Occult neoplastic cells in the lymph node sinuses and recurrence of primary breast, lung, esophageal, and gastric cancer

Mukai, Masaya; Sato, Shinkichi; Nakasaki, Hisao; Tajima, Takayuki; Saito, Yuichi; Nishiumi, Noboru; Iwasaki, Masayuki; Tokuda, Yutaka; Ogoshi, Kyoji; Inoue, Hiroshi; Makuuchi, Hiroyasu

doi:10.3892/or.11.1.81

Cited by 17 publications

(28 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At this time, the antibody to cytokeratin is widely used for detection of lymph node metastasis from breast cancer [4,5] . However,a current study showed that the sensitivity of cytokeratin to lymph node metastasis from gastrointestinal cancer is low [6] . Recently, receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is recognized as type II membrane protein and secreted as a soluble protein [7,8] .…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers

Leelawat

Engprasert²,

Tujinda³

et al. 2005

WJG

View full text Add to dashboard Cite

Abstract Abstract Abstract AIM:To investigate the expression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) in metastatic lymph nodes from gastrointestinal cancer. METHODS:Metastatic lymph nodes from gastrointestinal cancer were detected for RCAS1 by immunohistochemical staining and mRNA in situ hybridization. RESULTS:A total of 102 metastatic lymph nodes from bile duct, gastric, colon, and pancreatic cancer were investigated for RCAS1 expression. The immunoreactivity of RCAS1 was identified in 100% of metastatic lymph nodes. Both local and distant metastatic lymph nodes showed RCAS1 expression. On the contrary, specimens of non-cancerous lymph nodes were negative for RCAS1. The result of mRNA in situ hybridization was also confirmed by the finding of immunohistochemical staining. RCAS1 mRNA was detected in all tumor cells that metastasized to lymph nodes. CONCLUSION:All metastatic lymph nodes express RCAS1 in tumor cells at both protein and mRNA levels, and RCAS1 should be used as a complementary factor for identification of metastatic lymph nodes from gastrointestinal cancers.

show abstract

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers

Leelawat

Engprasert²,

Tujinda³

et al. 2005

WJG

View full text Add to dashboard Cite

show abstract

“…Hematogenous metastasis to the liver or the lungs in patients with lymph node metastasis who undergo curative resection is presumed to occur when cancer cells circulating in the blood during the perioperative period, escape the immune system enter the microcirculation of the liver or the lungs, and find appropriate microenvironment for growth and proliferation (7)(8)(9)(10). Various reports have been published about the close relationship between recurrence/metastasis of cancer and detection of occult neoplastic cells (ONCs) positive for cytokeratin immunohistochemical staining and floating in the sinuses of lymph nodes distant from the primary tumors (11)(12)(13)(14)(15). ONCs can be semiquantified by a relatively simple immunostaining method and represent floating tumor cells target trapped in the microcirculation of the lymph nodes, which are part of the immune mechanism (7,8).…”

Section: Introductionmentioning

confidence: 99%

Occult neoplastic cells in the lymph node sinuses and recurrence/metastasis of stage III/Dukes' C colorectal cancer

