Occupational airborne contact dermatitis caused by trifluoroacetic acid in an organic chemistry laboratory

Byun, Ji Yeon; Woo, Ju Yun; Choi, You Won; Choi, Hae Young

doi:10.1111/cod.12138

Cited by 11 publications

(5 citation statements)

References 7 publications

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“…Two patch tests were performed with 1% solutions of 5 chemicals including TFA, and positive reactions were observed for TFA in both tests. Although other substances also produced positive reactions, the authors of the original report concluded that the allergen with the highest association with the patient was TFA and diagnosed the case as allergic contact dermatitis triggered by TFA (Byun et al (2013)).…”

Section: Skin Sensitizationmentioning

confidence: 99%

Derivation of permitted daily exposure value for trifluoroacetic acid as an impurity in pharmaceutical products

Sanada,

Kikuno,

Kitamura

et al. 2023

Fundam. Toxicol. Sci.

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Trifluoroacetic acid (TFA) has been used for production of pharmaceuticals including recently emerging middle size peptides. TFA has severe local toxicity like skin and respiratory tract irritation due to the strong acidity. Because almost all pharmaceutical products are prepared at neutral pH, derivation of permitted daily exposure (PDE) of TFA from the information with neutralized form could provide useful information on the risk management for protection of patients and production of pharmaceuticals. Sodium TFA caused hepatotoxicity in a rat 90-day. Based on the results of the 90-day study, we respectively proposed PDE for oral, parenteral and inhalation routes as 1.7, 0.005 and 0.84 mg/person/ day. The derivation of PDE was done according to the concept described in ICH Q3C(R8) and Q3D(R2).

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Section: Skin Sensitizationmentioning

confidence: 99%

Derivation of permitted daily exposure value for trifluoroacetic acid as an impurity in pharmaceutical products

Sanada,

Kikuno,

Kitamura

et al. 2023

Fundam. Toxicol. Sci.

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“…Bu ilk adımdan sonra topikal (steroidler, topikal kalsinörin inhibitörler, nemlendiriciler) ve sistemik (steroidler, metotreksat, azothioprin) gibi birçok ajan kullanılabilir (42)(43)(44)(45)(46). Ancak tedavinin kısa ve uzun dönemde başarısının esas anahtarı kontakt dermatit etkenini bulup ortadan kaldırmaktır, nitekim ajanla teması kesilemeyen olgularda şikayetler işe dönünce tekrarlamaktadır (42).…”

Section: Tedavi Ve Korunmaunclassified

Mesleksel Havayla Taşınan (Airborne) Kontakt Dermatitler

2015

Dermatoz

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ÖzetMesleksel Havayla Taşınan (Airborne) Kontakt Dermatitler Günümüzde sanayideki gelişmeler çok sayıda irritan ve allerjene mesleksel maruziyeti beraberinde getirmekte ve bu durum da mesleki dermatozlarda çeşitliliğe neden olmaktadır. Bunlardan birisi de Havayla Taşınan (Airborne) kontakt dermatit (ABKD) olarak tanımlanan; toz, sprey, polen ve uçucu kimyasalların duman veya partiküllerinin havayolu aracılığı ile deriye teması sonucu oluşan farklı bir kontakt dermatit formudur. ABKD'ler epidemiyolojik olarak mesleksel ve mesleksel olmayan olmak üzere ikiye ayrılmaktadır. Mesleksel olmayan ABKD'ler genellikle bitkisel kaynaklıdır. Mesleksel ABKD'lerden ise ilaçlar, dezenfektanlar, bitki ve ağaç ürünleri, plastikler, lastikler, yapıştırıcılar, metaller, insektisidler, pestisidler, solventler gibi çok sayıda irritan veya allerjik ajanlar sorumludur. Mesleksel ABKD tanı koyma aşamasındaki sorunlar nedeniyle hem hasta hem de doktor için büyük bir bulmacaya dönüşebilir. Bu yazıda mesleksel ABKD'lerin epidemiyolojik ve klinik özellikleri literatür bilgileri ışığında değerlendirilmiştir.Anahtar Kelimeler: Meslek hastalığı, mesleki dermatoz, airborne kontakt dermatit Abstract Occupational Airborne Contact DermatitisNowadays, industrial developments bring a large number of occupational irritant and allergen exposure and this situation is causing diversity in occupational dermatoses. One of them is airborne contact dermatitis (ABCD) which is a different form of contact dermatitis resulting from contact with powders, spray, pollen, and smoke of volatile chemicals or particles flying through the skin. ABCDs are epidemiologically divided into two groups; occupational and non-occupational. Non-occupational ABCDs are usually vegetable origin. A large number of allergens and irritants such as drugs, disinfectants, plant and wood products, plastics, rubber, adhesives, metals, insecticides, pesticides and solvents are responsible for occupational ABCD. Occupational ABCD because of problems at stage of diagnosis can turn into a big puzzle for both patient and doctor. In this article, the epidemiological and clinical characteristics of occupational ABCD were evaluated in the view of literature.

