Occupational airborne contamination in South Brazil: 2. Oxidative stress detected in the blood of workers of incineration of hospital residues

Possamai, Fabricio Pagani; Avila, Silvio; Budni, Patrícia; Backes, P.; Parisotto, Eduardo Benedetti; Rizelio, Viviane Maria; Torres, M. A.; Colepicolo, Pio; Filho, Danilo Wilhelm

doi:10.1007/s10646-009-0387-1

Cited by 11 publications

(18 citation statements)

References 26 publications

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“…However, CAT activity showed no difference in the resident group before the antioxidant intervention, while markedly increased values were detected in directly (134.2%) and indirectly (127.8%) exposed workers compared to controls. GPx showed decreased activity in all exposed groups, also resembling the profile found in underground workers exposed to coal extraction [1], as in individuals exposed to SHSR incineration [2]. Similarly, Nadif and collaborators [13] found lower GPx activity in the blood from active miners compared to retired ones.…”

Section: After the Antioxidant Interventionsupporting

confidence: 54%

“…All the methodological procedures as well as the experimental design, including the geographic localization used in this study by our laboratory are published in detail elsewhere [1][2][3][4].…”

Section: Methodsmentioning

confidence: 99%

“…At the end of 6 months of antioxidant supplementation, a second sample collection was performed and again the same oxidative stress biomarkers were evaluated to verify the possible beneficial effect of vitamins C and E supplementation. The studied population, exclusion and inclusion criteria, and assays related to biomarkers of oxidative stress are described elsewhere [1][2][3][4]. Determination of heavy metal contents were carried out in urine samples, which were maintained frozen until the analyses, and were collected together with the first blood samples, as mentioned above.…”

Section: Experimental Designmentioning

confidence: 99%

“…We have conducted several studies on occupational contamination using the same experimental design and protocol, measuring the same OS markers in both workers directly or indirectly exposed, as well as in subjects (residents) living near the different PM emission sources: coal mining [1], incineration of solid residues of health services (SRHS) [2], and coal combustion by an electric power plant [3]. We have also demonstrated that a six month period of a combined daily antioxidant intervention with vitamins E and C (800 mg and 500 mg, respectively) was able to significantly attenuate such systemic OS associated with each type of airborne contamination [4], through a general improvement of both enzymatic and non-enzymatic antioxidant defenses present in the blood of all the exposed subjects and decreasing markers of oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

“…Mineral coal mining activity gives rise to environmental contamination by generating emissions of particulate matter (PM) during the extraction, beneficiation, combustion, and processing of minerals, eliciting systemic OS [1]. Similarly, incineration SRHS produces distinct contaminants such as heavy metals, dioxins, furans, poliaromathic hydrocarbons, among others, promoting systemic OS as well [2]. In addition, inherent to the process of energy generation, emissions from electric power plants also expose humans to several occupational diseases, due to the high content of redox-cycling organic chemicals, including metals, which are also implicated in the ROS overgeneration and therefore systemic OS [3].…”

Section: Introductionmentioning

confidence: 99%

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Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Possamai¹,

Avila²,

Filho³

2015

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Emissions of different types of airborne particulate matter (PM) is associated either with occupational contamination that affect both, workers directly exposed to the distinct PM sources such as incineration of solid residues of health services, coal mining and also coal burning derived from an electric-power plant, as well as the population living in the vicinity of such emissions. Such contamination leads to endogenous overgeneration of reactive oxygen species (ROS) in different cells and tissues and therefore to a systemic oxidative stress (OS). Enzymatic and non-enzymatic OS biomarkers were measured in the blood of workers directly and indirectly (near the emissions) exposed and also in subjects indirectly exposed living in the vicinities of these PM emissions, before and after a six months antioxidant intervention of a daily oral supplementation of vitamins C (500 mg) and E (400 mg). Compared to baseline values, the antioxidant intervention after 6 months was able to confer a consistent and protective effect against the systemic OS irrespective of the PM source of the airborne contaminants. The results clearly indicate that supplementation with antioxidant vitamins could be recommended in order to attenuate the deleterious consequences of a systemic OS associated with such PM emissions.

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Section: After the Antioxidant Interventionsupporting

confidence: 54%

Section: Methodsmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Possamai¹,

Avila²,

Filho³

2015

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Antioxidant therapy attenuates oxidative stress in the blood of subjects exposed to occupational airborne contamination from coal mining extraction and incineration of hospital residues

et al. 2010

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Coal mining and incineration of solid residues of health services (SRHS) generate several contaminants that are delivered into the environment, such as heavy metals and dioxins. These xenobiotics can lead to oxidative stress overgeneration in organisms and cause different kinds of pathologies, including cancer. In the present study the concentrations of heavy metals such as lead, copper, iron, manganese and zinc in the urine, as well as several enzymatic and non-enzymatic biomarkers of oxidative stress in the blood (contents of lipoperoxidation = TBARS, protein carbonyls = PC, protein thiols = PT, α-tocopherol = AT, reduced glutathione = GSH, and the activities of glutathione S-transferase = GST, glutathione reductase = GR, glutathione peroxidase = GPx, catalase = CAT and superoxide dismutase = SOD), in the blood of six different groups (n = 20 each) of subjects exposed to airborne contamination related to coal mining as well as incineration of solid residues of health services (SRHS) after vitamin E (800 mg/day) and vitamin C (500 mg/day) supplementation during 6 months, which were compared to the situation before the antioxidant intervention (Ávila et al., Ecotoxicology 18:1150-1157, 2009; Possamai et al., Ecotoxicology 18:1158-1164, 2009). Except for the decreased manganese contents, heavy metal concentrations were elevated in all groups exposed to both sources of airborne contamination when compared to controls. TBARS and PC concentrations, which were elevated before the antioxidant intervention decreased after the antioxidant supplementation. Similarly, the contents of PC, AT and GSH, which were decreased before the antioxidant intervention, reached values near those found in controls, GPx activity was reestablished in underground miners, and SOD, CAT and GST activities were reestablished in all groups. The results showed that the oxidative stress condition detected previously to the antioxidant supplementation in both directly and indirectly subjects exposed to the airborne contamination from coal dusts and SRHS incineration, was attenuated after the antioxidant intervention.

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Accumulation of Damage Due to Lifelong Exposure to Environmental Pollution as Dietary Target in Aging

Gabbianelli

Fedeli

Nasuti

2016

Molecular Basis of Nutrition and Aging

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Occupational airborne contamination in South Brazil: 2. Oxidative stress detected in the blood of workers of incineration of hospital residues

Cited by 11 publications

References 26 publications

Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Antioxidant therapy attenuates oxidative stress in the blood of subjects exposed to occupational airborne contamination from coal mining extraction and incineration of hospital residues

Accumulation of Damage Due to Lifelong Exposure to Environmental Pollution as Dietary Target in Aging

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