Occult sclerosing carcinoma of the thyroid

Klinck, G. H.; Winship, Theodore

doi:10.1002/1097-0142(1955)8:4<701::aid-cncr2820080412>3.0.co;2-v

Cited by 61 publications

(16 citation statements)

References 6 publications

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“…However, the evaluation of thyroid disorders in the presence of GH and IGF-I excess has yielded conflicting results, since the prevalence of thyroid disease in acromegaly ranged from 25% to 92% in different series (7)(8)(9)(10)(11)(12)(13)(14). These discrepancies may be partially explained by differences in how goiter was diagnosed: palpation, imaging studies, such as US, or evaluation of iodine intake in the area.…”

Section: Discussionmentioning

confidence: 99%

“…IGF-I acts by means of two mechanisms: increasing proliferation and reducing apoptosis. It was demonstrated that IGF-I increases proliferation of porcine thyroid cells and FRTL-5 rat thyroid cells, and potentiates TSH-mediated thyroid cell proliferation (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). In physiological conditions, thyroid follicular cells express IGF-I receptors.…”

Section: Discussionmentioning

confidence: 99%

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Thyroid nodules in acromegaly

Rogozinski

Furioso

Glikman

et al. 2012

Arq Bras Endocrinol Metab

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Objective: We made a prospective study evaluating the prevalence of thyroid nodular disease in acromegalic patients. Subjects and methods: Thyroid ultrasound and ultrasound-guided fine needle aspiration biopsy were performed when nodules were detected. Nodules were characterized by cytology and histopathology. Results: We found high prevalence of nodular thyroid disorder, 23/34 (67%) in acromegalic patients. High risk and malignant cytology were significantly higher in acromegalic patients than in our non-acromegalic population (25% vs. 9%). Differentiated thyroid carcinoma was present in 11% of the acromegalic patients. Conclusions: We strongly recommend periodic thyroid evaluation by ultrasound in patients with acromegaly. Fine needle aspiration biopsy should be performed in nodules larger than 10 mm, and in all suspicious nodules, regardless of the size. Arq Bras Endocrinol Metab. 2012;56(5):300-4 Keywords Acromegaly; thyroid nodules; thyroid ultrasonography; fine needle aspiration biopsy; thyroid carcinoma RESUMO Objetivo: Realizamos um estudo prospectivo avaliando a prevalência de patologia nodular tireói dea em 34 pacientes acromegálicos. Sujeitos e métodos: Avaliamos os pacientes com ecografia tireóidea e punção biópsia com agulha fina quando se detectavam nódulos. Resultados: Encontramos uma alta prevalência de patologia nodular tireóidea 23/34 (67%) em acromegálicos. A citologia tireóidea de alto risco e maligna foi significativamente mais elevada em pacientes acromegálicos que em uma população não acromegálica (25% vs. 9%). O grupo acromegálico apresentou carcinoma diferenciado de tireoides em 11%. Conclusões: Recomendamos fortemente a ecografia periódica tireóidea em pacientes acromegálicos. Uma punção biópsia aspirativa com agulha fina deve ser realizada em presença de nódulos tireóideos maiores que 10 mm e daqueles com critérios ecográficos suspeitos de malignidade, independentemente do tamanho deles. Arq Bras Endocrinol Metab. 2012;56(5):300-4

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Thyroid nodules in acromegaly

Rogozinski

Furioso

Glikman

et al. 2012

Arq Bras Endocrinol Metab

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“…Fine‐needle aspiration (FNA) is an excellent test for the diagnosis of papillary carcinoma of the thyroid due to its characteristic cytologic features 1–3. Nevertheless, papillary tumors are relatively small tumors compared to other types of thyroid tumors,4 many tumors are 1 cm or less,4–9 and the size of tumors that are resected may be decreasing 10. Although FNA can identify papillary tumors less than 1 cm,10–12 how effective FNA is for tumors that are very small is not clear.…”

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confidence: 99%

Sensitivity of fine‐needle aspiration for papillary carcinoma of the thyroid correlates with tumor size

Renshaw

2011

Diagnostic Cytopathology

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Fine-needle aspiration (FNA) of the thyroid for papillary carcinomas is highly sensitive. We sought to determine if the sensitivity of FNA for papillary carcinoma is correlated with the size of the tumor. We reviewed the results of thyroid resections for the last 12 years and correlated the findings with clinical and cytologic information. During the time period, a total of 1,331 resections were performed, and a total of 501 papillary carcinomas were identified, including 291 classic tumors, 65 follicular variants, and 145 "incidental" tumors. Sensitivity for all tumors was strongly correlated with tumor size and ranged from a sensitivity of 0-3% for tumors 2 mm or less, 90% for tumors 1-3 cm (220/244, P < 0.001) and 83% for tumors above 3 cm (47/59, P = 0.02). Abnormal FNAs of classic tumors were always recognized as papillary (262/262) compared to only 49% of follicular variants (32/65, P < 0.001). The sensitivity of FNA for papillary thyroid carcinoma is strongly correlated with tumor size. Tumors smaller than 0.5 cm and tumors larger than 3 cm may be more difficult to successfully aspirate on FNA, and the follicular variant may be more difficult to recognize as papillary.

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“…. 1 Routine clinical, radiological, biochemical or cytological assessments fail to detect the presence of a carcinoma. The postoperative histopathological analysis reveals the presence of ITC.…”

Section: Introductionmentioning

confidence: 99%