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“…En esta revisión, se han encontrado 3 nuevos casos de DCAT por químicos comunicados en los últimos años [33][34][35] . Dentro de las publicaciones más recientes cabe destacar el estudio realizado en 2008 por Braun-Falco M. sobre Kathon CG, éste agente es el principal irritante dermatológico de origen químico estudiado 44,45 , siendo este trabajo uno de los pocos estudios que relacionan la exposición a Kathon con la aparición de cuadros de dermatitis aerotransportada 46 .…”

Section: Discusión Y Conclusionesunclassified

“…También llama la atención los resultados del estudio más reciente publicado hasta la fecha (Enero 2014) acerca de la capacidad irritativa del TFA por vía aerotransportada 33 , un reactivo utilizado en síntesis orgánica, del cual no se había descrito en la literatura como agente causal de DCAT [44][45][46][47][48] .…”

Section: Discusión Y Conclusionesunclassified

“…Por ello, se ha podido concluir que la mayor parte de los casos de DCAT en los trabajadores de la industria química, farmacéutica y sanitaria pueden ser debidos a una exposición directa al alérgeno, más que a una condición individual de susceptibilidad, teniendo en cuenta que la mayoría de los síntomas mejoran con un tratamiento tópico adecuado e incluso llegan a desaparecer cuando el trabajador deja de estar en contacto con el alérgeno 42,33 .…”

Section: Discusión Y Conclusionesunclassified

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Dermatitis aerotrasportada de origen laboral en la industria química, farmacéutica y sector sanitario

Cervera

Perdomo

Barbero³

2014

Med. segur. trab.

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MEDICINA y SEGURIDAD del trabajo Octubre -diciembre 2014 Med Segur Trab (Internet) 2014 60 (237) 742-755 Dermatitis aerotransportada de origen laboral en la industria química, farmacéutica y sector sanitario Jaureguizar Cervera E., Pérez Perdomo M., Reinoso Barbero, L. 742 RevisionesDermatitis aerotrasportada de origen laboral en la industria química, farmacéutica y sector sanitarioAirborne contact dermatitis in chemical and pharmaceutical industry and healthcare sectorsJaureguizar Cervera E. ResumenIntroducción: La dermatitis de contacto aerotransportada (DCAT), es una forma de dermatitis profesional que por su manifestación clínica, localización y forma de contacto presentan característica propias, este hecho junto con la relevancia de la dermatosis dentro de la morbilidad profesional justifica la necesidad de sintetizar la evidencia científica existente mediante una revisión sistemática.Objetivos: Identificar la evidencia científica sobre la DCAT, la existencia de un consenso sobre criterios diagnósticos, las medidas de prevención y la identificación de población especialmente sensible. Material y métodos:Revisión sistemática de la producción científica publicada entre 2006 y 20014 sobre DCAT, se realizó una búsqueda sistemática mediante términos DeCS, MeSH, en diversas bases de datos y otros recursos informáticos (MEDLINE, COCHRANE, SCOPUS, SCIELO, OVID, BNCS, OSH, UPDATE). La evidencia se evaluó con los criterios SIGN.Resultados: Tras el proceso de selección el resultado final fue de 15 artículos a analizar del total recuperado de 504. Los tipos de diseño: 1 Ensayo Clínico no aleatorizado sin grupo control y 14 Series de Casos, de los cuales 7 usaron grupo control. Las sustancias químicas que produjeron DCAT no publicadas previamente fueron: TFA, fibras PP y PE, Dihidrocloruro 2 2'-azobis (2-metilpropanamida) y HBTU 743MEDICINA y SEGURIDAD del trabajoNo se puede demostrar ninguna población especialmente sensible, se puede concluir que la DCAT está cobrando importancia, y que se debe mejorar la producción científica con diseños que generen un mayor nivel de evidencia que permitan tomar las medidas preventivas adecuadas. (Internet) 2014; 60 (237) Med Segur Trab AbstractIntroduction: Due to its location, clinical signs and form of contact, the airborne contact dermatitis (ABCD) is a unique type of occupational dermatitis. It results unquestionable the need of synthetising the scientific evidence through a systematic review taking into account the dermathoses relevance in the occupational morbidity.Objectives: To identify the scientific evidence for ABCD, the existence of a consensus on diagnostic criteria, on preventive measures and on the identification of especially sensitive population. Material and methods:A systematic review of the scientific literature published between 2006 and 2014 about ABCD. A systematic search was performed using DeCS, MeSH, in various databases and other computer resources (MEDLINE, COCHRANE, SCOPUS, SCIELO, OVID, BNCS, OSH, UPDATE). The evidence was evaluated following a ...

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Occupational airborne contact dermatitis caused by trifluoroacetic acid in an organic chemistry laboratory

Cited by 11 publications

References 7 publications

Derivation of permitted daily exposure value for trifluoroacetic acid as an impurity in pharmaceutical products

Derivation of permitted daily exposure value for trifluoroacetic acid as an impurity in pharmaceutical products

Mesleksel Havayla Taşınan (Airborne) Kontakt Dermatitler

Dermatitis aerotrasportada de origen laboral en la industria química, farmacéutica y sector sanitario

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