Occupation and bladder cancer among men in Western Europe

Kogevinas, Manolis; Mannetje, Andrea ’t; Cordier, Sylvaine; Ranft, Ulrich; González, Carlos A.; Víneis, Paolo; Chang‐Claude, Jenny; Lynge, Elsebeth; Wahrendorf, Jürgen; Τζώνου, Αναστασία; Jöckel, Karl‐Heinz; Serra, Consol; Porru, Stefano; Hours, Martine; Greiser, Eberhard; Boffetta, Paolo

doi:10.1023/b:caco.0000007962.19066.9c

Cited by 219 publications

(191 citation statements)

References 28 publications

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“…An in vitro investigation carried out by Wolf et al (Wolf et al, 2005) found that cells treated with benzo [a] pyrene showed a dramatic increase in the expression of CYP1A1. Similar conclusions were also found in other experimental animals whose bladder cells were exposed to tobacco containing compounds such as benzo[a]pyrene and arylamines (Kogevinas et al, 2003;Dorrenhaus et al, 2007). However, we failed to reveal any evidence of an association between the two CYP1A1 polymorphisms and BC susceptibility overall, regardless of the additive, dominant, or recessive genetic models.…”

Section: Discussionsupporting

confidence: 89%

Lack of Association Between CYP1A1 Polymorphisms and Risk of Bladder Cancer: a Meta-analysis

Zhang²,

Xie³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The effects of CYP1A1 gene polymorphisms on the risk of bladder cancer (BC) remain controversial. We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in BC. Material and Methods: A comprehensive literature search was conducted up to November 20, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Meta-regression, subgroup analysis, sensitivity analysis and publication bias were also performed. Results: Eight studies involving 1,059 BC cases and 1,061 controls were included. The meta-analysis showed that there was no significant association between the two common mutations of CYP1A1 and BC risk. For the I1e462Val A/G polymorphism with GG vs. AA the OR was 1.47 (95 % CI= 0.70-3.07, P =0.308). For the MspI T/C polymorphism, though a slight trend was found this was not statistically nonsignificant (CC vs.TT, OR = 1.24, 95 % CI= 0.98-1.58, P =0.078). Subgroup analyses by ethnicity also found no obvious association between CYP1A1 and BC risk. Conclusion: The present meta-analysis suggests that CYP1A1 polymorphism is not associated with bladder cancer risk.

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Section: Discussionsupporting

confidence: 89%

Lack of Association Between CYP1A1 Polymorphisms and Risk of Bladder Cancer: a Meta-analysis

Zhang²,

Xie³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Occupational exposure to the following chemical agents is associated with an increased risk of bladder cancer: aromatic amines, paints and solvents, dyes, leather dust, polycyclic aromatic hydrocarbons (PAH), motor exhaust, and chlorinated hydrocarbons (1,(5)(6)(7)(8). Further epidemiologic research is required for many other potential bladder carcinogens.…”

mentioning

confidence: 99%

Male bladder cancer risk and occupational exposure according to a job-exposure matrix—a case-control study in British Columbia, Canada

Richardson¹,

Band²,

Astrakianakis³

et al. 2007

Scand J Work Environ Health

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“…The two established risk factors for TCC are chemical carcinogens from cigarette smoking and occupation exposure (Zeegers et al, 2000;Kogevinas et al, 2003). Bulky DNA adducts formed by these carcinogens are repaired by nucleotide excision repair (NER).…”

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confidence: 99%

The polyAT, intronic IVS11-6 and Lys939Gln XPC polymorphisms are not associated with transitional cell carcinoma of the bladder

et al. 2005

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Chemical carcinogens from cigarette smoking and occupational exposure are risk factors for bladder transitional cell carcinoma (TCC). The Xeroderma Pigmentosum Group C (XPC) gene is essential for repair of bulky adducts from carcinogens. The Xeroderma Pigmentosum Group C gene polymorphisms may alter DNA repair capacity (DRC), thus giving rise to genetic predisposition to bladder cancer. Recent studies have demonstrated linkage disequilibrium between three polymorphisms in the XPC gene (polyAT, IVS11-6 and Lys939Gln) and these have been shown to influence the DRC, as well as to be associated with bladder cancer risk. We analysed all three XPC polymorphisms in 547 bladder TCC patients and 579 cancer-free controls to investigate the association between these polymorphisms and bladder cancer susceptibility, and we also attempted to assess gene -environmental interactions. We confirmed strong linkage disequilibrium among the polymorphisms (Lewontin's D 0 40.99). Using logistic regression adjusting for smoking, occupational and family history, neither the heterozygote nor the homozygote variants of these polymorphisms were associated with increased bladder cancer risk (adjusted odds ratio

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Occupation and bladder cancer among men in Western Europe

Abstract: Metal workers, machinists, transport equipment operators and miners are among the major occupations contributing to occupational bladder cancer in men in Western Europe. In this population one in 10 to one in 20 cancers of the bladder can be attributed to occupation.

Cited by 219 publications

References 28 publications

Lack of Association Between CYP1A1 Polymorphisms and Risk of Bladder Cancer: a Meta-analysis

Lack of Association Between CYP1A1 Polymorphisms and Risk of Bladder Cancer: a Meta-analysis

Male bladder cancer risk and occupational exposure according to a job-exposure matrix—a case-control study in British Columbia, Canada

The polyAT, intronic IVS11-6 and Lys939Gln XPC polymorphisms are not associated with transitional cell carcinoma of the bladder

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