Sekido

Mukai²,

Kishima³

et al. 2011

Oncol Rep

View full text Add to dashboard Cite

Abstract.Lymph nodes from patients with colorectal cancer were immunohistochemically stained for cytokeratin to investigate the relationship between the presence of occult neoplastic cells (ONCs) and recurrence/metastasis. A total of 80 patients with stage III/Dukes' C colorectal cancer were divided into 16 patients who developed recurrence/metastasis (recurrence group) and 64 patients without recurrence (nonrecurrence group). ONCs were compared between the two groups with respect to i) single cells (≥3 floating ONCs), ii) clusters of cells (1 or more floating aggregates of 2-20 ONCs) and iii) single cells + clusters. When single cells were detected, the sensitivity for recurrence was 87.5% (14/16, p=0.002), the positive predictive value (PPV) was 32.6% (14/43), the specificity was 54.7% (35/64) and the negative predictive value (NPV) was 94.6% (35/37). For clusters, the sensitivity was 87.5% (14/16, p<0.001), PPV was 41.2% (14/34), specificity was 68.8% (44/64) and NPV 95.7% (44/46). With single cells + clusters, the values were 87.5% (14/16, p<0.001), 48.3% (14/29), 76.6% (49/64) and 96.1% (49/51), respectively. These results suggest that the detection of single cells + clusters is a sensitive indicator of a high risk of recurrence/metastasis, while ONCs are useful for identifying the low-risk group of patients with stage III colorectal cancer. IntroductionThe 5-year survival rate of Japanese patients who have stage II/ Dukes' B colorectal cancer without lymph node metastasis and receive curative resection is approximately 80% (colon, 84.5±2.8%; rectum, 79.8±4.0%), whereas the 5-year survival rate is considerably lower at approximately 60% (colon, 74.0±3.5%; rectum, 64.7±4.3%) for patients with stage III/ Dukes' C colorectal cancer and lymph node metastasis who undergo curative resection (1-4). Thus, recurrence/metastasis develops in 30-40% of stage III/Dukes' C patients after curative resection and can be fatal (2,4). According to the pathological concept of breast cancer, positive lymph node metastasis indicates systemic disease with the potential for metastasis to other organs and the presence or absence of lymph node metastasis is considered to be one of the most important clinical markers (5,6). Hematogenous metastasis to the liver or the lungs in patients with lymph node metastasis who undergo curative resection is presumed to occur when cancer cells circulating in the blood during the perioperative period, escape the immune system enter the microcirculation of the liver or the lungs, and find appropriate microenvironment for growth and proliferation (7-10). Various reports have been published about the close relationship between recurrence/metastasis of cancer and detection of occult neoplastic cells (ONCs) positive for cytokeratin immunohistochemical staining and floating in the sinuses of lymph nodes distant from the primary tumors (11-15). ONCs can be semiquantified by a relatively simple immunostaining method and represent floating tumor cells target trapped in the microcirculation of the lymph node...

show abstract

“…Unlike other gastrointestinal malignancies, including gastric cancer, surgery is still indicated for colorectal cancer even when it has metastasized to distant organs such as the liver and lungs (6,7). It is also known that colorectal cancer may cause fatal metastasis/recurrence in the liver or lungs after curative resection of the primary tumor, probably because free cancer cells circulate during the perioperative period and survive to proliferate in a distant organ after escaping from the immune system (8)(9)(10)(11). Many investigators have reported that cytokeratin-positive occult neoplastic cells (ONCs), which represent circulating cancer cells, in lymph node sinuses distant from the primary tumor are closely related to the distant metastasis/recurrence of cancer (12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

“…Many investigators have reported that cytokeratin-positive occult neoplastic cells (ONCs), which represent circulating cancer cells, in lymph node sinuses distant from the primary tumor are closely related to the distant metastasis/recurrence of cancer (12)(13)(14)(15)(16)(17)(18)(19). ONCs can be counted by immunostaining and represent floating malignant cells that have been trapped by the lymph nodes (8)(9)(10)(11). ONC clusters (<10 cells) formed by a number of floating ONCs or malignant micro-aggregates (≥10 cells) can induce the metastasis/recurrence of cancer in distant organs after being released from the primary tumor.…”

Section: Introductionmentioning

confidence: 99%

Alternating hepatic arterial infusion and systemic chemotherapy for stage IV colorectal cancer with synchronous liver metastasis

Mukai

Oida²,

Tajima³

et al. 2006

Oncol Rep

Self Cite

View full text Add to dashboard Cite

Abstract. Among 41 patients with synchronous liver metastases of colorectal cancer, 15 patients underwent synchronous resection of their liver metastases and achieved a median survival time (MST) of 1,441 days (versus 748 days for the 26 patients without resection, p=0.038), a median relapse-free survival time of 652 days (MST not reached), and a recurrence rate in the residual liver of 20% (3/15 patients). The alternating hepatic arterial infusion and systemic chemotherapy showed partial response (PR) in 6 cases, stable disease (SD) in 8 cases, and progressive disease (PD) in 1 case (n=15/26). They had an objective response rate of 40% (6/15), tumor control rate (≥ SD) of 93.3% (14/15), one-year progression-free survival rate of 35.7%, 50% time to progression of 270 days, one-year survival rate of 76.2%, and two-year survival rate of 50.8% (MST not reached). Grade 3 leucopenia was observed in 2/15 patients (13.3%). These results suggest that the present alternating therapy may become a standard regimen for patients in whom synchronous resection of liver metastases is impossible and patients who have stage IV colorectal cancer with a risk of recurrence in the remnant liver and/or at extrahepatic sites such as the lungs.

show abstract

Occult neoplastic cells in the lymph node sinuses and recurrence of primary breast, lung, esophageal, and gastric cancer

Cited by 17 publications

References 0 publications

Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers

Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers

Occult neoplastic cells in the lymph node sinuses and recurrence/metastasis of stage III/Dukes' C colorectal cancer

Alternating hepatic arterial infusion and systemic chemotherapy for stage IV colorectal cancer with synchronous liver metastasis

Contact Info

Product

Resources

About