Occult metastases from supraglottic laryngeal carcinoma

Petrović, Z; Krejović, B; Janosević, S

doi:10.1046/j.1365-2273.1997.00061.x

Cited by 21 publications

(28 citation statements)

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“…In our study females comprised almost one-third of the study population, and the mean age of them was not significantly different than for male patients as reported by others [20]. Women with laryngeal carcinoma generally do better than men [2,7,17,26]. The possible explanations of it involved among others less advanced disease and lower age at the time of diagnosis or more hygienic life style.…”

Section: Discussionsupporting

confidence: 45%

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Predictors of radiotherapy outcome in patients with T2 supraglottic carcinoma

Rutkowski

Wygoda

Składowski

et al. 2011

Eur Arch Otorhinolaryngol

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The decision regarding treatment of early supraglottic carcinoma remains controversial. Single institution clinical data of patients with T2 supraglottic carcinoma treated exclusively with radiotherapy in terms of prognostic factors and treatment results were analyzed. Patient-related factors that would potentially by useful for optimal therapeutic decision to be undertaken were especially investigated. Between 1994 and 2004, 78 patients with T2 supraglottic carcinoma underwent radiotherapy (RT) in Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Poland. There were 54 (69%) males and 24 (31%) females in the median age of 61 years. There were 17 (22%) patients with N+. Median body mass of patients before (BM0) and after RT (BM1) was 74 kg (range 45.2-130 kg) and 72.9 kg (range 49.9-122.5 kg), respectively. Median hemoglobin concentrations before (Hb0) and after (Hb1) RT were 14.3 and 13.4 g/dl, respectively. Median change of Hb concentration during RT (dHb) was -0.8 g/dl. All were treated up to total doses (TD) ranged from 62.5 to 72 Gy. The overall treatment time (OTT) ranged from 30 to 70 days. Estimates of local control (LC), ultimate local control (uLC), and overall survival (OS) were calculated using the Kaplan-Meier method. Log rank statistics, Cox proportional hazard model and step-wise Cox regression hazard model were employed to identify prognostic factors for LC, uLC, and OS in univariate and multivariate analyses. The 5-year LC, RC, uLC and OS rates were 85, 92, 88, and 56%, respectively. In multivariate analysis N+ (p = 0.01) and prolonged OTT (p = 0.03) significantly decreased LC. Females (p = 0.02), higher BM0 (p = 0.03), and HB0 (p = 0.006) significantly prolonged OS. Patient-related factors like gender, hemoglobin concentration, and body mass may predict treatment outcome. Radiotherapy is effective for T2 supraglottic carcinoma of the larynx unless higher dose intensity is provided. Involved regional lymph nodes significantly deteriorate locoregional cure.

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Section: Discussionsupporting

confidence: 45%

“…The best treatment for early supraglottic carcinoma has been a matter of debate for years mostly due to significant possibility of regional spread of disease [2,7]. Single modalities of surgery or radiotherapy are both options for such patients.…”

Section: Discussionmentioning

confidence: 99%

Predictors of radiotherapy outcome in patients with T2 supraglottic carcinoma

Rutkowski

Wygoda

Składowski

et al. 2011

Eur Arch Otorhinolaryngol

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“…A 10% rate of occult metastases has been consistently demonstrated in glottic recurrence patients who were N0 initially and at recurrence . In contrast, supraglottic cancers have been reported to present with occult nodes in up to 43% of cases, and transglottic cancers with even higher rates…”

Section: Introductionmentioning

confidence: 99%

Occult nodal disease in patients with failed laryngeal preservation undergoing surgical salvage

et al. 2013

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“…The reported highest density of lymphatic collectors in the triangle between the epiglottis, the false vocal cord, and the aryepiglottic fold28, 30 could explain the high prevalence of nodal metastases in supraglottic carcinoma with no statistically significant difference between marginal and vestibular tumors (47% vs 38%). No significant difference in occult metastases has also been reported from these subsites 36…”

Section: Discussionmentioning

confidence: 80%