Occupation and Risk of Parkinsonism

Tanner, Caroline M.; Ross, G. Webster; Jewell, Sarah A.; Hauser, Robert A.; Jankovic, Joseph; Factor, Stewart A.; Bressman, Susan; Deligtisch, Amanda; Marras, Connie; Lyons, Kelly E.; Bhudhikanok, Grace S.; Roucoux, Diana F.; Meng, Cheryl; Abbott, Robert D.; Langston, J. William

doi:10.1001/archneurol.2009.195

Cited by 224 publications

(80 citation statements)

References 46 publications

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“…Previous studies that, like ours, obtained information on exposure to pesticides from interviews have this potential (4)(5)(6)(7)(8)(9)(10)(11)21). Nevertheless, two cohort studies using prospective self-reports of exposure, which should not be prone to recall bias, found associations between exposure to pesticides as a group and risk of Parkinson's disease (12,13).…”

Section: Rugbjerg Et Almentioning

confidence: 59%

“…An association between pesticides and Parkinson's disease was first suspected in 1983, when the chemical 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which has a chemical structure similar to the herbicide paraquat, was observed to cause acute Parkinsonism (3). Since then, exposure to pesticides and subsequent development of Parkinson's disease has been studied intensively (eg, [4][5][6][7][8][9][10][11][12][13][14][15][16][17] and many studies (4)(5)(6)(7)(8)(12)(13)(14)(15)(16)(17) have confirmed associations, though some were weak and not significant, and other studies did not find an effect (9,10).…”

mentioning

confidence: 99%

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Pesticide exposure and risk of Parkinson’s disease – a population-based case–control study evaluating the potential for recall bias

Rugbjerg¹,

Harris²,

Shen³

et al. 2011

Scand J Work Environ Health

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Section: Rugbjerg Et Almentioning

confidence: 59%

mentioning

confidence: 99%

Pesticide exposure and risk of Parkinson’s disease – a population-based case–control study evaluating the potential for recall bias

Rugbjerg¹,

Harris²,

Shen³

et al. 2011

Scand J Work Environ Health

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“…Exposure to welding was addressed in eight studies (24,26,28,30,43,49,58,60), giving a weighted RR of 0.85 (95% CI 0.82-0.89), and exposure to metals in other forms was addressed in five studies (21,24,26,29,32), giving a weighted RR of 0.98 (95% CI 0.53-1.81). There was no indication of publication bias.…”

Section: Exposure To Metalsmentioning

confidence: 99%

“…In some studies, separate risk estimates are presented for different types of pesticides (18,19,22,23,26,38,44,55,56,59,60); the risk estimates are somewhat higher for insecticides and herbicides compared to fungicides. Pesticides are designed to interfere with cellular mechanisms, and so it is not surprising that exposure to any pesticides seems to exert an increased risk for Parkinson's disease.…”

Section: Other Exposuresmentioning

confidence: 99%

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Parkinson’s disease and occupational exposures: a systematic literature review and meta-analyses

Gunnarsson

Bodin²

2017

Scand J Work Environ Health

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Parkinson's disease and occupational exposures: a systematic literature review and meta-analyses by Gunnarsson L-G, Bodin L Contrary to previously published meta-analyses in this field, our meta-analyses are based only on studies fulfilling good standards of scientific quality. Thus the results of this review are not hampered by biases from studies of lower scientific quality and are also discussed in relation to today's knowledge of pathophysiological mechanisms for Parkinson's disease and Parkinsonism. Affiliation 197Review Scand J Work Environ Health. 2017;43(3):197-209. doi:10.5271/sjweh.3641 Parkinson's disease and occupational exposures: a systematic literature review and meta-analyses GRADE guidelines were used to ensure high scientific quality, and reliable guidelines were applied to classify the papers. Of the 103 articles, 47 fulfilled good scientific standards while 56 were methodologically deficient and thus excluded from our meta-analyses.Results A total of 23 publications concerned work exposure to pesticides. The weighted relative risk estimate was 1.67 (95% confidence interval 1.42-1.97). A funnel plot and bias test indicated that some publication bias concerning smaller studies might have been present. The risk estimate was not influenced by study design (casecontrol, cohort, or cross-sectional study) or gender. Higher estimates were found when there was a hereditary taint or onset below age 60. Studies on exposure to metals or electromagnetic fields did not show increased risk. ConclusionsUsing an elaborated quality protocol, there is now strong evidence that exposure to any pesticide involves a ≥50% increased risk for developing Parkinson's disease.

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Neurotoxicology and Behavior

Boyes¹

2012

Patty's Toxicology

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Neurotoxicity is important to consider as a component of occupational and environmental safety and health programs. The failure to do so has contributed to a number of cases in which workers, consumers of manufactured products, and people exposed in the environment were irreparably harmed by exposure to compounds that proved toxic to the nervous system. The field of neurotoxicology originated in response to several episodes of mass poisoning and developed through advances in clinical practice, scientific research, and regulatory actions. This chapter reviews broadly the development of the field of neurotoxicity and discusses some of the predominant current issues. The chapter includes an introduction to the structure and function of the nervous system, the response to injury, the evaluation of sensory, cognitive, and motor functions, and effects on emotionality, mood, and social conduct. Recently, there has been a growing emphasis on potential toxic effects on neurodevelopment and contributions to neurodegenerative diseases. Also, there is a large and growing effort to develop more rapid and cost‐efficient screening tests for potential neurotoxicity. A brief overview of some of the major classes of neurotoxic substances is provided including metals, solvents, pesticides, and persistent organic compounds. Finally, the need for programs to prevent neurotoxic illness is discussed.

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Occupation and Risk of Parkinsonism

Cited by 224 publications

References 46 publications

Pesticide exposure and risk of Parkinson’s disease – a population-based case–control study evaluating the potential for recall bias

Pesticide exposure and risk of Parkinson’s disease – a population-based case–control study evaluating the potential for recall bias

Parkinson’s disease and occupational exposures: a systematic literature review and meta-analyses

Neurotoxicology and Behavior

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