Occupational and Environmental Health in the Aluminum Industry

Wesdock, James C.; Arnold, Ian

doi:10.1097/jom.0000000000000071

Cited by 44 publications

(22 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Local subcutaneous or intramuscular inflammation may also be observed after injection of vaccines containing aluminum adjuvants (Riihimäki and Aitio, 2012;Wesdock and Arnold, 2014). The…”

Section: Discussionmentioning

confidence: 99%

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction

et al. 2017

View full text Add to dashboard Cite

Mineralogical analyses of clinical samples have been proved useful to identify causal relationship between exposure to airborne particles and pulmonary diseases. The most striking example is asbestosis where the assessment of asbestos bodies in patient lung samples has allowed defining values specific of pathologies. However this type of analyses only considers the micro-sized fraction of the particles, neglecting the specific impact of nano-sized particles which have been otherwise shown to be reactive and able to induce biological effects.Similarly, in nanotoxicology, the mineralogical analysis of pulmonary fluids could be used as an indicator of exposure to inhaled nanoparticles and could help investigations on the relationship between exposure to these nanoparticles and lung diseases. We designed this study first to demonstrate the technical feasibility of this approach, then to get a clear picture of the metals present, and in what form, in patient lungs and finally to determine if indeed it is worth investigating separately the micro, sub-micro and nano fractions. Broncho-alveolar lavages were recovered from 100 patients suffering from interstitial lung diseases. A protocol was specifically developed to isolate 3 fractions containing respectively microparticles, submicroparticles and nanoparticles with ions. The metal content in each fraction was qualitatively and quantitatively characterized. Results showed significant differences between the 3 fractions in terms of metal load confirming that the separate analysis of the fractions is relevant. It also means that the assessment of the micro-sized fraction alone, as commonly done in clinical practice, only gives a partial view of the mineralogical analysis.

show abstract

“…Local subcutaneous or intramuscular inflammation may also be observed after injection of vaccines containing aluminum adjuvants (Riihimäki and Aitio, 2012;Wesdock and Arnold, 2014). The…”

Section: Discussionmentioning

confidence: 99%

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Asthma may be caused by Al exposure (Burge et al, 2000), though the asthma among Al workers may be due to other chemical factors like gases and smoke (Taiwo et al, 2006). Reactive airways dysfunction syndrome was rarely reported among Al smelter workers (Wesdock and Arnold, 2014). Acute-duration oral exposure to Al phosphide has been reported to cause pulmonary edema in persons following accidental or volitional ingestion (Chopra et al, 1986;Khosla et al, 1988).…”

Section: Pulmonary Effectmentioning

confidence: 99%

Aluminium toxicosis: a review of toxic actions and effects

Igbokwe

Igwenagu

Igbokwe

2019

Interdisciplinary Toxicology

274

149

View full text Add to dashboard Cite

Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn’s disease, inflammatory bowel diseases, anemia, Alzheimer’s disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus. The review provides a broad overview of Al toxicosis as a background for sustained investigations of the toxicology of Al compounds of public health importance.

show abstract

“…Exposure is more common among people working in Al industries. [ 3 ] The extensive use of Al cookware leads to ingestion of small quantities of Al every day. Food samples tested were found to contain Al levels in the range of 0.01 to 1.06 mg/g in 27 out of the total 90 samples tested.…”

Section: Introductionmentioning

confidence: 99%

Erratum: Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats

Eerike

et al. 2017

Indian J Pharmacol

View full text Add to dashboard Cite

Occupational and Environmental Health in the Aluminum Industry

Cited by 44 publications

References 21 publications

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction

Aluminium toxicosis: a review of toxic actions and effects

Erratum: Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats

Contact Info

Product

Resources

About