Occupational Abnormalities and Contact Dermatitis

Baran, Robert; Rycroft, R. J. G.

doi:10.1002/9781118286715.ch9

Cited by 3 publications

(4 citation statements)

References 165 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our retrospective, observational study was conducted from January 2008 to December 2022. All consecutive YNS-diagnosed patients were included after exclusion of differential diagnoses, e.g., nail discoloration caused by exogenous products able to modify nails, like drugs ( d -penicillamine, bucillamine, tiopronin), mycosis (Candida, Aspergillus ), nail infection ( Pseudomonas aeruginosa responsible for chloronychia (green rather than yellow nail discoloration), professional causes (homemakers, barbers, dishwashers, bakers, medical personnel), and, finally, toxic causes, such as pesticides, chromium salts, and epoxy systems [11, 14]. Other very rare causes of yellow nail discoloration in children and adults were excluded, e.g., lichen planus, psoriasis or alopecia areata, chronic paronychia, onychogryphosis, and acquired pachyonychia [11].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment

Benassaia,

Abba,

Fourgeaud

et al. 2023

Dermatology

View full text Add to dashboard Cite

Background. Yellow nail syndrome (YNS), a very rare disorder of unknown etiology, is characterized by a triad associating yellow nails, respiratory manifestations and lymphedema. YNS treatment remains non-codified. Methods. This retrospective study was conducted from January 2008 to December 2022 in a single tertiary department exclusively dedicated to lymphatic diseases. All consecutive patients with YNS were included. Results. Thirteen men and 10 women were included in the study. Three patients had yellow nails at birth or during childhood. For the other 20 patients, median (Q1–Q3) age at first sign was 50.8 (43–61) years. Median (Q1–Q3) first-YNS-sign-to-diagnosis interval was 17 (10–56) months. For 4 patients, YNS was associated with primary intestinal lymphangiectasia. The first YNS sign was chronic cough (45.5%), followed by yellow nails (27.3%), chronic sinusitis (18.2%) and lymphedema (9.1%). At first consultation, among these 23 patients, 69.6% had the complete triad, all had yellow nails and cough, 82.6% chronic sinusitis and 69.6% lymphedema. Lymphedema involved only the lower limb (n=12), lower and upper limbs (n=2), the lower and upper limb and face (n=2). Nineteen (82.6%) patients were treated with fluconazole (100 mg/d, (n=8) or 300 mg/wk, (n=11)) combined with vitamin E (1000 mg/d) for a median of 13 months. Responses were complete for 4 (21.1%) patients, partial for 8 (42.1%) and therapeutic failures for 7 (36.8%). Conclusion. YNS is a rare disease that almost always starts with a chronic cough. Despite inconstant efficacy, fluconazole–vitamin E in combination can be prescribed to treat yellow nails.

show abstract

Section: Methodsmentioning

confidence: 99%

“…Nineteen (82.6%) patients were treated with combined fluconazole-vitamin E for a median [Q1-Q3] of 13 [7][8][9][10][11][12][13][14] months. The oral fluconazole dose was 100 mg/day (n = 8) or 300 mg/week (n = 11), in combination with vitamin E 1,000 mg/day for all patients.…”

Section: Yellow Nail Treatmentmentioning

confidence: 99%

Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment

Benassaia,

Abba,

Fourgeaud

et al. 2023

Dermatology

View full text Add to dashboard Cite

show abstract

“…Yet, certain factors could affect the nails on a more local level. For instance, abnormalities of the nail apparatus caused by occupational hazards, such as excess use of irritants or inadequate protection of the hands, have been described [43]. In addition, certain pathogens specifically target nails [32,43,44].…”

Section: Correlation With Age and Differences Between Sampling Locationsmentioning

confidence: 99%

“…For instance, abnormalities of the nail apparatus caused by occupational hazards, such as excess use of irritants or inadequate protection of the hands, have been described [43]. In addition, certain pathogens specifically target nails [32,43,44]. For one, onychomycosis has been reported as being the most common nail disease worldwide [45], leading to the question whether it might affect the results of the assay.…”

Section: Correlation With Age and Differences Between Sampling Locationsmentioning

confidence: 99%

Age determination through DNA methylation patterns in fingernails and toenails

Fokias

Dierckx

Voorde

et al. 2023

Forensic Science International: Genetics

View full text Add to dashboard Cite

Yellow nail syndrome: a review

Vignes¹,

Baran

2017

Orphanet J Rare Dis

Self Cite

118

136

View full text Add to dashboard Cite

Yellow nail syndrome (YNS; OMIM 153300, ORPHA662) is a very rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed. YNS is diagnosed based on a triad associating yellow nail discoloration, pulmonary manifestations (chronic cough, bronchiectasia, pleural effusion) and lower limb lymphedema. Chronic sinusitis is frequently associated with the triad. YNS etiology remains unknown but a role of lymphatic impairment is usually evoked. YNS is more frequently isolated but may be associated in rare cases with autoimmune diseases, other clinical manifestations implicating lymphatic functions or cancer and, hence, is also considered a paraneoplastic syndrome. YNS management is symptomatic and not codified. YNS can resolve spontaneously. Oral vitamin E alone or even better when associated with triazole antifungals may achieve partial or total disappearance of nail discoloration. Pleural effusion can be treated surgically, with decortication/pleurectomy or pleurodesis. Antibiotic prophylaxis is prescribed for bronchiectasia with chronic sputum production. Lymphedema treatment is based on low-stretch bandages and the wearing of elastic compression garments combined with skin care, exercises and, as needed, manual lymph drainage.

show abstract

Occupational Abnormalities and Contact Dermatitis

Cited by 3 publications

References 165 publications

Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment

Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment

Age determination through DNA methylation patterns in fingernails and toenails

Yellow nail syndrome: a review

Contact Info

Product

Resources

About