Occult primary breast cancer presenting with brachial plexopathy: A case report

Zhao, Karen L; Liu, Yusha; Scherpelz, Kathryn P; Kao, Dennis S.; Friedrich, Jeffrey B.

doi:10.1177/2050313x20985646

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…The present definition of OBC is a kind of primary breast cancer diagnosed histologically by biopsy of axillary lymph nodes but without clinical or radiographic finding (mammography and ultrasonography) in the breast itself [ 2 , 3 ]. The incidence of OBC among all types of breast cancer is about 0.1 to 1% [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics and treatment outcomes of occult breast cancer: a population-based study

et al. 2022

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Background Occult breast cancer (OBC) is a special type of breast cancer. Because of its rarity, clinicopathological information is still insufficient, causing a controversial condition about its treatment recommendation. Thus, we aimed to clarify major clinicopathological information, treatment strategies and prognosis of OBC based on a large population. Methods We retrospectively collected adult female OBC population from Surveillance, Epidemiology, and End Results database. We divided the whole cohort into two groups based on surgical treatment in-breast. Descriptive analysis of 18 clinicopathological variables was conducted. Survival analysis was performed based on different clinicopathological factors. Univariate and multivariate Cox regression analysis was performed to identify potential independent predictor for prognosis of OBC. Results 1189 OBC patients were in final analysis and most of them were diagnosed as an early-stage carcinoma. Patients received breast-conserving treatment (BCT) was nearly two times of ones received mastectomy. Patients receiving radiotherapy in BCT group were significantly more than patients receiving radiotherapy in mastectomy group (61.76 vs. 50.9%, P < 0.001). After a median follow-up period of 62 months, 5-year and 10-year overall survival (OS) of all subjects was 81.6% and 68.8%, respectively. No significant difference in OS and breast-cancer specific survival (BCSS) was found between mastectomy and local breast-conserving surgery. Older age and larger number of positive lymph nodes causes a worse prognosis whereas radiotherapy brought a better clinical outcome for OBC patients. Conclusions OBC has a generally good prognosis. Less-intensive surgery does not negatively impact clinical outcomes of OBC while additional radiotherapy is totally beneficial to prolong OS and BCSS.

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Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics and treatment outcomes of occult breast cancer: a population-based study

et al. 2022

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“…At present, OBC is histologically diagnosed in the axillary lymph nodes through biopsy, but no clinical or radiographic methods, such as mammography, ultrasonography (US), or magnetic resonance imaging (MRI), have been found to be suitable ( 2 ). The incidence of OBC among all types of breast cancer is about 0.1%–1% ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: Unique ultrasound feature of thyroid metastases in occult breast cancer

et al. 2022

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Occult breast cancer is an uncommon type of breast cancer. Metastases of occult breast cancer to other tissues are rather rare. We present a rare case of thyroid metastases in a 46-year-old woman who underwent occult breast cancer. The first ultrasound (US) examination of the thyroid showed that the left lobe was enlarged but had normal thyroid function. At first, this case was misdiagnosed as thyroiditis based on the thyroid US features. However, the cytological and histological results showed that nests of the neoplastic cells were found. Further immunohistochemistry results confirmed that these neoplasms were derived from breast tissue. Analysis using the successive US scans revealed that the sizes and echo of the thyroid repeatedly changed after the radiotherapy and chemotherapy treatment. To our knowledge, this is the first reported case of occult breast carcinoma presenting with thyroid metastases. This case can easily be misdiagnosed as thyroiditis due to the metastasis area not manifesting as regular suspicious nodules or diffused punctate calcifications.

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Occult primary breast cancer presenting with brachial plexopathy: A case report

Cited by 2 publications

References 25 publications

Clinicopathological characteristics and treatment outcomes of occult breast cancer: a population-based study

Clinicopathological characteristics and treatment outcomes of occult breast cancer: a population-based study

Case report: Unique ultrasound feature of thyroid metastases in occult breast cancer

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