Occupational allergic contact dermatitis from a glue, containing isothiazolinones and N‐methylol‐chloroacetamide, in a carpenter

Pereira, Fȧtima; Rafael, Margarida; Pereira, MF

doi:10.1111/j.1600-0536.1999.tb06068.x

Cited by 19 publications

(7 citation statements)

References 12 publications

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“…Methylchloroisothiazolinone and methylisothiazolinone are preservatives commonly found in personal care products such as cosmetics, shampoos, and conditioners . They can also be found in nontoiletry products such as glues.…”

Section: Discussionmentioning

confidence: 99%

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Allergic contact dermatitis to slime: The epidemic of isothiazolinone allergy encompasses school glue

Zhang

Boyd

Asch

et al. 2018

Pediatric Dermatology

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The slime craze is all the rage among tweens. Slime is a homemade stretchy play material created by mixing together household items such as school glue, borax, shaving cream, and contact lens solution. We present a case of allergic contact dermatitis secondary to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in school glue used to make slime; mass spectroscopy confirmed MCI/MI in the patient's glue. Clinicians should be aware of slime as an emerging source of MCI/MI contact allergy.

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Section: Discussionmentioning

confidence: 99%

“…They can also be found in nontoiletry products such as glues. There have been case reports of allergic contact dermatitis (ACD) to MI in shoe glue, MI and benzisothiazolinone in wallpaper glue, and MCI/MI and N‐methylol‐chloroacetamide in carpentry white glue …”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis to slime: The epidemic of isothiazolinone allergy encompasses school glue

Zhang

Boyd

Asch

et al. 2018

Pediatric Dermatology

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“…11 Isothiazolinones are newly recognized adhesive allergens; MI, MCI/MI, and BIT have been reported in industrial adhesives. [12][13][14][15][16] A study of 1745 Finnish patch test patients revealed 36 patients with occupationally related MCI and/or MI sensitivity including 1 case attributed to glue exposure in a carpenter. 17 In addition to occupational exposures to isothiazolinones in glue, consumers are also at risk.…”

mentioning

confidence: 99%

Isothiazolinone Content of US Consumer Adhesives: Ultrahigh-Performance Liquid Chromatographic Mass Spectrometry Analysis

Goodier¹,

Zang²,

Siegel³

et al. 2019

Dermatitis

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Background: There are limited data regarding the prevalence and concentration of isothiazolinone preservatives in consumer adhesives. Objectives:The aim of this study was to determine the prevalence and concentration of 5 specific isothiazolinones (methylisothiazolinone [MI], methylchloroisothiazolinone [MCI], benzisothiazolinone [BIT], butyl BIT, and octylisothiazolinone) in US adhesives.Methods: Thirty-eight consumer adhesives were analyzed using ultrahigh-performance liquid chromatographic-mass spectrometry. Fisher exact tests were used to test for isothiazolinone content and: 1) glue format (2) application purpose and 3) extraction method.Results: Nineteen adhesives (50%) had at least 1 isothiazolinone, and 15 contained 2 isothiazolinones. Frequencies and concentrations were as follows:MI (44.7%; 4-133 ppm), MCI (31.6%; 7-27 ppm), BIT (15.8%; 10-86 ppm), and octylisothiazolinone (2.6%; 1 ppm). Butyl BIT was not detected in any of the adhesives. Format (stick vs liquid) was not statistically associated with isothiazolinone presence. At least half of adhesives in the following application purposes had at least 1 isothiazolinone: shoe, craft, fabric, and school. All-purpose glues had a statistically significant lower concentration of MI and MCI, whereas craft glues were associated with higher concentrations of MI and MCI. Compared with other glues, fabric adhesives were associated with a higher risk of containing BIT.

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“…Contact allergy to chloroacetamide was first described in 1971 (1), and has been reported at extremely low concentrations (8). It has caused allergic contact dermatitis in cosmetics, such as baby lotion (1), bath oils, shampoo (4), hand lotion (2), facial cleanser (3), moist toilet paper and massage cream (5), cutting oils (4, 9), glues (6, 7), nylon spin finish (10), and wall paints (11, 12). 10% of house painters with active hand eczema reacted to chloroacetamide on patch testing (11).…”

Section: Discussionmentioning

confidence: 99%

“…Chloroacetamide, a colourless and odourless powder, is an industrial preservative also used in cosmetics (1–5), glue (5–7), leather, shoe polish and industrial oils (4).…”

mentioning

confidence: 99%

Airborne contact dermatitis due to chloroacetamide in wall paint

2001

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Occupational allergic contact dermatitis from a glue, containing isothiazolinones and N‐methylol‐chloroacetamide, in a carpenter

Cited by 19 publications

References 12 publications

Allergic contact dermatitis to slime: The epidemic of isothiazolinone allergy encompasses school glue

Allergic contact dermatitis to slime: The epidemic of isothiazolinone allergy encompasses school glue

Isothiazolinone Content of US Consumer Adhesives: Ultrahigh-Performance Liquid Chromatographic Mass Spectrometry Analysis

Airborne contact dermatitis due to chloroacetamide in wall paint

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