree gene regions of HBV: S-, Core-and Х-antigen coding regions. Serum levels of HBV DNA were also investigated. RESULTS: Positive liver HBV DNA was found in 40,6% of patients with CHCV. The presence of Sgen coding region was detected in 82% (n-32), Core-gen coding region -in 87% (n-34) and Х -gen coding region -in 46,1% (n-18) of cases. Occult HBV infection was significantly associated with the presence of cirrhosis and HCC (P<0,0001) and with positive serum markers for past HBV infection (P=0,001). The prevalence of positive serum HBV DNA (20,8%) was significantly lower than the prevalence of positive liver HBV DNA (P<0,0001). CONCLUSION: Positive liver HBV DNA was found in 40,6% of cases with CHCV, which is significantly higher than the presence of positive serum HBV DNA (20,8%) in the same patients. Occult HBV infection in patients with CHCV was associated with more severe liver damage in comparison with the patients monoinfected with HCV.

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Section: Discussionsupporting

confidence: 77%

Positive HBV DNA in liver samples in patients with chronic HCV infection

Simonova¹,

Hadzhiolova²,

Pavlova³

et al. 2016

TJS

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“…In contrast, HBV DNA has been found in serum by PCR in 6.7% to 52% (13,15,16) of HBsAg-negative patients with chronic HCV infection, in 5% to 76% (7,10,30) of patients with chronic liver disease of no defi ned etiology, and in 0% (15) to 15% (21) of healthy donors.…”

Section: Discussionmentioning

confidence: 95%

“…Despite evidence that co-infection may accelerate the progress to liver disease (9,41) , be related to the emergence of HCC (34,37,38) , and adversely infl uence the response to HCV treatment (7,9,13,41) , other studies show that occult infection does not interfere with the natural history of the disorder in this population (12,15,16,22) .…”

Section: Introductionmentioning

confidence: 99%

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Occult hepatitis B virus infection in patients with chronic liver disease due to hepatitis C virus and hepatocellular carcinoma in Brazil

Branco

Mattos

Coral

et al. 2007

Arq. Gastroenterol.

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-Background -The prevalence and consequences of occult HBV infection in patients with chronic liver disease by HCV remain unknown. Aims -To evaluate the prevalence of occult HBV infection in a population of HCV-infected patients with hepatocellular carcinoma. Methods -The serum samples were tested for HBV DNA by nested PCR and liver tissue analysis was carried out using the immunohistochemical technique of 66 HBsAg-negative patients: 26 patients with chronic hepatitis by HCV (group 1), 20 with hepatocellular carcinoma related to chronic infection by HCV (group 2) and 20 with negative viral markers for hepatitis B and C (control group). Results -Occult HBV infection was diagnosed in the liver tissue of 9/46 (19.5%) HCV-infected patients. Prevalence of occult B infection was evaluated in the HCV-infected patients with and without hepatocellular carcinoma, and there were seven (77.7%) of whom from group 2, conferring a 35% prevalence of this group. No serum sample was positive for HBV DNA in the three groups. Conclusion -Occult infection B is frequently detected in liver tissue of HCV-infected patients, especially in cases of hepatocellular carcinoma. However large studies are needed to confi rm that co-infection could determine a worse progress of chronic liver disease in this population.

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“…The role of occult HBV infection in chronic hepatitis C virus (HCV) infection is perhaps the most extensively studied. Cacciola et al (29) not only found higher rates of occult HBV infection among patients with HCV-related chronic liver disease but also found liver cirrhosis more frequently among chronic HCV patients with (76,91,128,133,191,241). Occult HBV infection has been associated with liver enzyme flares during chronic HCV infection (235) without changes in HCV RNA levels (127).…”

Section: Clinical Relevancementioning

confidence: 99%

Molecular Mechanisms Underlying Occult Hepatitis B Virus Infection

2012

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SUMMARY Chronic hepatitis B virus (HBV) infection is a complex clinical entity frequently associated with cirrhosis and hepatocellular carcinoma (HCC). The persistence of HBV genomes in the absence of detectable surface antigenemia is termed occult HBV infection. Mutations in the surface gene rendering HBsAg undetectable by commercial assays and inhibition of HBV by suppression of viral replication and viral proteins represent two fundamentally different mechanisms that lead to occult HBV infections. The molecular mechanisms underlying occult HBV infections, including recently identified mechanisms associated with the suppression of HBV replication and inhibition of HBV proteins, are reviewed in detail. The availability of highly sensitive molecular methods has led to increased detection of occult HBV infections in various clinical settings. The clinical relevance of occult HBV infection and the utility of appropriate diagnostic methods to detect occult HBV infection are discussed. The need for specific guidelines on the diagnosis and management of occult HBV infection is being increasingly recognized; the aspects of mechanistic studies that warrant further investigation are discussed in the final section.

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Occult hepatitis B virus infection in Greek patients with chronic hepatitis C and in patients with diverse nonviral hepatic diseases*

Cited by 46 publications

References 52 publications

Positive HBV DNA in liver samples in patients with chronic HCV infection

Positive HBV DNA in liver samples in patients with chronic HCV infection

Occult hepatitis B virus infection in patients with chronic liver disease due to hepatitis C virus and hepatocellular carcinoma in Brazil

Molecular Mechanisms Underlying Occult Hepatitis B Virus Infection

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