Occupational and environmental risk factors for brain cancer: a pilot case-control study in France

Spinelli, Valérie; Chinot, Olivier; Cabaniols, Cécilia; Giorgi, Roch; Alla, P.; Lehucher-Michel, Marie-Pascale

doi:10.1016/j.lpm.2009.06.020

Cited by 15 publications

(10 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The following chemicals are considered as potentially dangerous: pesticides, polycyclic aromatic compounds and solvents. Electromagnetic fields and certain metals are also considered to be involved in glioma development [ 28 ]. It is believed that the use of a mobile phone does not increase the risk of developing glioblastoma, but the effect of long-term use of mobile phones is still undetermined.…”

Section: Etiologymentioning

confidence: 99%

Review Glioblastoma multiforme – an overview

Urbańska¹,

Sokołowska²,

Szmidt³

et al. 2014

228

217

View full text Add to dashboard Cite

Glioblastoma multiforme is a central nervous system tumor of grade IV histological malignancy according to the WHO classification. Over 90% of diagnosed glioblastomas multiforme cases are primary gliomas, arising from normal glial cells through multistep oncogenesis. The remaining 10% are secondary gliomas originating from tumors of lower grade. These tumors expand distinctly more slowly. Although genetic alterations and deregulations of molecular pathways leading to both primary and secondary glioblastomas formation differ, morphologically they do not reveal any significant differences. Glioblastoma is a neoplasm that occurs spontaneously, although familial gliomas have also been noted. Caucasians, especially those living in industrial areas, have a higher incidence of glioblastoma. Cases of glioblastoma in infants and children are also reported. The participation of sex hormones and viruses in its oncogenesis was also suggested. Progression of glioblastoma multiforme is associated with deregulation of checkpoint G1/S of a cell cycle and occurrence of multiple genetic abnormalities of tumor cells. Metastases of glioblastoma multiforme are rarely described. Treatment of glioblastoma multiforme includes tumor resection, as well as radiotherapy and chemotherapy. Drugs inhibiting integrin signaling pathways and immunotherapy are also employed. Treatment modalities and prognosis depend on the tumor localization, degree of its malignancy, genetic profile, proliferation activity, patient's age and the Karnofsky performance scale score. Although the biology of glioblastoma multiforme has recently been widely investigated, the studies summarizing the knowledge of its development and treatment are still not sufficient in terms of comprehensive brain tumor analysis.

show abstract

Section: Etiologymentioning

confidence: 99%

Review Glioblastoma multiforme – an overview

Urbańska¹,

Sokołowska²,

Szmidt³

et al. 2014

228

217

View full text Add to dashboard Cite

show abstract

“…Multiple studies have shown that risk factors for brain cancers could be related to occupational and environmental factors. Some of those risk factors are electromagnetic radiation from wireless devices, synthetic rubber manufacturing, petrochemical industries, farming, air pollutants, dietary, tobacco, and residues near landfills [10][11][12]. With its multiple waste landfills, many consider Texas to be the world capital for the oil and natural gas industry.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Primary Central Nervous System Tumors Among the Hispanic Population in Texas 1995-2013

Ambe

Nizamutdinov

Huang

et al. 2020

Cureus

View full text Add to dashboard Cite

Introduction: Primary central nervous system (CNS) tumors constitute a group of rare and heterogeneous tumors. A rising incidence rate in the United States has been linked to modern changes in early diagnosis and reporting. This study aims to examine temporal incidence trends, geographic variation, and the average annual age-adjusted rates among Hispanic populations in Texas from 1995 to 2013. Methods: SEER*STAT (Surveillance Research Program, National Cancer Institute (seer.cancer.gov/seerstat) version 8.3.2) and Joinpoint Regression 4.4.0.0 (Statistical Methodology and Applications Branch, Surveillance Research Program, National Cancer Institute) software were used to analyze incidence of primary brain and CNS tumors among Texas residents. Data were obtained from the Texas Cancer Registry of the Texas Department of State Health Services. Results: From the 30,122 cases of primary CNS tumors diagnosed throughout the state of Texas from 2008 to 2012, the overall average annual age-adjusted incidence rate for Hispanics and non-Hispanics combined was 25.35 per 100,000 persons. Among Hispanics, West Texas had the highest incidence trends and the highest average age-adjusted incidence rate of 27.17, followed by North Texas at 26.01 and the Panhandle at 23.63. East Texas had the lowest incidence rate of 16.23. The incidence trend among Hispanics has decreased consistently at a rate of 0.83 % from 1995 to 2013. Conclusions: The incidence of tumors was more pronounced in the Hispanic population in northern Texas compared with southern Texas. The presence of oil and gas production industries with farming and construction could play a role in the observed incidence of disease. Further studies with a focus on occupational health among Hispanics in Texas will be needed to elucidate the cause of such distribution.

show abstract

“…112 The increased incidences of malignant brain tumors reported in several studies are attributed to environmental factors and occupational exposure. 20 Ionizing radiation is an established risk factor for brain cancer, as reported by Sadetzki et al (2005). 106 X-radiation and gamma radiation have been shown to cause a broad spectrum of genetic damage, including gene mutations, minisatellite mutations, micronucleus formation, chromosomal aberrations, ploidy changes, DNA strand breaks and chromosomal instability.…”

Section: Discussionmentioning

confidence: 99%

“…There is also a concern that people involved in certain occupations, such as electrical, petrochemical, agriculture, nuclear, airline and hospital radiation department, may be at an elevated risk of brain cancer. [15][16][17][18][19][20] Several environmental and dietary neurocarcinogens have been reported to be associated with glioma and meningioma risks, but research is still underway to confirm such factors. Besides genetic disorders, head injury and trauma have been identified as risk factors.…”

Section: Introductionmentioning

confidence: 99%

Mutations of the human interferon alpha-2b gene in brain tumor patients exposed to different environmental conditions

et al. 2015

View full text Add to dashboard Cite

This study was aimed at finding out mutations of an anticancerous, antiviral and immunomodulatory gene (human interferon alpha-2b) in low- and high-grade brain tumor patients and correlate from hematological profiles. A molecular analysis was performed in which DNAs were extracted from brain biopsy samples of brain tumor patients. The gene was amplified through the PCR technique, and genetic data from sequencing were analyzed by bioinformatics to determine how mutations will lead to changes in human interferon alpha 2b protein in patients. A total of 38% gene mutations were identified among brain tumor patients. The highest percentage of (36%) frameshift mutations was identified. Hematological analysis shows modulations in the 'lymphocytes' parameter in a majority (64%) of the brain tumor patients. Environmental factors have been reported as risks of brain cancer. Patients were found to be under environmental stress from contaminated drinking water and from local gamma radiations. Brain tumor patients were found to have various mutations in an immunomodulating human interferon alpha-2b gene. These patients had immunosuppression that was further affirmed from their hematological profiles. This analysis may be helpful to develop certain biomarkers that may be used to develop novel immunotherapeutical drugs, which enhance a better immune response.

show abstract

Occupational and environmental risk factors for brain cancer: a pilot case-control study in France

Cited by 15 publications

References 39 publications

Review Glioblastoma multiforme – an overview

Review Glioblastoma multiforme – an overview

Incidence of Primary Central Nervous System Tumors Among the Hispanic Population in Texas 1995-2013

Mutations of the human interferon alpha-2b gene in brain tumor patients exposed to different environmental conditions

Contact Info

Product

Resources

About